Search Results - "Mayhew, Nicholas J."

Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators by Rynearson, Kevin D., Buckle, Ronald N., Herr, R. Jason, Mayhew, Nicholas J., Chen, Xinchao, Paquette, William D., Sakwa, Samuel A., Yang, Jinhai, Barnes, Keith D., Nguyen, Phuong, Mobley, William C., Johnson, Graham, Lin, Juinn H., Tanzi, Rudolph E., Wagner, Steven L.

“…[Display omitted] The evolution of gamma-secretase modulators (GSMs) through the introduction of novel heterocycles with the goal of aligning activity for…”
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Design and synthesis of aminothiazole modulators of the gamma-secretase enzyme by Rynearson, Kevin D., Buckle, Ronald N., Barnes, Keith D., Herr, R. Jason, Mayhew, Nicholas J., Paquette, William D., Sakwa, Samuel A., Nguyen, Phuong D., Johnson, Graham, Tanzi, Rudolph E., Wagner, Steven L.

“…[Display omitted] The design and construction of a series of novel aminothiazole-derived γ-secretase modulators is described. The incorporation of heterocyclic…”
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Lactam Coupling as a Versatile Route to Indoprofen Analogs by Barnes, Keith D., Chen, Ping, Chang, Yingyan, Lewis, Robert M., Manley, Christopher M., Mayhew, Nicholas J., Steffke, Stephen H., Wang, Guixing, Wang, Yi, Yang, Yuh-Lin A., Lippert III, John W.

“…A convergent synthesis of indoprofen via a Buchwald coupling approach is reported. Using this methodology, indoprofen and a set of analogs of indoprofen were…”
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