Search Results - "Mazo, Manuel M."

Quantitative volumetric Raman imaging of three dimensional cell cultures by Kallepitis, Charalambos, Bergholt, Mads S., Mazo, Manuel M., Leonardo, Vincent, Skaalure, Stacey C., Maynard, Stephanie A., Stevens, Molly M.

“…The ability to simultaneously image multiple biomolecules in biologically relevant three-dimensional (3D) cell culture environments would contribute greatly to…”
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Surface Dynamics and Ligand–Core Interactions of Quantum Sized Photoluminescent Gold Nanoclusters by Lin, Yiyang, Charchar, Patrick, Christofferson, Andrew J, Thomas, Michael R, Todorova, Nevena, Mazo, Manuel M, Chen, Qu, Doutch, James, Richardson, Robert, Yarovsky, Irene, Stevens, Molly M

“…Quantum-sized metallic clusters protected by biological ligands represent a new class of luminescent materials; yet the understanding of structural information…”
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Engineering and Assessing Cardiac Tissue Complexity by Tadevosyan, Karine, Iglesias-García, Olalla, Mazo, Manuel M, Prósper, Felipe, Raya, Angel

“…Cardiac tissue engineering is very much in a current focus of regenerative medicine research as it represents a promising strategy for cardiac disease…”
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Biomaterials-Based Antioxidant Strategies for the Treatment of Oxidative Stress Diseases by Perez-Araluce, Maria, Jüngst, Tomasz, Sanmartin, Carmen, Prosper, Felipe, Plano, Daniel, Mazo, Manuel M

“…Oxidative stress is characterized by an increase in reactive oxygen species or a decrease in antioxidants in the body. This imbalance leads to detrimental…”
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Cells, Materials, and Fabrication Processes for Cardiac Tissue Engineering by Montero, Pilar, Flandes-Iparraguirre, María, Musquiz, Saioa, Pérez Araluce, María, Plano, Daniel, Sanmartín, Carmen, Orive, Gorka, Gavira, Juan José, Prosper, Felipe, Mazo, Manuel M.

“…Cardiovascular disease is the number one killer worldwide, with myocardial infarction (MI) responsible for approximately 1 in 6 deaths. The lack of endogenous…”
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Preventing tissue fibrosis by local biomaterials interfacing of specific cryptic extracellular matrix information by Horejs, Christine-Maria, St-Pierre, Jean-Philippe, Ojala, Juha R. M., Steele, Joseph A. M., da Silva, Patricia Barros, Rynne-Vidal, Angela, Maynard, Stephanie A., Hansel, Catherine S., Rodríguez-Fernández, Clara, Mazo, Manuel M., You, Amanda Y. F., Wang, Alex J., von Erlach, Thomas, Tryggvason, Karl, López-Cabrera, Manuel, Stevens, Molly M.

“…Matrix metalloproteinases (MMPs) contribute to the breakdown of tissue structures such as the basement membrane, promoting tissue fibrosis. Here we developed…”
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Generation of an induced pluripotent stem cell line (ESi107-A) from a transthyretin amyloid cardiomyopathy (ATTR-CM) patient carrying a p.Ser43Asn mutation in the TTR gene by Montero-Calle, Pilar, Flandes-Iparraguirre, María, Kuebler, Bernd, Arán, Begoña, Larequi, Eduardo, Anaut, Ilazki, Coppiello, Giulia, Aranguren, Xabier L., Veiga, Anna, Elorz, Maria Teresa Basurte, de Yébenes, Manuel García, Gavira, Juan J., Prósper, Felipe, Iglesias-García, Olalla, Vega, Manuel M. Mazo

“…Transthyretin (TTR) amyloid cardiomyopathy (ATTR-CM) is a life-threatening disease caused by the abnormal production of misfolded TTR protein by liver cells,…”
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Pristine Photopolymerizable Gelatin Hydrogels: A Low-Cost and Easily Modifiable Platform for Biomedical Applications by Pérez-Araluce, Maria, Cianciosi, Alessandro, Iglesias-García, Olalla, Jüngst, Tomasz, Sanmartín, Carmen, Navarro-Blasco, Íñigo, Prósper, Felipe, Plano, Daniel, Mazo, Manuel M

“…The study addresses the challenge of temperature sensitivity in pristine gelatin hydrogels, widely used in biomedical applications due to their…”
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Current approaches for the recreation of cardiac ischaemic environment in vitro by Paz-Artigas, Laura, Montero-Calle, Pilar, Iglesias-García, Olalla, Mazo, Manuel M., Ochoa, Ignacio, Ciriza, Jesús

“…[Display omitted] Myocardial ischaemia is one of the leading dead causes worldwide. Although animal experiments have historically provided a wealth of…”
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Activatable cell-biomaterial interfacing with photo-caged peptides by Lin, Yiyang, Mazo, Manuel M, Skaalure, Stacey C, Thomas, Michael R, Schultz, Simon R, Stevens, Molly M

“…Spatio-temporally tailoring cell-material interactions is essential for developing smart delivery systems and intelligent biointerfaces. Here we report new…”
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Exploring the inner environment of protein hydrogels with fluorescence spectroscopy towards understanding their drug delivery capabilities by Nandi, Ramesh, Yucknovsky, Anna, Mazo, Manuel M, Amdursky, Nadav

“…Hydrogels are common platforms for drug delivery applications. Amongst the different loading and release methodologies, physisorption loading and passive…”
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Experimentally-guided in silico design of engineered heart tissues to improve cardiac electrical function after myocardial infarction by Rosales, Ricardo M., Mountris, Konstantinos A., Oliván-Viguera, Aida, Pérez-Zabalza, María, Cedillo-Servin, Gerardo, Iglesias-García, Olalla, Hrynevich, Andrei, Castilho, Miguel, Malda, Jos, Prósper, Felipe, Doblaré, Manuel, Mazo, Manuel M., Pueyo, Esther

“…Engineered heart tissues (EHTs) built from human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) showed promising results for cardiac function…”
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Multiplexing physical stimulation on single human induced pluripotent stem cell-derived cardiomyocytes for phenotype modulation by Kit-Anan, Worrapong, Mazo, Manuel M, Wang, Brian X, Leonardo, Vincent, Pence, Isaac J, Gopal, Sahana, Gelmi, Amy, Nagelkerke, Anika, Becce, Michele, Chiappini, Ciro, Harding, Sian E, Terracciano, Cesare M, Stevens, Molly M

“…Traditional in vitro bioengineering approaches whereby only individual biophysical cues are manipulated at any one time are highly inefficient, falling short…”
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Generation of Self-Induced Myocardial Ischemia in Large-Sized Cardiac Spheroids without Alteration of Environmental Conditions Recreates Fibrotic Remodeling and Tissue Stiffening Revealed by Constriction Assays by Paz-Artigas, Laura, González-Lana, Sandra, Polo, Nicolás, Vicente, Pedro, Montero-Calle, Pilar, Martínez, Miguel A., Rábago, Gregorio, Serra, Margarida, Prósper, Felipe, Mazo, Manuel M., González, Arantxa, Ochoa, Ignacio, Ciriza, Jesús

“…A combination of human-induced pluripotent stem cells (hiPSCs) and 3D microtissue culture techniques allows the generation of models that recapitulate the…”
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A Fibrosis Biomarker Early Predicts Cardiotoxicity Due to Anthracycline-Based Breast Cancer Chemotherapy by de la Fuente, Ana, Santisteban, Marta, Lupón, Josep, Aramendía, José Manuel, Díaz, Agnes, Santaballa, Ana, Hernándiz, Amparo, Sepúlveda, Pilar, Cediel, Germán, López, Begoña, Picazo, José María López, Mazo, Manuel M, Rábago, Gregorio, Gavira, Juan José, García-Bolao, Ignacio, Díez, Javier, González, Arantxa, Bayés-Genís, Antoni, Ravassa, Susana

“…Anthracycline-based cancer chemotherapy (ACC) causes myocardial fibrosis, a lesion contributing to left ventricular dysfunction (LVD). We investigated whether…”
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Engineering a Humanised Niche to Support Human Haematopoiesis in Mice: Novel Opportunities in Modelling Cancer by Sanchez-Herrero, Alvaro, Calvo, Isabel A., Flandes-Iparraguirre, Maria, Landgraf, Marietta, Lahr, Christoph A., Shafiee, Abbas, Granero-Molto, Froilán, Saez, Borja, Mazo, Manuel M., Paiva, Bruno, de Juan Pardo, Elena, Nicol, Andrew, Prosper, Felipe, Bray, Laura J., McGovern, Jacqui A.

“…Despite the bone marrow microenvironment being widely recognised as a key player in cancer research, the current animal models that represent a human…”
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Priorities in Cardio-Oncology Basic and Translational Science: GCOS 2023 Symposium Proceedings: JACC: CardioOncology State-of-the-Art Review by Salloum, Fadi N, Tocchetti, Carlo G, Ameri, Pietro, Ardehali, Hossein, Asnani, Aarti, de Boer, Rudolf A, Burridge, Paul, Cabrera, José-Ángel, de Castro, Javier, Córdoba, Raúl, Costa, Ambra, Dent, Susan, Engelbertsen, Daniel, Fernández-Velasco, María, Fradley, Mike, Fuster, José J, Galán-Arriola, Carlos, García-Lunar, Inés, Ghigo, Alessandra, González-Neira, Anna, Hirsch, Emilio, Ibáñez, Borja, Kitsis, Richard N, Konety, Suma, Lyon, Alexander R, Martin, Pilar, Mauro, Adolfo G, Mazo Vega, Manuel M, Meijers, Wouter C, Neilan, Tomas G, Rassaf, Tienush, Ricke-Hoch, Melanie, Sepulveda, Pilar, Thavendiranathan, Paaladinesh, van der Meer, Peter, Fuster, Valentin, Ky, Bonnie, López-Fernández, Teresa

“…Despite improvements in cancer survival, cancer therapy-related cardiovascular toxicity has risen to become a prominent clinical challenge. This has led to the…”
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In Silico Assessment of Arrhythmic Risk in Infarcted Ventricles Engrafted with Engineered Heart Tissues by Rosales, Ricardo M, Mountris, Konstantinos A, Doblare, Manuel, Mazo, Manuel M, Pueyo, Esther

“…Engineered heart tissues (EHTs) from human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) represent novel alternatives to repair damaged…”
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Ventricular Conduction System Modeling for Electrophysiological Simulation of the Porcine Heart by Rosales, Ricardo M, Mountris, Konstantinos A, Doblare, Manuel, Mazo, Manuel M, Pueyo, Esther

“…Depolarization sequences triggering mechanical contraction of the heart are largely determined by the cardiac conduction system (CS) . Many biophysical models…”
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In Silico Electrophysiological Evaluation of Scaffold Geometries for Cardiac Tissue Engineering by Rosales, Ricardo M, Mountris, Konstantinos A, Doblare, Manuel, Mazo, Manuel M, Pueyo, Esther

“…Human induced pluripotent stem cell-derived car-diomyocytes (hiPSC-CMs) cultured on bio-printed scaffolds have shown promising results for cardiac function…”
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