Search Results - "Mayo, Juan"

Melatonin as an antioxidant: under promises but over delivers by Reiter, Russel J., Mayo, Juan C., Tan, Dun-Xian, Sainz, Rosa M., Alatorre-Jimenez, Moises, Qin, Lilan

“…Melatonin is uncommonly effective in reducing oxidative stress under a remarkably large number of circumstances. It achieves this action via a variety of…”
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Redox Signaling and Advanced Glycation Endproducts (AGEs) in Diet-Related Diseases by Cepas, Vanesa, Collino, Massimo, Mayo, Juan C, Sainz, Rosa M

“…Diets are currently characterized by elevated sugar intake, mainly due to the increased consumption of processed sweetened foods and drinks during the last 40…”
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Influence of Inflammation in the Process of T Lymphocyte Differentiation: Proliferative, Metabolic, and Oxidative Changes by Moro-García, Marco A, Mayo, Juan C, Sainz, Rosa M, Alonso-Arias, Rebeca

“…T lymphocytes, from their first encounter with their specific antigen as naïve cell until the last stages of their differentiation, in a replicative state of…”
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The dark side of glucose transporters in prostate cancer: Are they a new feature to characterize carcinomas? by Gonzalez‐Menendez, Pedro, Hevia, David, Mayo, Juan C., Sainz, Rosa M.

“…One of the hallmarks of cancer cells is the increased ability to acquire nutrients, particularly glucose and glutamine. Proliferating cells need precursors for…”
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Melatonin transport into mitochondria by Mayo, Juan C., Sainz, Rosa M., González-Menéndez, Pedro, Hevia, David, Cernuda-Cernuda, Rafael

“…Melatonin is a well-known, nighttime-produced indole found in bacteria, eukaryotic unicellulars, animals or vascular plants. In vertebrates, melatonin is the…”
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Manganese superoxide dismutase (SOD2/MnSOD)/catalase and SOD2/GPx1 ratios as biomarkers for tumor progression and metastasis in prostate, colon, and lung cancer by Miar, Ana, Hevia, David, Muñoz-Cimadevilla, Henar, Astudillo, Aurora, Velasco, Julio, Sainz, Rosa M., Mayo, Juan C.

“…The role of manganese-dependent superoxide dismutase (SOD2/MnSOD) during tumor progression has been studied for several decades with controversial results…”
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Melatonin and sirtuins: A “not‐so unexpected” relationship by Mayo, Juan C., Sainz, Rosa M., González Menéndez, Pedro, Cepas, Vanesa, Tan, Dun‐Xian, Reiter, Russel J.

“…Epigenetic modifications, including methylation or acetylation as well as post‐transcriptional modifications, are mechanisms used by eukaryotic cells to…”
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Carbon Quantum Dots Codoped with Nitrogen and Lanthanides for Multimodal Imaging by Bouzas‐Ramos, Diego, Cigales Canga, Jesus, Mayo, Juan Carlos, Sainz, Rosa Maria, Ruiz Encinar, Jorge, Costa‐Fernandez, Jose Manuel

“…Nanoparticles are increasingly being used as advantageous alternatives to commonly used contrast agents in bioimaging, not only due to their improved imaging…”
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Melatonin and Reproduction Revisited by Reiter, Russel J, Tan, Dun-Xian, Manchester, Lucien C, Paredes, Sergio D, Mayo, Juan C, Sainz, Rosa M

“…This brief review summarizes new findings related to the reported beneficial effects of melatonin on reproductive physiology beyond its now well-known role in…”
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GLUT1 protects prostate cancer cells from glucose deprivation-induced oxidative stress by Gonzalez-Menendez, Pedro, Hevia, David, Alonso-Arias, Rebeca, Alvarez-Artime, Alejandro, Rodriguez-Garcia, Aida, Kinet, Sandrina, Gonzalez-Pola, Ivan, Taylor, Naomi, Mayo, Juan C., Sainz, Rosa M.

“…Glucose, chief metabolic support for cancer cell survival and growth, is mainly imported into cells by facilitated glucose transporters (GLUTs). The increase…”
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Melatonin from an Antioxidant to a Classic Hormone or a Tissue Factor: Experimental and Clinical Aspects 2019 by Mayo, Juan C, Sainz, Rosa M

“…During the last 25 years we have accomplished great advances in melatonin research, regarding antioxidant or anti-inflammatory functions, oncostatic actions,…”
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Melatonin uptake through glucose transporters: a new target for melatonin inhibition of cancer by Hevia, David, González-Menéndez, Pedro, Quiros-González, Isabel, Miar, Ana, Rodríguez-García, Aida, Tan, Dun-Xian, Reiter, Russel J., Mayo, Juan C., Sainz, Rosa M.

“…Melatonin is present in a multitude of taxa and it has a broad range of biological functions, from synchronizing circadian rhythms to detoxifying free…”
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The changing biological roles of melatonin during evolution: from an antioxidant to signals of darkness, sexual selection and fitness by Tan, Dun-Xian, Hardeland, Rüdiger, Manchester, Lucien C., Paredes, Sergio D., Korkmaz, Ahmet, Sainz, Rosa M., Mayo, Juan C., Fuentes-Broto, Lorena, Reiter, Russel J.

“…Melatonin is a molecule present in a multitude of taxa and may be ubiquitous in organisms. It has been found in bacteria, unicellular eukaryotes, macroalgae,…”
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Melatonin-Induced Cytoskeleton Reorganization Leads to Inhibition of Melanoma Cancer Cell Proliferation by Alvarez-Artime, Alejandro, Cernuda-Cernuda, Rafael, Francisco-Artime-Naveda, Cepas, Vanesa, Gonzalez-Menendez, Pedro, Fernadez-Vega, Sheila, Quiros-Gonzalez, Isabel, Sainz, Rosa M, Mayo, Juan C

“…Neuroindole melatonin, a hormone synthesized during the night mainly-but not exclusively-by the pineal gland of all vertebrates, functions as an adapting…”
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Reflections on the Biology of Cell Culture Models: Living on the Edge of Oxidative Metabolism in Cancer Cells by Moran-Alvarez, Alba, Gonzalez-Menendez, Pedro, Mayo, Juan C, Sainz, Rosa M

“…Nowadays, the study of cell metabolism is a hot topic in cancer research. Many studies have used 2D conventional cell cultures for their simplicity and the…”
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Regulation of GLUT Transporters by Flavonoids in Androgen-Sensitive and -Insensitive Prostate Cancer Cells by Gonzalez-Menendez, Pedro, Hevia, David, Rodriguez-Garcia, Aida, Mayo, Juan C, Sainz, Rosa M

“…Cancer cells show different metabolic requirements from normal cells. In prostate cancer, particularly, glycolytic metabolism differs in androgen-responsive…”
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IGFBP3 and MAPK/ERK signaling mediates melatonin‐induced antitumor activity in prostate cancer by Mayo, Juan C., Hevia, David, Quiros‐Gonzalez, Isabel, Rodriguez‐Garcia, Aida, Gonzalez‐Menendez, Pedro, Cepas, Vanesa, Gonzalez‐Pola, Iván, Sainz, Rosa M.

“…Treatment of prostate cancer (PCa), a leading cause of cancer among males, lacks successful strategies especially in advanced, hormone‐refractory stages. Some…”
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Baricitinib reduces 30‐day mortality in older adults with moderate‐to‐severe COVID‐19 pneumonia by Abizanda, Pedro, Calbo Mayo, Juan María, Mas Romero, Marta, Cortés Zamora, Elisa Belén, Tabernero Sahuquillo, María Teresa, Romero Rizos, Luis, Sánchez‐Jurado, Pedro Manuel, Sánchez‐Nievas, Ginés, Campayo Escolano, Carlos, Ochoa Serrano, Alba, Sánchez‐Flor Alfaro, Victoria, López Bru, Rita, Gómez Ballesteros, Cristina, Caldevilla Bernardo, David, Callejas González, Francisco Javier, Andrés‐Pretel, Fernando, Lauschke, Volker Martin, Stebbing, Justin

“…Background Older adults are at the highest risk of severe disease and death due to COVID‐19. Randomized data have shown that baricitinib improves outcomes in…”
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Melatonin Uptake by Cells: An Answer to Its Relationship with Glucose? by Mayo, Juan C, Aguado, Arturo, Cernuda-Cernuda, Rafael, Álvarez-Artime, Alejandro, Cepas, Vanesa, Quirós-González, Isabel, Hevia, David, Sáinz, Rosa M

“…Melatonin, -acetyl-5-methoxytryptamine, is an indole mainly synthesized from tryptophan in the pineal gland and secreted exclusively during the night in all…”
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Chemical and physical properties and potential mechanisms: melatonin as a broad spectrum antioxidant and free radical scavenger by Tan, Dun-xian, Reiter, Russel J, Manchester, Lucien C, Yan, Mei-ting, El-Sawi, Mamdouh, Sainz, Rosa M, Mayo, Juan C, Kohen, Ron, Allegra, Mario, Hardeland, Rudiger

“…Melatonin was found to be a potent free radical scavenger in 1993. Since then over 800 publications have directly or indirectly confirmed this observation…”
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