Idiosyncratic Drug-Induced Liver Injury in a Healthy Patient following PCSK9-Inhibitor Injection

Idiosyncratic Drug-Induced Liver Injury in a Healthy Patient following PCSK9-Inhibitor Injection

Background. Acute liver injury is a life-threatening condition with disparate aetiology. Swift and adequate interdisciplinary treatment is essential to assure the best possible outcomes in these patients. Investigations to identify the cause of the condition and the implementation of quick and appro...

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Bibliographic Details
Published in:Case reports in hepatology Vol. 2024; pp. 1 - 4
Main Authors: Stüben, B.-O., Hoyer, D. P., Radunz, S., Saner, F., Schmidt, H., Baba, H. A., Treckmann, J. W., Mazilescu, L. I.
Format: Journal Article
Language:English
Published: New York Hindawi 11-01-2024
Hindawi Limited
Subjects:
Biopsy
Case Report
Clinical trials
Drug dosages
Drug therapy
Enzymes
Gallbladder
Granulocytes
Hemodialysis
Hepatitis
Hormones
Liver diseases
Patients
Statins
Ultrasonic imaging
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Summary:Background. Acute liver injury is a life-threatening condition with disparate aetiology. Swift and adequate interdisciplinary treatment is essential to assure the best possible outcomes in these patients. Investigations to identify the cause of the condition and the implementation of quick and appropriate treatment can be lifesaving. Case Presentation. In October 2022, an otherwise healthy 66-year-old male presented at the University Hospital Essen with acute liver injury following an inclisiran injection for hypercholesterinaemia. Four weeks following admission, the patient fully recovered after initially receiving short-term cortisol therapy and open albumin (OPAL) dialysis, and the indices of liver, kidney, and coagulation function were normal at discharge. Conclusion. This is to our knowledge the first reported acute liver injury due to an inclisiran injection. Cortisol in combination with OPAL dialysis is an effective method for the treatment of acute liver injury caused by inclisiran injury, and in this case, it led to a near-complete reversal of the acute liver injury at the time of discharge.
Bibliography:Academic Editor: Ned Snyder
ISSN:2090-6587
2090-6595
DOI:10.1155/2024/5556907