Search Results - "Mazloom, Amin"

ChEA: transcription factor regulation inferred from integrating genome-wide ChIP-X experiments by Lachmann, Alexander, Xu, Huilei, Krishnan, Jayanth, Berger, Seth I., Mazloom, Amin R., Ma'ayan, Avi

“…Motivation: Experiments such as ChIP-chip, ChIP-seq, ChIP-PET and DamID (the four methods referred herein as ChIP-X) are used to profile the binding of…”
Get full text

Clinical validation of a noninvasive prenatal test for genomewide detection of fetal copy number variants by Lefkowitz, Roy B., PhD, Tynan, John A., PhD, Liu, Tong, PhD, Wu, Yijin, PhD, Mazloom, Amin R., PhD, Almasri, Eyad, MS, Hogg, Grant, MS, Angkachatchai, Vach, PhD, Zhao, Chen, PhD, Grosu, Daniel S., MD, McLennan, Graham, MS, Ehrich, Mathias, MD

“…Background Current cell-free DNA assessment of fetal chromosomes does not analyze and report on all chromosomes. Hence, a significant proportion of fetal…”
Get full text

Sox2 in the Dermal Papilla Niche Controls Hair Growth by Fine-Tuning BMP Signaling in Differentiating Hair Shaft Progenitors by Clavel, Carlos, Grisanti, Laura, Zemla, Roland, Rezza, Amelie, Barros, Rita, Sennett, Rachel, Mazloom, Amin Reza, Chung, Chi-Yeh, Cai, Xiaoqiang, Cai, Chen-Leng, Pevny, Larysa, Nicolis, Silvia, Ma'ayan, Avi, Rendl, Michael

“…How dermal papilla (DP) niche cells regulate hair follicle progenitors to control hair growth remains unclear. Using Tbx18Cre to target embryonic DP…”
Get full text

Non-invasive prenatal chromosomal aneuploidy testing--clinical experience: 100,000 clinical samples by McCullough, Ron M, Almasri, Eyad A, Guan, Xiaojun, Geis, Jennifer A, Hicks, Susan C, Mazloom, Amin R, Deciu, Cosmin, Oeth, Paul, Bombard, Allan T, Paxton, Bill, Dharajiya, Nilesh, Saldivar, Juan-Sebastian

“…As the first laboratory to offer massively parallel sequencing-based noninvasive prenatal testing (NIPT) for fetal aneuploidies, Sequenom Laboratories has been…”
Get full text

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche by MacArthur, Ben D, Scadden, David T, Enikolopov, Grigori N, Méndez-Ferrer, Simón, Ma'ayan, Avi, Frenette, Paul S, Lira, Sergio A, Michurina, Tatyana V, Ferraro, Francesca, Mazloom, Amin R

“…The cellular constituents forming the haematopoietic stem cell (HSC) niche in the bone marrow are unclear, with studies implicating osteoblasts, endothelial…”
Get full text

Determination of fetal DNA fraction from the plasma of pregnant women using sequence read counts by Kim, Sung K., Hannum, Gregory, Geis, Jennifer, Tynan, John, Hogg, Grant, Zhao, Chen, Jensen, Taylor J., Mazloom, Amin R., Oeth, Paul, Ehrich, Mathias, van den Boom, Dirk, Deciu, Cosmin

“…Objective This study introduces a novel method, referred to as SeqFF, for estimating the fetal DNA fraction in the plasma of pregnant women and to infer the…”
Get full text

High-throughput massively parallel sequencing for fetal aneuploidy detection from maternal plasma by Jensen, Taylor J, Zwiefelhofer, Tricia, Tim, Roger C, Džakula, Željko, Kim, Sung K, Mazloom, Amin R, Zhu, Zhanyang, Tynan, John, Lu, Tim, McLennan, Graham, Palomaki, Glenn E, Canick, Jacob A, Oeth, Paul, Deciu, Cosmin, van den Boom, Dirk, Ehrich, Mathias

“…Circulating cell-free (ccf) fetal DNA comprises 3-20% of all the cell-free DNA present in maternal plasma. Numerous research and clinical studies have…”
Get full text

Genome-wide sequencing of cell-free DNA identifies copy number alterations that can be used for monitoring response to immunotherapy in cancer patients by Jensen, Taylor J, Goodman, Aaron M, Kato, Shumei, Ellison, Christopher K, Daniels, Gregory A, Kim, Lisa, Nakashe, Prachi, McCarthy, Erin, Mazloom, Amin R, McLennan, Graham, Grosu, Daniel S, Ehrich, Mathias, Kurzrock, Razelle

“…Inhibitors of the PD-1/PD-L1/CTLA4 immune checkpoint pathway have revolutionized cancer treatment. Indeed, some patients with advanced, refractory malignancies…”
Get full text

Noninvasive prenatal detection of sex chromosomal aneuploidies by sequencing circulating cell-free DNA from maternal plasma by Mazloom, Amin R., Džakula, Željko, Oeth, Paul, Wang, Huiquan, Jensen, Taylor, Tynan, John, McCullough, Ron, Saldivar, Juan-Sebastian, Ehrich, Mathias, van den Boom, Dirk, Bombard, Allan T., Maeder, Margo, McLennan, Graham, Meschino, Wendy, Palomaki, Glenn E., Canick, Jacob A., Deciu, Cosmin

“…ABSTRACT Objective Whole‐genome sequencing of circulating cell free (ccf) DNA from maternal plasma has enabled noninvasive prenatal testing for common…”
Get full text

Analytical validation of a novel panel of biomarkers for a test for preeclampsia by Hendershot, Jenna M., Abbasi, Mohammad, Fortier, Laura, Benn, Maleah, Giacobone, Camille, Del Mastro, Richard, Bahrami-Samani, Emad, Mazloom, Amin R., Oberoi, Pankaj

“…Preeclampsia is a serious condition responsible for much pregnancy-related morbidity and mortality. Diagnosis of preeclampsia is difficult due to the…”
Get full text

A systems approach identifies HIPK2 as a key regulator of kidney fibrosis by Jin, Yuanmeng, Ratnam, Krishna, Chuang, Peter Y, Fan, Ying, Zhong, Yifei, Dai, Yan, Mazloom, Amin R, Chen, Edward Y, D'Agati, Vivette, Xiong, Huabao, Ross, Michael J, Chen, Nan, Ma'ayan, Avi, He, John Cijiang

“…HIV infection is often associated with severe nephropathy, including renal fibrosis. John He and his colleagues have used a systems biology approach in a mouse…”
Get full text

Genome-wide Sequencing of Cell-free DNA Enables Detection of Copy-number Alterations in Patients with Cancer Where Tissue Biopsy is Not Feasible by Jensen, Taylor J, Goodman, Aaron M, Ellison, Christopher K, Holden, Kimberly A, Kato, Shumei, Kim, Lisa, Daniels, Gregory A, Fitzgerald, Kerry, McCarthy, Erin, Nakashe, Prachi, Mazloom, Amin R, Almasri, Eyad, McLennan, Graham, Grosu, Daniel S, Eisenberg, Marcia, Kurzrock, Razelle

“…When tissue biopsy is not medically prudent or tissue is insufficient for molecular testing, alternative methods are needed. Because cell-free DNA (cfDNA) has…”
Get full text

Publisher Correction: A systems approach identifies HIPK2 as a key regulator of kidney fibrosis by Jin, Yuanmeng, Ratnam, Krishna, Chuang, Peter Y., Fan, Ying, Zhong, Yifei, Dai, Yan, Mazloom, Amin R., Chen, Edward Y., D’Agati, Vivette, Xiong, Huabao, Ross, Michael J., Chen, Nan, Ma’ayan, Avi, He, John Cijiang

Get full text

ELK1 Transcription Factor Linked to Dysregulated Striatal Mu Opioid Receptor Signaling Network and OPRM1 Polymorphism in Human Heroin Abusers by Sillivan, Stephanie E, Whittard, John D, Jacobs, Michelle M, Ren, Yanhua, Mazloom, Amin R, Caputi, Francesca F, Horvath, Monika, Keller, Eva, Ma’ayan, Avi, Pan, Ying-Xian, Chiang, Lillian W, Hurd, Yasmin L

“…Background Abuse of heroin and prescription opiate medications has grown to disturbing levels. Opioids mediate their effects through mu opioid receptors (MOR),…”
Get full text

Activation of alternate prosurvival pathways accounts for acquired sunitinib resistance in U87MG glioma xenografts by Zhou, Qingyu, Lv, Hua, Mazloom, Amin R, Xu, Huilei, Ma'ayan, Avi, Gallo, James M

“…Acquired drug resistance represents a major obstacle to using sunitinib for the treatment of solid tumors. Here, we examined the cellular and molecular…”
Get more information

Esrrb Regulates Specific Feed-Forward Loops to Transit From Pluripotency Into Early Stages of Differentiation by Mazloom, Amin R, Xu, Huilei, Reig-Palou, Jaume, Vasileva, Ana, Román, Angel-Carlos, Mulero-Navarro, Sonia, Lemischka, Ihor R, Sevilla, Ana

“…Characterization of pluripotent states, in which cells can both self-renew or differentiate, with the irreversible loss of pluripotency, are important research…”
Get full text

Using Targeted Sequencing of Paralogous Sequences for Noninvasive Detection of Selected Fetal Aneuploidies by Ellison, Christopher K, Sun, Youting, Hogg, Grant, Fox, Jesse, Tao, Helen, McCarthy, Erin, Sagoe, Bright, Azab, Mostafa A, Mazloom, Amin R, Tynan, John, Burcham, Timothy, Kim, Sung K, van den Boom, Dirk, Ehrich, Mathias, Jensen, Taylor J

“…Current methods for noninvasive prenatal testing (NIPT) ascertain fetal aneuploidies using either direct counting measures of DNA fragments from specific…”
Get full text

Recovering protein-protein and domain-domain interactions from aggregation of IP-MS proteomics of coregulator complexes by Mazloom, Amin R, Dannenfelser, Ruth, Clark, Neil R, Grigoryan, Arsen V, Linder, Kathryn M, Cardozo, Timothy J, Bond, Julia C, Boran, Aislyn D W, Iyengar, Ravi, Malovannaya, Anna, Lanz, Rainer B, Ma'ayan, Avi

“…Coregulator proteins (CoRegs) are part of multi-protein complexes that transiently assemble with transcription factors and chromatin modifiers to regulate gene…”
Get full text

An Esrrb and Nanog Cell Fate Regulatory Module Controlled by Feed Forward Loop Interactions by Sevilla, Ana, Papatsenko, Dimitri, Mazloom, Amin R, Xu, Huilei, Vasileva, Ana, Unwin, Richard D, LeRoy, Gary, Chen, Edward Y, Garrett-Bakelman, Francine E, Lee, Dung-Fang, Trinite, Benjamin, Webb, Ryan L, Wang, Zichen, Su, Jie, Gingold, Julian, Melnick, Ari, Garcia, Benjamin A, Whetton, Anthony D, MacArthur, Ben D, Ma'ayan, Avi, Lemischka, Ihor R

“…Cell fate decisions during development are governed by multi-factorial regulatory mechanisms including chromatin remodeling, DNA methylation, binding of…”
Get full text

CoCONet: A collision-free container-based core optical network by Mazloom, Amin R., Ghosh, Preetam, Basu, Kalyan, Das, Sajal K.

“…Electrical-to-optical domain conversions and vice versa (denoted by O/E/O conversions) for each hop in optical core transport networks impose considerable…”
Get full text