Search Results - "Mayer, R. John"

Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets by Brownell, James E, Bedford, Lynn, Lowe, James, Dick, Lawrence R, Mayer, R. John

“…Key Points Ubiquitin is a highly conserved 76 amino-acid protein that covalently attaches to protein substrates targeted for degradation by the 26S proteasome…”
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Assembly, structure, and function of the 26S proteasome by Bedford, Lynn, Paine, Simon, Sheppard, Paul W, Mayer, R. John, Roelofs, Jeroen

“…The 26S proteasome is a large multiprotein complex involved in the regulated degradation of ubiquitinated proteins in the cell. The 26S proteasome has been…”
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Proteasome Dysfunction Activates Autophagy and the Keap1-Nrf2 Pathway by Kageyama, Shun, Sou, Yu-shin, Uemura, Takefumi, Kametaka, Satoshi, Saito, Tetsuya, Ishimura, Ryosuke, Kouno, Tsuguka, Bedford, Lynn, Mayer, R. John, Lee, Myung-Shik, Yamamoto, Masayuki, Waguri, Satoshi, Tanaka, Keiji, Komatsu, Masaaki

“…The ubiquitin-proteasome system and autophagy are crucially important for proteostasis in cells. These pathways are interdependent, and dysfunction in either…”
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Depletion of 26S Proteasomes in Mouse Brain Neurons Causes Neurodegeneration and Lewy-Like Inclusions Resembling Human Pale Bodies by Bedford, Lynn, Hay, David, Devoy, Anny, Paine, Simon, Powe, Des G, Seth, Rashmi, Gray, Trevor, Topham, Ian, Fone, Kevin, Rezvani, Nooshin, Mee, Maureen, Soane, Tim, Layfield, Robert, Sheppard, Paul W, Ebendal, Ted, Usoskin, Dmitry, Lowe, James, Mayer, R. John

“…Ubiquitin-positive intraneuronal inclusions are a consistent feature of the major human neurodegenerative diseases, suggesting that dysfunction of the…”
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Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway by Ugun-Klusek, Aslihan, Tatham, Michael H, Elkharaz, Jamal, Constantin-Teodosiu, Dumitru, Lawler, Karen, Mohamed, Hala, Paine, Simon M L, Anderson, Glen, John Mayer, R, Lowe, James, Ellen Billett, E, Bedford, Lynn

“…The ubiquitin–proteasome system (UPS) and macroautophagy (autophagy) are central to normal proteostasis and interdependent in that autophagy is known to…”
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The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53 by Higashitsuji, Hiroaki, Higashitsuji, Hisako, Itoh, Katsuhiko, Sakurai, Toshiharu, Nagao, Toshikazu, Sumitomo, Haruhiko, Masuda, Tomoko, Dawson, Simon, Shimada, Yutaka, Mayer, R. John, Fujita, Jun

“…Gankyrin is an ankyrin repeat oncoprotein commonly overexpressed in hepatocellular carcinomas. Gankyrin interacts with the S6 proteasomal ATPase and…”
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Pale body-like inclusion formation and neurodegeneration following depletion of 26S proteasomes in mouse brain neurones are independent of α-synuclein by Paine, Simon M L, Anderson, Glenn, Bedford, Karen, Lawler, Karen, Mayer, R John, Lowe, James, Bedford, Lynn

“…Parkinson's disease (PD) is characterized by the progressive degeneration of substantia nigra pars compacta (SNpc) dopaminergic neurones and the formation of…”
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Gankyrin Is an Ankyrin-repeat Oncoprotein That Interacts with CDK4 Kinase and the S6 ATPase of the 26 S Proteasome by Dawson, Simon, Apcher, Sebastien, Mee, Maureen, Mayer, R. John, Higashitsuji, Hiroaki, Baker, Rohan, Uhle, Stefan, Dubiel, Wolfgang, Fujita, Jun

“…A yeast two-hybrid screen with the human S6 (TBP7, RPT3) ATPase of the 26 S proteasome has identified gankyrin, a liver oncoprotein, as an interacting protein…”
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Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas by Fujita, Jun, Higashitsuji, Hiroaki, Itoh, Katsuhiko, Nagao, Toshikazu, Dawson, Simon, Nonoguchi, Kohsuke, Kido, Tsuneo, Mayer, R. John, Arii, Shigeki

“…Hepatocellular carcinoma (HCC) is one of the most common cancers in Asia and Africa, where hepatitis virus infection and exposure to specific liver carcinogens…”
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The Calcineurin-TFEB-p62 Pathway Mediates the Activation of Cardiac Macroautophagy by Proteasomal Malfunction by Pan, Bo, Li, Jie, Parajuli, Nirmal, Tian, Zongwen, Wu, Penglong, Lewno, Megan T., Zou, Jianqiu, Wang, Wenjuan, Bedford, Lynn, Mayer, R. John, Fang, Jing, Liu, Jinbao, Cui, Taixing, Su, Huabo, Wang, Xuejun

“…The ubiquitin-proteasome system (UPS) and the autophagic-lysosomal pathway are pivotal to proteostasis. Targeting these pathways is emerging as an attractive…”
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Can neurodegeneration be separated from neuropathological hallmarks of chronic idiopathic human neurodegenerative disease? A perspective from modelling by Paine, Simon, Lowe, James, Bedford, Lynn, Mayer, R John

“…Chronic neurodegenerative disease is characterized by extensive regional loss of neurons in the brain and neuropathological hallmarks in surviving neurones…”
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Heterozygosity for the proteasomal Psmc1 ATPase is insufficient to cause neuropathology in mouse brain, but causes cell cycle defects in mouse embryonic fibroblasts by Rezvani, Nooshin, Elkharaz, Jamal, Lawler, Karen, Mee, Maureen, Mayer, R. John, Bedford, Lynn

“…► Proteasomal Psmc1 ATPase heterozygosity does not cause neuropathology in mouse brain. ► Age-related intraneuronal K48-specific polyubiquitin granular…”
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The Oncoprotein Gankyrin Negatively Regulates Both p53 and RB by Enhancing Proteasomal Degradation by Higashitsuji, Hiroaki, Liu, Yu, Mayer, R. John, Fujita, Jun

“…Ubiquitin-dependent proteolysis mediates selective destruction of various cell cycle regulators, transcription factors and tumor suppressors. Gankyrin, a seven…”
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MAGE-A4 Interacts with the Liver Oncoprotein Gankyrin and Suppresses Its Tumorigenic Activity by Nagao, Toshikazu, Higashitsuji, Hiroaki, Nonoguchi, Kohsuke, Sakurai, Toshiharu, Dawson, Simon, Mayer, R John, Itoh, Katsuhiko, Fujita, Jun

“…Hepatocellular carcinoma ranks among the most common malignancies in Southeast Asia and South Africa. Although there are many modalities of treatment, the…”
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Ubiquitin and ubiquitin-like proteins as multifunctional signals by Mayer, R. John, Welchman, Rebecca L, Gordon, Colin

“…Protein ubiquitylation is a recognized signal for protein degradation. However, it is increasingly realized that ubiquitin conjugation to proteins can be used…”
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The Crystal Structure of Gankyrin, an Oncoprotein Found in Complexes with Cyclin-dependent Kinase 4, a 19 S Proteasomal ATPase Regulator, and the Tumor Suppressors Rb and p53 by Krzywda, Szymon, Brzozowski, Andrzej M., Higashitsuji, Hiroaki, Fujita, Jun, Welchman, Rebecca, Dawson, Simon, Mayer, R.John, Wilkinson, Anthony J.

“…Gankyrin is a 25-kDa hepatocellular carcinoma-associated protein that mediates protein-protein interactions in cell cycle control and protein degradation. It…”
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The UPS and autophagy in chronic neurodegenerative disease: Six of one and half a dozen of the other-Or not? by Bedford, Lynn, Paine, Simon, Rezvani, Nooshin, Mee, Maureen, Lowe, James, Mayer, R. John

“…In the past twenty years, evidence has accumulated to show that ubiquitinated proteins are a consistent feature of the intraneuronal protein aggregates…”
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The meteoric rise of regulated intracellular proteolysis by John Mayer, R

“…It is often the case in biology that research into breaking things down lags behind research into synthesizing them, and this is certainly true for…”
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Subcellular distribution of the TSC2 gene product tuberin in human airway smooth muscle cells is driven by multiple localization sequences and is cell-cycle dependent by Clements, Debbie, Mayer, R John, Johnson, Simon R

“…The products of the tuberous sclerosis complex (TSC) genes, hamartin and tuberin (TSC1 and 2), form a heteromer, which represses the kinase mammalian target of…”
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AAA proteins and the life process by Förster, Andreas, Freemont, Paul S, Mayer, R John

“…AAAs (ATPases associated with various cellular activities) form a large group of P-loop NTPases, themselves the most abundant class of protein in all…”
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