Designing Temperature-Responsive Biocompatible Copolymers and Hydrogels Based on 2-Hydroxyethyl(meth)acrylates

Free-radical copolymerization of 2-hydroxyethyl methacrylate with 2-hydroxyethyl acrylate can be successively utilized for the synthesis of water-soluble polymers and hydrogels with excellent physicochemical properties, thus showing promise for pharmaceutical and biomedical applications. In the work...

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Bibliographic Details
Published in:	Biomacromolecules Vol. 9; no. 12; pp. 3353 - 3361
Main Authors:	Khutoryanskaya, Olga V, Mayeva, Zarina A, Mun, Grigoriy A, Khutoryanskiy, Vitaliy V
Format:	Journal Article
Language:	English
Published:	Washington, DC American Chemical Society 08-12-2008
Subjects:	Acrylates - chemistry Animals Applied sciences Biocompatible Materials - adverse effects Biocompatible Materials - chemical synthesis Biocompatible Materials - chemistry Biocompatible Materials - pharmacology Biological and medical sciences Biomechanical Phenomena Chemistry, Pharmaceutical Copolymerization Drug Carriers - adverse effects Drug Carriers - chemical synthesis Drug Carriers - chemistry Elasticity Exact sciences and technology Gastropoda - drug effects General pharmacology Hydrogels - adverse effects Hydrogels - chemical synthesis Hydrogels - chemistry Hydrogels - pharmacology Materials Testing Medical sciences Methacrylates - chemistry Molecular Weight Mucous Membrane - drug effects Organic polymers Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physicochemistry of polymers Porosity Preparation, kinetics, thermodynamics, mechanism and catalysts Solubility Temperature Water - chemistry Biological properties Linear copolymer Property composition relationship Mucosa Drug carrier Gastropoda Limacidae Colloidal gel Cloud point Pulmonata Biocompatibility Irritation Elastic modulus Swelling Control release polymer Mechanical properties Hydroxyethyl methacrylate copolymer Experimental study In vivo Limax flavus Animal Morphology Preparation Kinetics Aqueous solution Invertebrata Mollusca Hydroxyethyl acrylate copolymer Radical copolymerization
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Summary:	Free-radical copolymerization of 2-hydroxyethyl methacrylate with 2-hydroxyethyl acrylate can be successively utilized for the synthesis of water-soluble polymers and hydrogels with excellent physicochemical properties, thus showing promise for pharmaceutical and biomedical applications. In the work presented it has been demonstrated that water-soluble copolymers based on 2-hydroxyethyl methacrylate and 2-hydroxyethyl acrylate exhibit lower critical solution temperature in aqueous solutions, whereas the corresponding high molecular weight homopolymers do not have this unique property. The temperature-induced transitions observed upon heating the aqueous solutions of these copolymers proceed via liquid−liquid phase separation. The hydrogels were also synthesized by copolymerizing 2-hydroxyethyl methacrylate and 2-hydroxyethyl acrylate in the absence of a bifunctional cross-linker. The cross-linking of these copolymers during copolymerization is believed to be due to the presence of bifunctional admixtures or transesterification reactions. Transparency, swelling behavior, mechanical properties, and porosity of the hydrogels are dependent upon the monomer ratio in the copolymers. Hydrogel samples containing more 2-hydroxyethyl methacrylate are less transparent, have lower swelling capacity, higher elastic moduli, and pores of smaller size. The assessment of the biocompatibility of the copolymers using the slug mucosal irritation test revealed that they are also less irritant than poly(acrylic acid).
ISSN:	1525-7797 1526-4602
DOI:	10.1021/bm8006242