Search Results - "Mayor Ruiz, Cristina"

Biophysical and Computational Approaches to Study Ternary Complexes: A ‘Cooperative Relationship’ to Rationalize Targeted Protein Degradation by Ward, Jake A., Perez‐Lopez, Carles, Mayor‐Ruiz, Cristina

“…Degraders have illustrated that compound‐induced proximity to E3 ubiquitin ligases can prompt the ubiquitination and degradation of disease‐relevant proteins…”
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Discovery and Mechanistic Elucidation of NQO1‐Bioactivatable Small Molecules That Overcome Resistance to Degraders by Barbosa, Bárbara M. G., Sfyaki, Aikaterini, Rafael, Sergi, José‐Duran, Ferran, Pous, Joan, Sánchez‐Zarzalejo, Carolina, Perez‐Lopez, Carles, Vilanova, Mar, Cigler, Marko, Gay, Marina, Vilaseca, Marta, Winter, Georg E., Riera, Antoni, Mayor‐Ruiz, Cristina

“…Degraders hold the promise to efficiently inactivate previously intractable disease‐relevant targets. Unlike traditional inhibitors, degraders act…”
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Rational discovery of molecular glue degraders via scalable chemical profiling by Mayor-Ruiz, Cristina, Bauer, Sophie, Brand, Matthias, Kozicka, Zuzanna, Siklos, Marton, Imrichova, Hana, Kaltheuner, Ines H., Hahn, Elisa, Seiler, Kristina, Koren, Anna, Petzold, Georg, Fellner, Michaela, Bock, Christoph, Müller, André C., Zuber, Johannes, Geyer, Matthias, Thomä, Nicolas H., Kubicek, Stefan, Winter, Georg E.

“…Targeted protein degradation is a new therapeutic modality based on drugs that destabilize proteins by inducing their proximity to E3 ubiquitin ligases. Of…”
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Structural Equation Models on the Satisfaction and Motivation for Retirement of Spanish University Professors by Romero Tena, Rosalía, Mayor Ruiz, Cristina, Yot Domínguez, Carmen, Chaves Maza, Manuel

“…Research on the motives behind a university professor’s decision to retire is scarce. In the present work, we have tried to define and delimit the aspects of…”
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Plasticity of the Cullin-RING Ligase Repertoire Shapes Sensitivity to Ligand-Induced Protein Degradation by Mayor-Ruiz, Cristina, Jaeger, Martin G., Bauer, Sophie, Brand, Matthias, Sin, Celine, Hanzl, Alexander, Mueller, André C., Menche, Jörg, Winter, Georg E.

“…Inducing protein degradation via small molecules is a transformative therapeutic paradigm. Although structural requirements of target degradation are emerging,…”
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A p53-dependent response limits the viability of mammalian haploid cells by Olbrich, Teresa, Mayor-Ruiz, Cristina, Vega-Sendino, Maria, Gomez, Carmen, Ortega, Sagrario, Ruiz, Sergio, Fernandez-Capetillo, Oscar

“…The recent development of haploid cell lines has facilitated forward genetic screenings in mammalian cells. These lines include near-haploid human cell lines…”
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Inside Cover: Discovery and Mechanistic Elucidation of NQO1‐Bioactivatable Small Molecules That Overcome Resistance to Degraders (Angew. Chem. Int. Ed. 12/2024) by Barbosa, Bárbara M. G., Sfyaki, Aikaterini, Rafael, Sergi, José‐Duran, Ferran, Pous, Joan, Sánchez‐Zarzalejo, Carolina, Perez‐Lopez, Carles, Vilanova, Mar, Cigler, Marko, Gay, Marina, Vilaseca, Marta, Winter, Georg E., Riera, Antoni, Mayor‐Ruiz, Cristina

“…Multiomics‐driven elucidation of RBS‐10 as a prodrug bioactivated by the enzyme NQO1 is reported by Antoni Riera, Cristina Mayor‐Ruiz et al. in their Research…”
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The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity by Winter, Georg E, Radic, Branka, Mayor-Ruiz, Cristina, Blomen, Vincent A, Trefzer, Claudia, Kandasamy, Richard K, Huber, Kilian V M, Gridling, Manuela, Chen, Doris, Klampfl, Thorsten, Kralovics, Robert, Kubicek, Stefan, Fernandez-Capetillo, Oscar, Brummelkamp, Thijn R, Superti-Furga, Giulio

“…A haploid screen in human cells identified the solute carrier protein family member, SLC35F2, as a determinant of the sensitivity of cells to the DNA damaging…”
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Perfil lector de los estudiantes de Secundaria de la República Dominicana by Espaillat, Cristina Amiama, Ruiz, Cristina Mayor

“…La Educación Secundaria en la República Dominicana se puede convertir en un obstáculo para que sus ciudadanos se inserten de forma competitiva en la economía…”
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Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway by González, Lorena, Díaz, Lucía, Pous, Joan, Baginski, Blazej, Duran-Corbera, Anna, Scarpa, Margherita, Brun-Heath, Isabelle, Igea, Ana, Martin-Malpartida, Pau, Ruiz, Lidia, Pallara, Chiara, Esguerra, Mauricio, Colizzi, Francesco, Mayor-Ruiz, Cristina, Biondi, Ricardo M., Soliva, Robert, Macias, Maria J., Orozco, Modesto, Nebreda, Angel R.

“…p38α is a versatile protein kinase that can control numerous processes and plays important roles in the cellular responses to stress. Dysregulation of p38α…”
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Discovery and Mechanistic Elucidation of NQO1‐Bioactivatable Small Molecules That Overcome Resistance to Degraders by Barbosa, Bárbara M. G., Sfyaki, Aikaterini, Rafael, Sergi, José‐Duran, Ferran, Pous, Joan, Sánchez‐Zarzalejo, Carolina, Perez‐Lopez, Carles, Vilanova, Mar, Cigler, Marko, Gay, Marina, Vilaseca, Marta, Winter, Georg E., Riera, Antoni, Mayor‐Ruiz, Cristina

“…Degraders hold the promise to efficiently inactivate previously intractable disease‐relevant targets. Unlike traditional inhibitors, degraders act…”
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Innentitelbild: Discovery and Mechanistic Elucidation of NQO1‐Bioactivatable Small Molecules That Overcome Resistance to Degraders (Angew. Chem. 12/2024) by Barbosa, Bárbara M. G., Sfyaki, Aikaterini, Rafael, Sergi, José‐Duran, Ferran, Pous, Joan, Sánchez‐Zarzalejo, Carolina, Perez‐Lopez, Carles, Vilanova, Mar, Cigler, Marko, Gay, Marina, Vilaseca, Marta, Winter, Georg E., Riera, Antoni, Mayor‐Ruiz, Cristina

“…Multiomics‐driven elucidation of RBS‐10 as a prodrug bioactivated by the enzyme NQO1 is reported by Antoni Riera, Cristina Mayor‐Ruiz et al. in their Research…”
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Analysing the relationship between reading fluency and reading competence in Secondary Education by Cristina Amiama-Espaillat, Cristina Mayor-Ruiz

“…An adequate level of reading competence is essential to exercise fundamental rights in the hyperconnected information society of the 21st century. Reading…”
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La evaluación del profesorado universitario: una mirada del estudiantado by Valentín-Martínez, Bilda, Mayor-Ruiz, Cristina

“…Resumen El presente artículo tiene como objetivo principal analizar la percepción que tienen los estudiantes del sistema de evaluación del profesorado en sus…”
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The professional identity of young university lecturers by Ángela Martín-Gutiérrez, Jesús Conde-Jiménez, Cristina Mayor-Ruiz

“…This article presents the experience of a teaching team, which is located in the Faculty of Education at the University of Seville. This team consists of three…”
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Retraso en la jubilación de académicos Chilenos: Una visión de sus percepciones ante el futuro by Mayor Ruiz, Cristina, Sánchez Brkic, Daniel

“…El objetivo del presente artículo es dar cuenta de los resultados de una investigación doctoral actualmente finalizada cuyo objetivo es conocer las causas por…”
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Chemical rewiring of ubiquitination by degraders and their selectivity routes by Whelan, Rory, Mayor-Ruiz, Cristina

“…Ubiquitination is an essential process that curtails cellular levels of damaged and redundant proteins. Chemical biologists have harnessed this natural system…”
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Explorando la relación entre fluidez lectora y competencia lectora en Educación Secundaria by Amiama-Espaillat, Cristina, Mayor-Ruiz, Cristina

“…Un nivel adecuado de competencia lectora es esencial para ejercer los derechos fundamentales en la sociedad de la información hiperconectada del siglo XXI. La…”
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La identidad profesional docente del profesorado novel universitario by Martín-Gutiérrez, Ángela, Conde-Jiménez, Jesús, Mayor-Ruiz, Cristina

“…En este artículo se presenta la experiencia de un equipo docente, ubicado en la Facultad de Ciencias de la Educación de la Universidad de Sevilla, constituido…”
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Evaluación de competencias matemáticas específicas en la formación de profesores de Educación Media en Chile by Quiroz Meza, Alonso Benjamin, Mayor Ruiz, Cristina

“…En este artículo, se identifican temáticas y se describen propuestas efectuadas por formadores de profesores de matemáticas, respecto de estrategias para su…”
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