Search Results - "Mayne, Janice"

Metaproteomics reveals associations between microbiome and intestinal extracellular vesicle proteins in pediatric inflammatory bowel disease by Zhang, Xu, Deeke, Shelley A., Ning, Zhibin, Starr, Amanda E., Butcher, James, Li, Jennifer, Mayne, Janice, Cheng, Kai, Liao, Bo, Li, Leyuan, Singleton, Ruth, Mack, David, Stintzi, Alain, Figeys, Daniel

“…Alterations in gut microbiota have been implicated in the pathogenesis of inflammatory bowel disease (IBD), however factors that mediate the host–microbiota…”
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Catching a resurgence: Increase in SARS-CoV-2 viral RNA identified in wastewater 48 h before COVID-19 clinical tests and 96 h before hospitalizations by D'Aoust, Patrick M., Graber, Tyson E., Mercier, Elisabeth, Montpetit, Danika, Alexandrov, Ilya, Neault, Nafisa, Baig, Aiman Tariq, Mayne, Janice, Zhang, Xu, Alain, Tommy, Servos, Mark R., Srikanthan, Nivetha, MacKenzie, Malcolm, Figeys, Daniel, Manuel, Douglas, Jüni, Peter, MacKenzie, Alex E., Delatolla, Robert

“…Curtailing the Spring 2020 COVID-19 surge required sweeping and stringent interventions by governments across the world. Wastewater-based COVID-19 epidemiology…”
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An in vitro model maintaining taxon-specific functional activities of the gut microbiome by Li, Leyuan, Abou-Samra, Elias, Ning, Zhibin, Zhang, Xu, Mayne, Janice, Wang, Janet, Cheng, Kai, Walker, Krystal, Stintzi, Alain, Figeys, Daniel

“…In vitro gut microbiome models could provide timely and cost-efficient solutions to study microbiome responses to drugs. For this purpose, in vitro models that…”
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RapidAIM: a culture- and metaproteomics-based Rapid Assay of Individual Microbiome responses to drugs by Li, Leyuan, Ning, Zhibin, Zhang, Xu, Mayne, Janice, Cheng, Kai, Stintzi, Alain, Figeys, Daniel

“…Human-targeted drugs may exert off-target effects or can be repurposed to modulate the gut microbiota. However, our understanding of such effects is limited…”
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MetaLab: an automated pipeline for metaproteomic data analysis by Cheng, Kai, Ning, Zhibin, Zhang, Xu, Li, Leyuan, Liao, Bo, Mayne, Janice, Stintzi, Alain, Figeys, Daniel

“…Research involving microbial ecosystems has drawn increasing attention in recent years. Studying microbe-microbe, host-microbe, and environment-microbe…”
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Widespread protein lysine acetylation in gut microbiome and its alterations in patients with Crohn’s disease by Zhang, Xu, Ning, Zhibin, Mayne, Janice, Yang, Yidai, Deeke, Shelley A., Walker, Krystal, Farnsworth, Charles L., Stokes, Matthew P., Couture, Jean-François, Mack, David, Stintzi, Alain, Figeys, Daniel

“…Lysine acetylation (Kac), an abundant post-translational modification (PTM) in prokaryotes, regulates various microbial metabolic pathways. However, no studies…”
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The enigma of soluble LDLR: could inflammation be the key? by Mbikay, Majambu, Mayne, Janice, Chrétien, Michel

“…Soluble low-density lipoprotein receptor (sLDLR) is the circulating ectodomain of transmembrane LDLR. Its blood level strongly correlates with that of…”
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Revealing proteome-level functional redundancy in the human gut microbiome using ultra-deep metaproteomics by Li, Leyuan, Wang, Tong, Ning, Zhibin, Zhang, Xu, Butcher, James, Serrana, Joeselle M., Simopoulos, Caitlin M. A., Mayne, Janice, Stintzi, Alain, Mack, David R., Liu, Yang-Yu, Figeys, Daniel

“…Functional redundancy is a key ecosystem property representing the fact that different taxa contribute to an ecosystem in similar ways through the expression…”
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Evaluating live microbiota biobanking using an ex vivo microbiome assay and metaproteomics by Zhang, Xu, Walker, Krystal, Mayne, Janice, Li, Leyuan, Ning, Zhibin, Stintzi, Alain, Figeys, Daniel

“…Biobanking of live microbiota is becoming indispensable for mechanistic and clinical investigations of drug-microbiome interactions and fecal microbiota…”
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Berberine and its structural analogs have differing effects on functional profiles of individual gut microbiomes by Li, Leyuan, Chang, Lu, Zhang, Xu, Ning, Zhibin, Mayne, Janice, Ye, Yang, Stintzi, Alain, Liu, Jia, Figeys, Daniel

“…The understanding of the effects of compounds on the gut microbiome is limited. In particular, it is unclear whether structurally similar compounds would have…”
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PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities by Mbikay, Majambu, Sirois, Francine, Mayne, Janice, Wang, Gen-Sheng, Chen, Andrew, Dewpura, Thilina, Prat, Annik, Seidah, Nabil G., Chretien, Michel, Scott, Fraser W.

“…Proprotein convertase subtilisin/kexin type 9 (PCSK9), a liver-secreted plasma enzyme, restricts hepatic uptake of low-density lipoprotein (LDL) cholesterol by…”
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The Effect of PCSK9 Loss-of-Function Variants on the Postprandial Lipid and ApoB-Lipoprotein Response by Ooi, Teik Chye, Krysa, Jacqueline A, Chaker, Seham, Abujrad, Hussein, Mayne, Janice, Henry, Kathy, Cousins, Marion, Raymond, Angela, Favreau, Colette, Taljaard, Monica, Chrétien, Michel, Mbikay, Majambu, Proctor, Spencer D, Vine, Donna F

“…Abstract Context Proprotein convertase subtilisin kexin 9 (PCSK9) mediates degradation of the low-density lipoprotein receptor (LDLR), thereby increasing…”
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MetaPep: A core peptide database for faster human gut metaproteomics database searches by Sun, Zhongzhi, Ning, Zhibin, Cheng, Kai, Duan, Haonan, Wu, Qing, Mayne, Janice, Figeys, Daniel

“…Metaproteomics has increasingly been applied to study functional changes in the human gut microbiome. Peptide identification is an important step in…”
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A charge-suppressing strategy for probing protein methylation by Ning, Zhibin, Star, Alexandra Therese, Mierzwa, Anna, Lanouette, Sylvain, Mayne, Janice, Couture, Jean-Francois, Figeys, Daniel

“…Methylation of arginine and lysine (RK) residues play essential roles in epigenetics and the regulation of gene expression. However, research in this area is…”
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Early postnatal defects in neurogenesis in the 3xTg mouse model of Alzheimer’s disease by Liu, Yubing, Bilen, Maria, McNicoll, Marie-Michelle, Harris, Richard A., Fong, Bensun C., Iqbal, Mohamed Ariff, Paul, Smitha, Mayne, Janice, Walker, Krystal, Wang, Jing, Figeys, Daniel, Slack, Ruth S.

“…Alzheimer’s disease (AD) is a progressive neurodegenerative disorder leading to dementia. The hippocampus, which is one of the sites where neural stem cells…”
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Plasma PCSK9 levels are significantly modified by statins and fibrates in humans by Mayne, Janice, Dewpura, Thilina, Raymond, Angela, Cousins, Marion, Chaplin, Anna, Lahey, Karen A, Lahaye, Stephen A, Mbikay, Majambu, Ooi, Teik Chye, Chrétien, Michel

“…Proprotein convertase subtilisin kexin-like 9 (PCSK9) is a secreted glycoprotein that is transcriptionally regulated by cholesterol status. It modulates levels…”
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Comprehensive Assessment of Functional Effects of Commonly Used Sugar Substitute Sweeteners on Ex Vivo Human Gut Microbiome by Sun, Zhongzhi, Wang, Wenju, Li, Leyuan, Zhang, Xu, Ning, Zhibin, Mayne, Janice, Walker, Krystal, Stintzi, Alain, Figeys, Daniel

“…The composition and function of the human gut microbiome are often associated with health and disease status. Sugar substitute sweeteners are widely used food…”
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Examining the Effects of an Anti-Salmonella Bacteriophage Preparation, BAFASAL ® , on Ex-Vivo Human Gut Microbiome Composition and Function Using a Multi-Omics Approach by Mayne, Janice, Zhang, Xu, Butcher, James, Walker, Krystal, Ning, Zhibin, Wójcik, Ewelina, Dastych, Jarosław, Stintzi, Alain, Figeys, Daniel

“…infections (salmonellosis) pose serious health risks to humans, usually via food-chain contamination. This foodborne pathogen causes major food losses and…”
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Aging Disrupts the Circadian Patterns of Protein Expression in the Murine Hippocampus by Adler, Paula, Chiang, Cheng-Kang, Mayne, Janice, Ning, Zhibin, Zhang, Xu, Xu, Bo, Cheng, Hai-Ying Mary, Figeys, Daniel

“…Aging is associated with cognitive decline and dysregulation of the circadian system, which modulates hippocampal-dependent memory as well as biological…”
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The proteomic landscape of the suprachiasmatic nucleus clock reveals large-scale coordination of key biological processes by Chiang, Cheng-Kang, Mehta, Neel, Patel, Abhilasha, Zhang, Peng, Ning, Zhibin, Mayne, Janice, Sun, Warren Y L, Cheng, Hai-Ying M, Figeys, Daniel

“…The suprachiasmatic nucleus (SCN) acts as the central clock to coordinate circadian oscillations in mammalian behavior, physiology and gene expression. Despite…”
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