Search Results - "Mayo, Olga Barca"
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Deletion of astrocytic BMAL1 results in metabolic imbalance and shorter lifespan in mice
Published in Glia (01-06-2020)“…Disruption of the circadian cycle is strongly associated with metabolic imbalance and reduced longevity in humans. Also, rodent models of circadian arrhythmia,…”
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Astrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signalling
Published in Nature communications (10-02-2017)“…Circadian rhythms are controlled by a network of clock neurons in the central pacemaker, the suprachiasmatic nucleus (SCN). Core clock genes, such as Bmal1 ,…”
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DELETION OF ASTROCYTIC BMAL1 RESULTS IN METABOLIC IMBALANCE AND SHORTER LIFESPAN IN MICE
Published in IBRO neuroscience reports (01-10-2023)Get full text
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Astrocyte Clocks and Glucose Homeostasis
Published in Frontiers in endocrinology (Lausanne) (18-03-2021)“…The endogenous timekeeping system evolved to anticipate the time of the day through the 24 hours cycle of the Earth's rotation. In mammals, the circadian clock…”
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Astrocytes and Circadian Rhythms: An Emerging Astrocyte-Neuron Synergy in the Timekeeping System
Published in Methods in molecular biology (Clifton, N.J.) (2019)“…Animals have an internal timekeeping system to anticipate daily changes associated with the transition of day to night, which is deeply involved in the…”
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Astrocytes actively support long-range molecular clock synchronization of segregated neuronal populations
Published in Scientific reports (24-03-2023)“…In mammals, the suprachiasmatic nucleus of the hypothalamus is the master circadian pacemaker that synchronizes the clocks in the central nervous system and…”
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Astrocytic insulin receptor controls circadian behavior via dopamine signaling in a sexually dimorphic manner
Published in Nature communications (09-12-2023)“…Mammalian circadian clocks respond to feeding and light cues, adjusting internal rhythms with day/night cycles. Astrocytes serve as circadian timekeepers,…”
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Glial Bmal1 role in mammalian retina daily changes
Published in Scientific reports (13-12-2022)“…Visual information processing in the retina requires the rhythmic expression of clock genes. The intrinsic retinal circadian clock is independent of the master…”
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Hypothalamic astrocytic-BMAL1 regulates energy homeostasis in a sex-dependent manner
Published in Cell reports (Cambridge) (29-08-2023)“…Here, we demonstrate that hypothalamic astrocytic BMAL1 computes cyclic metabolic information to optimize energetic resources in a sexually dimorphic manner…”
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Mice Deficient in Dual Oxidase Maturation Factors Are Severely Hypothyroid
Published in Molecular endocrinology (Baltimore, Md.) (01-03-2012)“…Dual oxidases (DUOX1 and DUOX2) are evolutionary conserved reduced nicotinamide adenine dinucleotide phosphate oxidases responsible for regulated hydrogen…”
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Temperature modulates systemic and central actions of thyroid hormones on BAT thermogenesis
Published in Frontiers in physiology (18-11-2022)“…Thyroid hormones (THs) play a major role regulating energy balance and brown adipose tissue (BAT) thermogenesis, as well as body temperature, as shown in…”
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Hypothalamic free fatty acid receptor-1 regulates whole-body energy balance
Published in Molecular metabolism (Germany) (01-01-2024)“…Free fatty acid receptor-1 (FFAR1) is a medium- and long-chain fatty acid sensing G protein-coupled receptor that is highly expressed in the hypothalamus…”
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Protocol for ovariectomy and estradiol replacement in mice
Published in STAR protocols (15-03-2024)“…Ovariectomy, involving the surgical removal of ovaries, and estradiol replacement facilitate the understanding of sexual dimorphism-related physiological…”
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Role of type 2 deiodinase in response to acute lung injury (ALI) in mice
Published in Proceedings of the National Academy of Sciences - PNAS (06-12-2011)“…Thyroid hormone (TH) metabolism, mediated by deiodinase types 1, 2, and 3 (D1, D2, and D3) is profoundly affected by acute illness. We examined the role of TH…”
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Estradiol and leptin: no engagement without CITED1
Published in Trends in endocrinology and metabolism (01-07-2023)“…Ovarian estradiol and leptin are important modulators of whole-body energy homeostasis that act in the hypothalamus. In a recent paper in Cell Metabolism,…”
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Convergent microRNA actions coordinate neocortical development
Published in Cellular and molecular life sciences : CMLS (01-08-2014)“…Neocortical development is a complex process that, at the cellular level, involves tight control of self-renewal, cell fate commitment, survival,…”
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LC–MS/MS analysis of twelve neurotransmitters and amino acids in mouse cerebrospinal fluid
Published in Journal of neuroscience methods (15-07-2020)“…•Novel method for the analysis of 12 neuroactive molecules from mouse cerebrospinal fluid (CSF).•The method couples a dedicated surgical procedure with…”
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Thyroid Hormone Receptor α and Regulation of Type 3 Deiodinase
Published in Molecular endocrinology (Baltimore, Md.) (01-04-2011)“…Thyroid hormone metabolism regulated by deiodinase type 3 is dependent on the thyroid hormone receptor alpha isoform. Mice deficient in thyroid hormone…”
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Fine-Tuning Oligodendrocyte Development by microRNAs
Published in Frontiers in neuroscience (01-01-2012)“…Myelination of axons by oligodendrocytes in the central nervous system is essential for normal neuronal functions. The failure of remyelination due to injury…”
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Thyroid Hormone Receptor α and Regulation of Type 3 Deiodinase
Published in The journal of clinical endocrinology and metabolism (01-03-2011)“…This article appears in Molecular Endocrinology, published February 3, 2011, 10.1210/me.2010-0213…”
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