Search Results - "Maynes, Jason T"

Rodent Models of Dilated Cardiomyopathy and Heart Failure for Translational Investigations and Therapeutic Discovery by Ponzoni, Matteo, Coles, John G, Maynes, Jason T

“…Even with modern therapy, patients with heart failure only have a 50% five-year survival rate. To improve the development of new therapeutic strategies,…”
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Influence of Surgical Procedures and General Anesthesia on Child Development Before Primary School Entry Among Matched Sibling Pairs by O'Leary, James D, Janus, Magdalena, Duku, Eric, Wijeysundera, Duminda N, To, Teresa, Li, Ping, Maynes, Jason T, Faraoni, David, Crawford, Mark W

“…Substantial preclinical evidence suggests that the developing brain is susceptible to injury from anesthetic drugs. Findings from clinical studies of the…”
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The effects of general anesthetics on mitochondrial structure and function in the developing brain by Hogarth, Kaley, Tarazi, Doorsa, Maynes, Jason T

“…The use of general anesthetics in modern clinical practice is commonly regarded as safe for healthy individuals, but exposures at the extreme ends of the age…”
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Impact of Opioids on Cellular Metabolism: Implications for Metabolic Pathways Involved in Cancer by Tarazi, Doorsa, Maynes, Jason T

“…Opioid utilization for pain management is prevalent among cancer patients. There is significant evidence describing the many effects of opioids on cancer…”
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Singular and short-term anesthesia exposure in the developing brain induces persistent neuronal changes consistent with chronic neurodegenerative disease by Hogarth, Kaley, Vanama, Ramesh Babu, Stratmann, Greg, Maynes, Jason T.

“…The potential adverse impact of inhalational anesthetics on the developing brain was highlighted by the addition of a medication warning by the U.S. Food and…”
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Effect of moist heat reprocessing of N95 respirators on SARS-CoV-2 inactivation and respirator function by Daeschler, Simeon C, Manson, Niclas, Joachim, Kariym, Chin, Alex W H, Chan, Katelyn, Chen, Paul Z, Tajdaran, Kiana, Mirmoeini, Kaveh, Zhang, Jennifer J, Maynes, Jason T, Zhang, Libo, Science, Michelle, Darbandi, Ali, Stephens, Derek, Gu, Frank, Poon, Leo L M, Borschel, Gregory H

“…Unprecedented demand for N95 respirators during the coronavirus disease 2019 (COVID-19) pandemic has led to a global shortage of these masks. We validated a…”
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iPSC-cardiomyocytes in the preclinical prediction of candidate pharmaceutical toxicity by Lee, Tim Y T, Coles, John G, Maynes, Jason T

“…Many challenges remain in the preclinical evaluation, adjudication, and prioritization of novel compounds in therapeutic discovery pipelines. These obstacles…”
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Understanding three standard study designs for randomized controlled trials by Niimi, Naoko, Yang, Alan, Sumie, Makoto, Hayes, Jason, Maynes, Jason T., Aoyama, Kazuyoshi

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Pulmonary vein stenosis and the pathophysiology of “upstream” pulmonary veins by Kato, Hideyuki, MD, Fu, Yaqin Yana, MD, MS, Zhu, Jiaquan, MD, PhD, Wang, Lixing, MD, PhD, Aafaqi, Shabana, MSc, Rahkonen, Otto, MD, Slorach, Cameron, RDCS, Traister, Alexandra, PhD, Leung, Chung Ho, BSc, Chiasson, David, MD, Mertens, Luc, MD, PhD, Benson, Lee, MD, Weisel, Richard D., MD, BA, Hinz, Boris, PhD, Maynes, Jason T., MD, PhD, Coles, John G., MD, Caldarone, Christopher A., MD

“…Background Surgical and catheter-based interventions on pulmonary veins are associated with pulmonary vein stenosis (PVS), which can progress diffusely through…”
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General medical publications during COVID-19 show increased dissemination despite lower validation by Gai, Nan, Aoyama, Kazuyoshi, Faraoni, David, Goldenberg, Neil M, Levin, David N, Maynes, Jason T, McVey, Mark J, Munshey, Farrukh, Siddiqui, Asad, Switzer, Timothy, Steinberg, Benjamin E

“…The COVID-19 pandemic has yielded an unprecedented quantity of new publications, contributing to an overwhelming quantity of information and leading to the…”
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Cancer proteome and metabolite changes linked to SHMT2 by Tong, Jiefei, Krieger, Jonathan R, Taylor, Paul, Bagshaw, Rick, Kang, Jae, Jeedigunta, Swathi, Wybenga-Groot, Leanne E, Zhang, Wen, Badr, Heba, Mirhadi, Shideh, Pham, Nhu-An, Coyaud, Étienne, Yu, Man, Li, Ming, Cabanero, Michael, Raught, Brian, Maynes, Jason T, Hawkins, Cynthia, Tsao, Ming Sound, Moran, Michael F

“…Serine hydroxymethyltransferase 2 (SHMT2) converts serine plus tetrahydrofolate (THF) into glycine plus methylene-THF and is upregulated at the protein level…”
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Multisystem inflammatory syndrome in children during the coronavirus disease pandemic of 2019: a review of clinical features and acute phase management by Shioji, Naohiro, Aoyama, Kazuyoshi, Englesakis, Marina, Annich, Gail, Maynes, Jason T.

“…The current coronavirus disease of 2019 (COVID-19) pandemic has presented unique health challenges in the pediatric population. Compared to adults, the most…”
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Microengineered platforms for characterizing the contractile function of in vitro cardiac models by Dou, Wenkun, Malhi, Manpreet, Zhao, Qili, Wang, Li, Huang, Zongjie, Law, Junhui, Liu, Na, Simmons, Craig A., Maynes, Jason T., Sun, Yu

“…Emerging heart-on-a-chip platforms are promising approaches to establish cardiac cell/tissue models in vitro for research on cardiac physiology, disease…”
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Vasculotide reduces pulmonary hyperpermeability in experimental pneumococcal pneumonia by Gutbier, Birgitt, Jiang, Xiaohui, Dietert, Kristina, Ehrler, Carolin, Lienau, Jasmin, Van Slyke, Paul, Kim, Harold, Hoang, Van C, Maynes, Jason T, Dumont, Daniel J, Gruber, Achim D, Weissmann, Norbert, Mitchell, Timothy J, Suttorp, Norbert, Witzenrath, Martin

“…Community-acquired pneumonia (CAP) is a significant cause of morbidity and mortality worldwide. Despite effective antimicrobial therapy, CAP can induce…”
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Biallelic Mutations in GNB3 Cause a Unique Form of Autosomal-Recessive Congenital Stationary Night Blindness by Vincent, Ajoy, Audo, Isabelle, Tavares, Erika, Maynes, Jason T., Tumber, Anupreet, Wright, Thomas, Li, Shuning, Michiels, Christelle, Banin, Eyal, Bocquet, Beatrice, De Baere, Elfride, Casteels, Ingele, Defoort-Dhellemmes, Sabine, Drumare, Isabelle, Friedburg, Christoph, Gottlob, Irene, Jacobson, Samuel G., Kellner, Ulrich, Koenekoop, Robert, Kohl, Susanne, Leroy, Bart P., Lorenz, Birgit, McLean, Rebecca, Meire, Francoise, Meunier, Isabelle, Munier, Francis, de Ravel, Thomy, Reiff, Charlotte M., Mohand-Saïd, Saddek, Sharon, Dror, Schorderet, Daniel, Schwartz, Sharon, Zanlonghi, Xavier, Condroyer, Christel, MacDonald, Heather, Verdet, Robert, Sahel, José-Alain, Hamel, Christian P., Zeitz, Christina, Héon, Elise

“…Congenital stationary night blindness (CSNB) is a heterogeneous group of non-progressive inherited retinal disorders with characteristic electroretinogram…”
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Inhalational Anesthetics Induce Neuronal Protein Aggregation and Affect ER Trafficking by Coghlan, Matthew, Richards, Elizabeth, Shaik, Sadiq, Rossi, Pablo, Vanama, Ramesh Babu, Ahmadi, Saumel, Petroz, Christelle, Crawford, Mark, Maynes, Jason T.

“…Anesthetic agents have been implicated in the causation of neurological and cognitive deficits after surgery, the exacerbation of chronic neurodegenerative…”
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Losartan ameliorates “upstream” pulmonary vein vasculopathy in a piglet model of pulmonary vein stenosis by Zhu, Jiaquan, MD, PhD, Ide, Haruki, MD, Fu, Yaqin Yana, MD, Teichert, Anouk-Martine, PhD, Kato, Hideyuki, MD, Weisel, Richard D., MD, Maynes, Jason T., MD, PhD, Coles, John G., MD, Caldarone, Christopher A., MD

“…Objectives Pulmonary vein stenosis (PVS) is a relentless disease with a poor prognosis. Although surgical repair can effectively treat “downstream” (near left…”
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The chemorepellent, SLIT2, bolsters innate immunity against Staphylococcus aureus by Bhosle, Vikrant K, Sun, Chunxiang, Patel, Sajedabanu, Ho, Tse Wing Winnie, Westman, Johannes, Ammendolia, Dustin A, Langari, Fatemeh Mirshafiei, Fine, Noah, Toepfner, Nicole, Li, Zhubing, Sharma, Manraj, Glogauer, Judah, Capurro, Mariana I, Jones, Nicola L, Maynes, Jason T, Lee, Warren L, Glogauer, Michael, Grinstein, Sergio, Robinson, Lisa A

“…Neutrophils are essential for host defense against Staphylococcus aureus ( S. aureus ). The neuro-repellent, SLIT2, potently inhibits neutrophil chemotaxis,…”
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Statin-mediated disruption of Rho GTPase prenylation and activity inhibits respiratory syncytial virus infection by Malhi, Manpreet, Norris, Michael J., Duan, Wenming, Moraes, Theo J., Maynes, Jason T.

“…Respiratory syncytial virus (RSV) is a leading cause of severe respiratory tract infections in children. To uncover new antiviral therapies, we developed a…”
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Unique challenges in pediatric anesthesia created by COVID-19 by Gai, Nan, Maynes, Jason T., Aoyama, Kazuyoshi

“…Coronavirus disease 2019 (COVID-19) has affected anesthetic care worldwide, including the provision of anesthesia for pediatric patients. Hospitals have…”
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