Search Results - "Mazer, B. D."

B lymphocytes in inflammatory airway diseases by Drolet, J.-P., Frangie, H., Guay, J., Hajoui, O., Hamid, Q., Mazer, B. D.

“…Summary B lymphocytes are key players in all facets of adaptive immune responses and are responsible for the production of IgE antibodies, initiators of…”
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Intravenous immunoglobulin attenuates airway hyperresponsiveness in a murine model of allergic asthma by Kaufman, G. N., Massoud, A. H., Audusseau, S., Banville-Langelier, A.-A., Wang, Y., Guay, J., Garellek, J. A., Mourad, W., Piccirillo, C. A., McCusker, C., Mazer, B. D.

“…Summary Background Intravenous immunoglobulin (IVIG) has potent anti‐inflammatory and immune‐modulating properties. IVIG has been utilized as a steroid‐sparing…”
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Signal transducer and activator of transcription 6 down-regulates toll-like receptor-4 expression of a monocytic cell line by Fiset, P. O., Tulic, M. K., Skrablin, P. S. A., Grover, S. M., Létuvé, S., Mazer, B. D., Hamid, Q.

“…Summary Background Toll‐like receptor 4 (TLR4), part of the bacterial lipopolysaccharide (LPS) receptor, is an important bridge between innate and adaptive…”
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Efficient purification of eosinophils from human tissues: A comparative study by Nissim Ben Efraim, A.H., Munitz, A., Sherman, Y., Mazer, B.D., Levi-Schaffer, F., Eliashar, R.

“…Eosinophils are key effector cells in allergy and in other inflammatory diseases. Although they carry out their function in the tissues, no efficient method…”
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TGF-β-mediated airway tolerance to allergens induced by peptide-based immunomodulatory mucosal vaccination by Michael, H, Li, Y, Wang, Y, Xue, D, Shan, J, Mazer, B D, McCusker, C T

“…We sought to modulate mucosal immune responses using neonatal vaccination to avert the development of allergic airways disease (AAD). Pulmonary pathology in…”
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Functional Expression of IL-12 Receptor by Human Eosinophils: IL-12 Promotes Eosinophil Apoptosis by Nutku, Esra, Zhuang, Qianli, Soussi-Gounni, Abdelillah, Aris, Fadi, Mazer, Bruce D, Hamid, Qutayba

“…In murine models of allergic inflammation, IL-12 has been shown to decrease tissue eosinophilia, but the underlying mechanisms are not known. We evaluated the…”
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An open-label study of high-dose intravenous immunoglobulin in severe childhood asthma by Mazer, B D, Gelfand, E W

“…Eight pediatric patients with severe steroid-dependent asthma were enrolled in an open-label trial of high-dose intravenous immunoglobulin (IVIG) in an attempt…”
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Children with atopic histories exhibit impaired lipopolysaccharide-induced Toll-like receptor-4 signalling in peripheral monocytes by Préfontaine, D., Banville-Langelier, A.-A., Fiset, P.-O., Guay, J., An, J., Mazer, M., Hamid, Q., Mazer, B. D.

“…Summary Background The hygiene hypothesis states that early exposure to bacterial products such as lipopolysaccharide (LPS) may be protective against the…”
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Activation Via Multiple Signaling Pathways Induces Down-Regulation of Platelet-Activating Factor Receptors on Human B Lymphocytes by Zhuang, Qianli, Bastien, Yolande, Mazer, Bruce D

“…Platelet-activating factor receptor (PAFR) has been identified in B cell lines and primary human B cells, but the regulation of PAFR during B cell activation…”
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Atopy affects LPS responsiveness and TLR-4 expression in children peripheral mononuclear cells by Préfontaine, D, Banville-Langelier, AA, Fiset, PO, Guay, J, Hamid, Q, Mazer, BD

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Similar allergic inflammation in the middle ear and the upper airway: Evidence linking otitis media with effusion to the united airways concept by Nguyen, Lily H.P., Manoukian, John J., Sobol, Steven E., Tewfik, Ted L., Mazer, Bruce D., Schloss, Melvin D., Taha, Rame, Hamid, Qutayba A.

“…Otitis media with effusion (OME) is a chronic inflammatory disease of the middle ear space characterized by the accumulation of fluid. Previous investigations…”
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Synthesis of IL-13 by human B lymphocytes: Regulation and role in IgE production by Hajoui, Oumnia, Janani, Ramesh, Tulic, Meri, Joubert, Philippe, Ronis, Tova, Hamid, Qutayba, Zheng, Huaien, Mazer, Bruce D.

“…Our laboratory has demonstrated previously that human tonsillar B lymphocytes express IL-13 mRNA We sought to investigate IL-13 production by human B cells and…”
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Dose-dependent agonist and antagonist effects of the platelet-activating factor analogue 1-palmitoyl-2-acetoyl- sn-glycero-3-phosphocholine on B lymphocytes by Mazer, Bruce D., Toledano, Baruch, Saririan, Mehrdad, Bastien, Yolande

“…Background: Platelet activating-factor (PAF), an ether-linked phospholipid, is a potent activator of B lymphocyte cell lines. The related ester-linked…”
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Use of intravenous immunoglobulin in human disease: A review of evidence by members of the Primary Immunodeficiency Committee of the American Academy of Allergy, Asthma and Immunology by Orange, Jordan S., Hossny, Elham M., Weiler, Catherine R., Ballow, Mark, Berger, Melvin, Bonilla, Francisco A., Buckley, Rebecca, Chinen, Javier, El-Gamal, Yehia, Mazer, Bruce D., Nelson, Robert P., Patel, Dhavalkumar D., Secord, Elizabeth, Sorensen, Ricardo U., Wasserman, Richard L., Cunningham-Rundles, Charlotte

“…Human immunoglobulin prepared for intravenous administration (IGIV) has a number of important uses in the treatment of disease. Some of these are in diseases…”
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Autocrine stimulation of B lymphocytes by platelet-activating factor receptor agonist, 1-palmitoyl-2-acetoyl-sn-glycero-3-phosphocholine by TORDAI, A, FRANKLIN, R. A, JOHNSON, C, MAZER, B. D, CLAY, K. L, GELFAND, E. W

“…Based on previous data which demonstrated the ability of platelet-activating factor (PAF) antagonists to inhibit constitutive immunoglobulin synthesis in…”
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B-cell activation and regulation of immunoglobulin synthesis by platelet activating factor by Mazer, B D, Sawami, H, Franklin, R, Gelfand, E W

“…Platelet activating factor (PAF) is a highly potent phospholipid mediator known to be active in many biologic systems. To date little is known of the effect of…”
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An ELISA spot assay for quantitation of human immunoglobulin-secreting cells by Mazer, B D, Renz, H, Gelfand, E W

“…The elucidation of changes in populations of immunoglobulin-secreting cells has been a cumbersome process. We present a simplified method for the enumeration…”
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Immune function in autistic children by Stern, Lara, Francoeur, Marie-Josée, Primeau, Marie-Noel, Sommerville, Wendy, Fombonne, Eric, Mazer, Bruce D

“…There have been reports that some children with autistic spectrum disorders have abnormal immune function. However, data in this area remain scarce and…”
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Remission of interstitial lung disease following therapy of associated ulcerative colitis by Mazer, B D, Eigen, H, Gelfand, E W, Brugman, S M

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Absence of ZAP-70 prevents signaling through the antigen receptor on peripheral blood T cells but not on thymocytes by Gelfand, E W, Weinberg, K, Mazer, B D, Kadlecek, T A, Weiss, A

“…Recently, a severe combined immunodeficiency syndrome with a deficiency of CD8+ peripheral T cells and a TCR signal transduction defect in peripheral CD4+ T…”
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