Search Results - "Mayranpaa, MI"

Increased type 1 inflammation in gynecologic cervicovaginal samples in patients with APS-1 by Hetemäki, Iivo, Saari, Viivi, Yohannes, Dawit A., Holopainen, Elina, Holster, Tiina, Jokiranta, Suvi, Mäyränpää, Mikko I., Virtanen, Seppo, Mäkitie, Outi, Kekäläinen, Eliisa, Laakso, Saila

“…Inborn errors of immunity offer important insights into mucosal immunity. In autoimmune polyendocrine syndrome type-1 (APS-1), chronic mucocutaneous…”
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Dysregulated germinal center reaction with expanded T follicular helper cells in autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy lymph nodes by Hetemäki, Iivo, Sarkkinen, Joona, Heikkilä, Nelli, Drechsel, Karen, Mäyränpää, Mikko I., Färkkilä, Anniina, Laakso, Saila, Mäkitie, Outi, Arstila, T. Petteri, Kekäläinen, Eliisa

“…Autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy (APECED, also called APS-1) is an inborn error of immunity with clear signs of B-cell…”
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Pubertal development and hypogonadism in males with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy: a retrospective study by Träskilä, Emilia, Holopainen, Elina, Mäyränpää, Mikko I, Toppari, Jorma, Mäkitie, Outi, Laakso, Saila

“…The aim of this study was to describe the course of puberty and hypogonadism in males with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy…”
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Prognostic Role of Tumor Immune Microenvironment in Pleural Epithelioid Mesothelioma by Ollila, Hely, Mäyränpää, Mikko I., Paavolainen, Lassi, Paajanen, Juuso, Välimäki, Katja, Sutinen, Eva, Wolff, Henrik, Räsänen, Jari, Kallioniemi, Olli, Myllärniemi, Marjukka, Ilonen, Ilkka, Pellinen, Teijo

“…BackgroundPleural mesothelioma (MPM) is an aggressive malignancy with an average patient survival of only 10 months. Interestingly, about 5%-10% of the…”
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Increased type 7 inflammation in gynecologic cervicovaginal samples in patients with APS-7 by Hetemaki, I, Saari, V, Yohannes, DA, Holopainen, E, Holster, T, Jokiranta, S, Mayranpaa, MI, Virtanen, S, Makitie, O, Kekalainen, E

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Reduction in mucosal-associated invariant T cells (MAIT) in APECED patients is associated with elevated serum IFN-γ concentration by Hetemäki, Iivo, Sarkkinen, Joona, Wong, Huai Hui, Heikkilä, Nelli, Laakso, Saila, Miettinen, Simo, Mäyränpää, Mikko I, Mäkitie, Outi, Arstila, T Petteri, Kekäläinen, Eliisa

“…Mucosal-associated invariant T cells (MAIT) are innate-like lymphocytes enriched in mucosal organs where they contribute to antimicrobial defense. APECED is an…”
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Mast Cells: Important Players in the Orchestrated Pathogenesis of Abdominal Aortic Aneurysms by Swedenborg, Jesper, Mäyränpää, Mikko I, Kovanen, Petri T

“…Mast cells (MCs) regulate inflammation and immunity. Their granular content includes heparin, histamine, and several enzymes (tryptase, chymase,…”
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Novel therapeutic approaches for pleural mesothelioma identified by functional ex vivo drug sensitivity testing by Ollila-Raj, Hely, Murumägi, Astrid, Pellinen, Teijo, Arjama, Mariliina, Sutinen, Eva, Volmonen, Kirsi, Haikala, Heidi M., Kallioniemi, Olli, Mäyränpää, Mikko I., Ilonen, Ilkka

“…•Standard of care for pleural mesothelioma has not changed for 20 years.•Repurposing of already approved drugs may result in more effective…”
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Imatinib treatment attenuates growth and inflammation of angiotensin II induced abdominal aortic aneurysm by Vorkapic, Emina, Dugic, Elma, Vikingsson, Svante, Roy, Joy, Mäyränpää, Mikko I, Eriksson, Per, Wågsäter, Dick

“…Abstract Background Abdominal aortic aneurysm (AAA) is characterized by vascular remodeling with increased infiltration of inflammatory cells and…”
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Human mast cell neutral proteases generate modified LDL particles with increased proteoglycan binding by Maaninka, Katariina, Nguyen, Su Duy, Mäyränpää, Mikko I., Plihtari, Riia, Rajamäki, Kristiina, Lindsberg, Perttu J., Kovanen, Petri T., Öörni, Katariina

“…Subendothelial interaction of LDL with extracellular matrix drives atherogenesis. This interaction can be strengthened by proteolytic modification of LDL. Mast…”
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TRIF adaptor signaling is important in abdominal aortic aneurysm formation by Vorkapic, Emina, Lundberg, Anna M, Mäyränpää, Mikko I, Eriksson, Per, Wågsäter, Dick

“…Abstract Objective Abdominal aortic aneurysm (AAA) is characterized by inflammation, loss of smooth muscle cells (SMCs), and degradation of the extracellular…”
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Cell of Origin Links Histotype Spectrum to Immune Microenvironment Diversity in Non-small-Cell Lung Cancer Driven by Mutant Kras and Loss of Lkb1 by Nagaraj, Ashwini S., Lahtela, Jenni, Hemmes, Annabrita, Pellinen, Teijo, Blom, Sami, Devlin, Jennifer R., Salmenkivi, Kaisa, Kallioniemi, Olli, Mäyränpää, Mikko I., Närhi, Katja, Verschuren, Emmy W.

“…Lung cancers exhibit pronounced functional heterogeneity, confounding precision medicine. We studied how the cell of origin contributes to phenotypic…”
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Spatial aspects of oncogenic signalling determine the response to combination therapy in slice explants from Kras‐driven lung tumours by Närhi, Katja, Nagaraj, Ashwini S, Parri, Elina, Turkki, Riku, van Duijn, Petra W, Hemmes, Annabrita, Lahtela, Jenni, Uotinen, Virva, Mäyränpää, Mikko I, Salmenkivi, Kaisa, Räsänen, Jari, Linder, Nina, Trapman, Jan, Rannikko, Antti, Kallioniemi, Olli, Af Hällström, Taija M, Lundin, Johan, Sommergruber, Wolfgang, Anders, Simon, Verschuren, Emmy W

“…A key question in precision medicine is how functional heterogeneity in solid tumours informs therapeutic sensitivity. We demonstrate that spatial…”
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Loss-of-function mutation in IKZF2 leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cells by Hetemäki, Iivo, Kaustio, Meri, Kinnunen, Matias, Heikkilä, Nelli, Keskitalo, Salla, Nowlan, Kirsten, Miettinen, Simo, Sarkkinen, Joona, Glumoff, Virpi, Andersson, Noora, Kettunen, Kaisa, Vanhanen, Reetta, Nurmi, Katariina, Eklund, Kari K, Dunkel, Johannes, Mäyränpää, Mikko I, Schlums, Heinrich, Arstila, T Petteri, Kisand, Kai, Bryceson, Yenan T, Peterson, Pärt, Otava, Ulla, Syrjänen, Jaana, Saarela, Janna, Varjosalo, Markku, Kekäläinen, Eliisa

“…The Ikaros family transcription factors regulate lymphocyte development. Loss-of-function variants in cause primary immunodeficiency, but Ikaros family members…”
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Spatial aspects of oncogenic signalling determine the response to combination therapy in slice explants from Kras‐driven lung tumours by Narhi, K, Nagaraj, AS, Parri, E, Turkki, R, van Duijn, PW, Hemmes, A, Lahtela, J, Uotinen, V, Mayranpaa, MI, Salmenkivi, K, Rasanen, J, Linder, N, Trapman, J, Rannikko, A, Kallioniemi, O, Af Hallstrom, TM, Lundin, J, Sommergruber, W, Anders, S, Verschuren, EW

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Mast cells associate with neovessels in the media and adventitia of abdominal aortic aneurysms by Mäyränpää, Mikko I., MD, PhD, Trosien, Julia A., MSc, Fontaine, Vincent, MD, PhD, Folkesson, Maggie, MSc, Kazi, Monsur, MD, PhD, Eriksson, Per, PhD, Swedenborg, Jesper, MD, PhD, Hedin, Ulf, MD, PhD

“…Objective Mast cells (MCs) are inflammatory cells present in atherosclerotic lesions and neovascularized tissues. Recently, MCs were shown to modulate…”
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Increased expression of leukotriene C₄ synthase and predominant formation of cysteinyl-leukotrienes in human abdominal aortic aneurysm by Di Gennaro, Antonio, Wågsäter, Dick, Mäyränpää, Mikko I, Gabrielsen, Anders, Swedenborg, Jesper, Hamsten, Anders, Samuelsson, Bengt, Eriksson, Per, Haeggström, Jesper Z

“…Leukotrienes (LTs) are arachidonic acid-derived lipid mediators involved in the pathogenesis and progression of diverse inflammatory disorders. The…”
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High tumor cell platelet‐derived growth factor receptor beta expression is associated with shorter survival in malignant pleural epithelioid mesothelioma by Ollila, Hely, Paajanen, Juuso, Wolff, Henrik, Ilonen, Ilkka, Sutinen, Eva, Välimäki, Katja, Östman, Arne, Anttila, Sisko, Kettunen, Eeva, Räsänen, Jari, Kallioniemi, Olli, Myllärniemi, Marjukka, Mäyränpää, Mikko I, Pellinen, Teijo

“…Malignant pleural mesothelioma (MPM) has a rich stromal component containing mesenchymal fibroblasts. However, the properties and interplay of MPM tumor cells…”
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Serine protease inhibitor A3 in atherosclerosis and aneurysm disease by WÅGSÄTER, DICK, JOHANSSON, DANIEL, FONTAINE, VINCENT, VORKAPIC, EMINA, BÄCKLUND, ALEXANDRA, RAZUVAEV, ANTON, MÄYRÄNPÄÄ, MIKKO I, HJERPE, CHARLOTTA, CAIDAHL, KENNETH, HAMSTEN, ANDERS, FRANCO-CERECEDA, ANDERS, WILBERTZ, JOHANNES, SWEDENBORG, JESPER, ZHOU, XINGHUA, ERIKSSON, PER

“…Remodeling of extracellular matrix (ECM) plays an important role in both atherosclerosis and aneurysm disease. Serine protease inhibitor A3 (serpinA3) is an…”
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Bone densitometry in the diagnosis of vertebral fractures in children: Accuracy of vertebral fracture assessment by Mäyränpää, Mervi K, Helenius, Ilkka, Valta, Helena, Mäyränpää, Mikko I, Toiviainen-Salo, Sanna, Mäkitie, Outi

“…Abstract Background: DXA scanner derived images of the spine are used for vertebral fracture detection in adults. It is unknown whether the method could be…”
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