Search Results - "Mazor, Yariv"

Regulation of antibody-mediated complement-dependent cytotoxicity by modulating the intrinsic affinity and binding valency of IgG for target antigen by Wang, Bo, Yang, Chunning, Jin, Xiaofang, Du, Qun, Wu, Herren, Dall'Acqua, William, Mazor, Yariv

“…Complement-dependent cytotoxicity (CDC) is a potent effector mechanism, engaging both innate and adaptive immunity. Although strategies to improve the CDC…”
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Improving target cell specificity using a novel monovalent bispecific IgG design by Mazor, Yariv, Oganesyan, Vaheh, Yang, Chunning, Hansen, Anna, Wang, Jihong, Liu, Hongji, Sachsenmeier, Kris, Carlson, Marcia, Gadre, Dhanesh V, Borrok, Martin Jack, Yu, Xiang-Qing, Dall'Acqua, William, Wu, Herren, Chowdhury, Partha Sarathi

“…Monovalent bispecific IgGs cater to a distinct set of mechanisms of action but are difficult to engineer and manufacture because of complexities associated…”
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Conformation-selective rather than avidity-based binding to tumor associated antigen derived peptide-MHC enables targeting of WT1-pMHC low expressing cancer cells by anti-WT1-pMHC/CD3 T cell engagers by Walseng, Even, Wang, Bo, Yang, Chunning, Patel, Pooja, Zhao, Chihao, Zhang, Hanzhi, Zhao, Peng, Mazor, Yariv

“…T cell engagers, a category of T cell-retargeting immunotherapy, are rapidly transforming clinical cancer care. However, the lack of tumor-specific targets…”
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Isolation of engineered, full-length antibodies from libraries expressed in Escherichia coli by Georgiou, George, Mazor, Yariv, Blarcom, Thomas Van, Mabry, Robert, Iverson, Brent L

“…We describe facile isolation of full-length IgG antibodies from combinatorial libraries expressed in E. coli. Full-length heavy and light chains are secreted…”
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Enhancement of Immune Effector Functions by Modulating IgG's Intrinsic Affinity for Target Antigen by Mazor, Yariv, Yang, Chunning, Borrok, M Jack, Ayriss, Joanne, Aherne, Karen, Wu, Herren, Dall'Acqua, William F

“…Antibody-mediated immune effector functions play an essential role in the anti-tumor efficacy of many therapeutic mAbs. While much of the effort to improve…”
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IL-2-armored peptide-major histocompatibility class I bispecific antibodies redirect antiviral effector memory CD8+ T cells to induce potent anti-cancer cytotoxic activity with limited cytokine release by Schardt, John S, Walseng, Even, Le, Kim, Yang, Chunning, Shah, Pooja, Fu, Ying, Alam, Kausar, Kelton, Cathryn R, Gu, Yu, Huang, Fengying, Lin, Jia, Liu, Wenhai, Dippel, Andrew, Zhang, Hanzhi, Mulgrew, Kathy, Pryts, Stacy, Chennupati, Vijaykumar, Chen, Hung-Chang, Denham, Jessica, Chen, Xiaoru, Pradhan, Pallab, Wu, Yuling, Hardman, Colin, Zhao, Chihao, Kierny, Michael, Song, Yang, Dovedi, Simon J, Cemerski, Saso, Mazor, Yariv

“…T cell engagers (TCEs) are becoming an integral class of biological therapeutic owing to their highly potent ability to eradicate cancer cells. Nevertheless,…”
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Selection of full-length IgGs by tandem display on filamentous phage particles and Escherichia coli fluorescence-activated cell sorting screening by Mazor, Yariv, Van Blarcom, Thomas, Carroll, Sean, Georgiou, George

“…Phage display of antibody libraries is a powerful tool for antibody discovery and evolution. Recombinant antibodies have been displayed on phage particles as…”
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Robust production of monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the CH1-Cλ interface by Bagert, John D, Oganesyan, Vaheh, Chiang, Chi-I, Iannotti, Mike, Lin, Jia, Yang, Chunning, Payne, Sterling, McMahon, Will, Edwards, Samuel, Dippel, Andrew, Hutchinson, Mark, Huang, Fengying, Aleti, Vineela, Niu, Chendi, Qian, Chen, Denham, Jessica, Ferreira, Sofia, Pradhan, Pallab, Penney, Mark, Wang, Chunlei, Liu, Wenhai, Walseng, Even, Mazor, Yariv

“…Bispecific antibodies represent an increasingly large fraction of biologics in therapeutic development due to their expanded scope in functional capabilities…”
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Identification and Characterization of a Novel Molecular-recognition and Self-assembly Domain within the Islet Amyloid Polypeptide by Mazor, Yariv, Gilead, Sharon, Benhar, Itai, Gazit, Ehud

“…The islet amyloid polypeptide (hIAPP) is a 37 amino acid residue polypeptide that was found to accumulate as amyloid fibrils in the pancreas of individuals…”
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A Novel Dual Expression Platform for High Throughput Functional Screening of Phage Libraries in Product like Format by Xiao, Xiaodong, Chen, Yan, Mugabe, Sheila, Gao, Changshou, Tkaczyk, Christine, Mazor, Yariv, Pavlik, Peter, Wu, Herren, Dall'Acqua, William, Chowdhury, Partha Sarathi

“…High throughput screenings of single chain Fv (scFv) antibody phage display libraries are currently done as soluble scFvs produced in E.coli. Due to endotoxin…”
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E -clonal antibodies: selection of full-length IgG antibodies using bacterial periplasmic display by Georgiou, George, Mazor, Yariv, Van Blarcom, Thomas, Iverson, Brent L

“…Here we describe a protocol for the selection of full-length IgG antibodies from repertoires displayed on Escherichia coli . In the method described here,…”
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Rapid construction and characterization of synthetic antibody libraries without DNA amplification by Ge, Xin, Mazor, Yariv, Hunicke-Smith, Scott P, Ellington, Andrew D, Georgiou, George

“…We report on a simple method to rapidly generate very large libraries of genes encoding mutant proteins without the use of DNA amplification, and the…”
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chFRP5-ZZ-PE38, a large IgG-toxin immunoconjugate outperforms the corresponding smaller FRP5(Fv)-ETA immunotoxin in eradicating ErbB2-expressing tumor xenografts by Mazor, Yariv, Noy, Roy, Wels, Winfried S, Benhar, Itai

“…Abstract As therapeutics, antibodies can be used “un-armed” or as immunoconjugates to direct cytotoxic moieties to tumor cells. Immunoconjugates are made by…”
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Enhanced tumor-targeting selectivity by modulating bispecific antibody binding affinity and format valence by Mazor, Yariv, Sachsenmeier, Kris F., Yang, Chunning, Hansen, Anna, Filderman, Jessica, Mulgrew, Kathy, Wu, Herren, Dall’Acqua, William F.

“…Bispecific antibodies are considered attractive bio-therapeutic agents owing to their ability to target two distinct disease mediators. Cross-arm avidity…”
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Design and Efficacy of a Monovalent Bispecific PD-1/CTLA4 Antibody That Enhances CTLA4 Blockade on PD-1 + Activated T Cells by Dovedi, Simon J, Elder, Matthew J, Yang, Chunning, Sitnikova, Suzanne I, Irving, Lorraine, Hansen, Anna, Hair, James, Jones, Des C, Hasani, Sumati, Wang, Bo, Im, Seock-Ah, Tran, Ben, Subramaniam, Deepa S, Gainer, Shelby D, Vashisht, Kapil, Lewis, Arthur, Jin, Xiaofang, Kentner, Stacy, Mulgrew, Kathy, Wang, Yaya, Overstreet, Michael G, Dodgson, James, Wu, Yanli, Palazon, Asis, Morrow, Michelle, Rainey, Godfrey J, Browne, Gareth J, Neal, Frances, Murray, Thomas V, Toloczko, Aleksandra D, Dall'Acqua, William, Achour, Ikbel, Freeman, Daniel J, Wilkinson, Robert W, Mazor, Yariv

“…The clinical benefit of PD-1 blockade can be improved by combination with CTLA4 inhibition but is commensurate with significant immune-related adverse events…”
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Preclinical Evaluation of AZD6422, an Armored Chimeric Antigen Receptor T Cell Targeting CLDN18.2 in Gastric, Pancreatic, and Esophageal Cancers by Barrett, Allison M., Britton, Zachary T., Carrasco, Rosa A., Breen, Shannon, Broggi, Maria A.S., Hatke, Amanda L., Clark, Benjamin, Yang, Chunning, Phipps, Sandrina, Ortiz, Lorenzo, Janocha, Brianna, Zanvit, Peter, Giraldo, Nicolas A., Martin, Philip L., Lapointe, Jean-Martin, Harder, Nathalie, Cornish, Georgina H., Attili, Bala N.N.R., Mazor, Yariv, Damschroder, Melissa, Cobbold, Mark, Moody, Gordon, Bosco, Emily E.

“…Abstract Purpose: Claudin 18.2 (CLDN18.2) is a surface membrane protein that is crucial for maintaining tight junctions in gastric mucosal cells and is highly…”
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A single homogeneous assay for simultaneous measurement of bispecific antibody target binding by Christian, Elizabeth A., Hussmann, G. Patrick, Babu, Meghna, Prophet, Meagan, Mazor, Yariv, Chen, Weimin, Grigoriadou, Christina, Lin, Shihua

“…Bispecific antibodies (BsAbs) are engineered to simultaneously bind two different antigens, and offer promising clinical outcomes for various diseases. The…”
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Inhibition of Islet Amyloid Polypeptide Fibril Formation:  A Potential Role for Heteroaromatic Interactions by Porat, Yair, Mazor, Yariv, Efrat, Shimon, Gazit, Ehud

“…The formation of amyloid fibril is associated with major human diseases, including Alzheimer's disease, prion diseases, and type 2 diabetes. Methods for…”
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Insights into the molecular basis of a bispecific antibody's target selectivity by Mazor, Yariv, Hansen, Anna, Yang, Chunning, Chowdhury, Partha S, Wang, Jihong, Stephens, Geoffrey, Wu, Herren, Dall'Acqua, William F

“…Bispecific antibodies constitute a valuable class of therapeutics owing to their ability to bind 2 distinct targets. Dual targeting is thought to enhance…”
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Escherichia coli maltose-binding protein as a molecular chaperone for recombinant intracellular cytoplasmic single-chain antibodies 1 1Edited by R. Huber by Bach, Horacio, Mazor, Yariv, Shaky, Shelly, Shoham-Lev, Atar, Berdichevsky, Yevgeny, Gutnick, David L, Benhar, Itai

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