Search Results - "Mayer, Hannah"

A stochastic model for immunotherapy of cancer by Baar, Martina, Coquille, Loren, Mayer, Hannah, Hölzel, Michael, Rogava, Meri, Tüting, Thomas, Bovier, Anton

“…We propose an extension of a standard stochastic individual-based model in population dynamics which broadens the range of biological applications. Our primary…”
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Multiscale classification of heart failure phenotypes by unsupervised clustering of unstructured electronic medical record data by Nagamine, Tasha, Gillette, Brian, Pakhomov, Alexey, Kahoun, John, Mayer, Hannah, Burghaus, Rolf, Lippert, Jörg, Saxena, Mayur

“…As a leading cause of death and morbidity, heart failure (HF) is responsible for a large portion of healthcare and disability costs worldwide. Current…”
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Computational Simulation of Virtual Patients Reduces Dataset Bias and Improves Machine Learning-Based Detection of ARDS from Noisy Heterogeneous ICU Datasets by Sharafutdinov, Konstantin, Fritsch, Sebastian Johannes, Iravani, Mina, Ghalati, Pejman Farhadi, Saffaran, Sina, Bates, Declan G., Hardman, Jonathan G., Polzin, Richard, Mayer, Hannah, Marx, Gernot, Bickenbach, Johannes, Schuppert, Andreas

“…Goal: Machine learning (ML) technologies that leverage large-scale patient data are promising tools predicting disease evolution in individual patients…”
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Population pharmacokinetic analysis of rivaroxaban in children and comparison to prospective physiologically‐based pharmacokinetic predictions by Willmann, Stefan, Coboeken, Katrin, Zhang, Yang, Mayer, Hannah, Ince, Ibrahim, Mesic, Emir, Thelen, Kirstin, Kubitza, Dagmar, Lensing, Anthonie W. A., Yang, Haitao, Zhu, Peijuan, Mück, Wolfgang, Drenth, Henk‐Jan, Lippert, Jörg

“…Rivaroxaban has been investigated in the EINSTEIN‐Jr program for the treatment of acute venous thromboembolism (VTE) in children aged 0 to 18 years and in the…”
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Algorithmic surveillance of ICU patients with acute respiratory distress syndrome (ASIC): protocol for a multicentre stepped-wedge cluster randomised quality improvement strategy by Marx, Gernot, Bickenbach, Johannes, Fritsch, Sebastian Johannes, Kunze, Julian Benedict, Maassen, Oliver, Deffge, Saskia, Kistermann, Jennifer, Haferkamp, Silke, Lutz, Irina, Voellm, Nora Kristiana, Lowitsch, Volker, Polzin, Richard, Sharafutdinov, Konstantin, Mayer, Hannah, Kuepfer, Lars, Burghaus, Rolf, Schmitt, Walter, Lippert, Joerg, Riedel, Morris, Barakat, Chadi, Stollenwerk, André, Fonck, Simon, Putensen, Christian, Zenker, Sven, Erdfelder, Felix, Grigutsch, Daniel, Kram, Rainer, Beyer, Susanne, Kampe, Knut, Gewehr, Jan Erik, Salman, Friederike, Juers, Patrick, Kluge, Stefan, Tiller, Daniel, Wisotzki, Emilia, Gross, Sebastian, Homeister, Lorenz, Bloos, Frank, Scherag, André, Ammon, Danny, Mueller, Susanne, Palm, Julia, Simon, Philipp, Jahn, Nora, Loeffler, Markus, Wendt, Thomas, Schuerholz, Tobias, Groeber, Petra, Schuppert, Andreas

“…IntroductionThe acute respiratory distress syndrome (ARDS) is a highly relevant entity in critical care with mortality rates of 40%. Despite extensive…”
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Application of convex hull analysis for the evaluation of data heterogeneity between patient populations of different origin and implications of hospital bias in downstream machine-learning-based data processing: A comparison of 4 critical-care patient datasets by Sharafutdinov, Konstantin, Bhat, Jayesh S., Fritsch, Sebastian Johannes, Nikulina, Kateryna, E. Samadi, Moein, Polzin, Richard, Mayer, Hannah, Marx, Gernot, Bickenbach, Johannes, Schuppert, Andreas

“…Machine learning (ML) models are developed on a learning dataset covering only a small part of the data of interest. If model predictions are accurate for the…”
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Mammalian display to secretion switchable libraries for antibody preselection and high throughput functional screening by Gaa, Ramona, Mayer, Hannah Melina, Noack, Daniela, Kumari, Kavita, Guenther, Ralf, Tsai, Shang-Pu, Ji, Qingyong, Doerner, Achim

“…Recently, there has been a co-evolution of mammalian libraries and diverse microfluidic approaches for therapeutic antibody hit discovery. Mammalian libraries…”
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Defining diurnal fluctuations in mouse choroid plexus and CSF at high molecular, spatial, and temporal resolution by Fame, Ryann M., Kalugin, Peter N., Petrova, Boryana, Xu, Huixin, Soden, Paul A., Shipley, Frederick B., Dani, Neil, Grant, Bradford, Pragana, Aja, Head, Joshua P., Gupta, Suhasini, Shannon, Morgan L., Chifamba, Fortunate F., Hawks-Mayer, Hannah, Vernon, Amanda, Gao, Fan, Zhang, Yong, Holtzman, Michael J., Heiman, Myriam, Andermann, Mark L., Kanarek, Naama, Lipton, Jonathan O., Lehtinen, Maria K.

“…Transmission and secretion of signals via the choroid plexus (ChP) brain barrier can modulate brain states via regulation of cerebrospinal fluid (CSF)…”
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An integrated mammalian library approach for optimization and enhanced microfluidics-assisted antibody hit discovery by Gaa, Ramona, Kumari, Kavita, Mayer, Hannah Melina, Yanakieva, Desislava, Tsai, Shang-Pu, Joshi, Saurabh, Guenther, Ralf, Doerner, Achim

“…Recent years have seen the development of a variety of mammalian library approaches for display and secretion mode. Advantages include library approaches for…”
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The absence of mrp4 has no effect on the recruitment of neutrophils and eosinophils into the lung after LPS, cigarette smoke or allergen challenge by Schymeinsky, Jürgen, Mayer, Hannah, Tomsic, Christopher, Tilp, Cornelia, Schuetz, John D, Cui, Yunhai, Wollin, Lutz, Gantner, Florian, Erb, Klaus J

“…The multidrug resistance protein 4 (Mrp4) is an ATP-binding cassette transporter that is capable of exporting the second messenger cAMP from cells, a process…”
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Stochastic modelling of T-cell activation by Mayer, Hannah, Bovier, Anton

“…We investigate a specific part of the human immune system, namely the activation of T-cells, using stochastic tools, especially sharp large deviation results…”
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Mechanisms of sleep and circadian ontogeny through the lens of neurodevelopmental disorders by Barone, Ilaria, Hawks-Mayer, Hannah, Lipton, Jonathan O.

“…•Sleep and circadian disruption are highly regulated during development.•The ontogeny of sleep architecture and physiology correlates with major maturational…”
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Selective survival of Escherichia coli phylotypes in freshwater beach sand by Rumball, Natalie A, Mayer, HannahRose C, McLellan, Sandra L

“…is used as an indicator of fecal pollution at beaches despite evidence of long-term survival in sand. This work investigated the basis for survival of through…”
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Deletion of Neuronal GLT-1 in Mice Reveals Its Role in Synaptic Glutamate Homeostasis and Mitochondrial Function by McNair, Laura F, Andersen, Jens V, Aldana, Blanca I, Hohnholt, Michaela C, Nissen, Jakob D, Sun, Yan, Fischer, Kathryn D, Sonnewald, Ursula, Nyberg, Nils, Webster, Sophie C, Kapur, Kush, Rimmele, Theresa S, Barone, Ilaria, Hawks-Mayer, Hannah, Lipton, Jonathan O, Hodgson, Nathaniel W, Hensch, Takao K, Aoki, Chiye J, Rosenberg, Paul A, Waagepetersen, Helle S

“…The glutamate transporter GLT-1 is highly expressed in astrocytes but also in neurons, primarily in axon terminals. We generated a conditional neuronal GLT-1…”
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Computer Gaming Disorder and ADHD in Young Children—a Population-Based Study by Paulus, Frank W., Sinzig, Jenny, Mayer, Hannah, Weber, Monika, von Gontard, Alexander

“…As new mass media has become a common activity already in nursery school, this study aimed to analyze computer game playing, addiction, and ADHD in a…”
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Engineering advanced neural tissue constructs to mitigate acute cerebral inflammation after brain transplantation in rats by Liaudanskaya, Volha, Jgamadze, Dennis, Berk, Alexander N., Bischoff, David J., Gu, Ben J., Hawks-Mayer, Hannah, Whalen, Michael J., Chen, H. Isaac, Kaplan, David L.

“…Stroke, traumatic brain injuries, and other similar conditions often lead to significant loss of functional brain tissue and associated disruption of neuronal…”
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Early prediction of decompensation (EPOD) score: Non‐invasive determination of cirrhosis decompensation risk by Schneider, Annika R. P., Schneider, Carolin V., Schneider, Kai Markus, Baier, Vanessa, Schaper, Steffen, Diedrich, Christian, Coboeken, Katrin, Mayer, Hannah, Gu, Wenyi, Trebicka, Jonel, Blank, Lars M., Burghaus, Rolf, Lippert, Joerg, Rader, Daniel J., Thaiss, Christoph A., Schlender, Jan‐Frederik, Trautwein, Christian, Kuepfer, Lars

“…Background & Aims Decompensation is a hallmark of disease progression in cirrhotic patients. Early detection of a phase transition from compensated cirrhosis…”
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Algorithmic surveillance of I CU patients with acute respiratory distress syndrome (ASIC): protocol for a multicentre stepped-wedge cluster randomised quality improvement strategy by Marx, Gernot, Bickenbach, Johannes, Fritsch, Sebastian Johannes, Kunze, Julian Benedict, Maassen, Oliver, Deffge, Saskia, Kistermann, Jennifer, Haferkamp, Silke, Lutz, Irina, Voellm, Nora Kristiana, Lowitsch, Volker, Polzin, Richard, Sharafutdinov, Konstantin, Mayer, Hannah, Kuepfer, Lars, Burghaus, Rolf, Schmitt, Walter, Lippert, Joerg, Riedel, Morris, Barakat, Chadi, Stollenwerk, André, Fonck, Simon, Putensen, Christian, Zenker, Sven, Erdfelder, Felix, Grigutsch, Daniel, Kram, Rainer, Beyer, Susanne, Kampe, Knut, Gewehr, Jan Erik, Salman, Friederike, Juers, Patrick, Kluge, Stefan, Tiller, Daniel, Wisotzki, Emilia, Gross, Sebastian, Homeister, Lorenz, Bloos, Frank, Scherag, André, Ammon, Danny, Mueller, Susanne, Palm, Julia, Simon, Philipp, Jahn, Nora, Loeffler, Markus, Wendt, Thomas, Schuerholz, Tobias, Groeber, Petra, Schuppert, Andreas

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Synaptic BMAL1 phosphorylation controls circadian hippocampal plasticity by Barone, Ilaria, Gilette, Nicole M, Hawks-Mayer, Hannah, Handy, Jonathan, Zhang, Kevin J, Chifamba, Fortunate F, Mostafa, Engie, Johnson-Venkatesh, Erin M, Sun, Yan, Gibson, Jennifer M, Rotenberg, Alexander, Umemori, Hisashi, Tsai, Peter T, Lipton, Jonathan O

“…The time of day strongly influences adaptive behaviors like long-term memory, but the correlating synaptic and molecular mechanisms remain unclear. The…”
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Comment on model-based meta-analysis to evaluate optimal doses of direct oral factor Xa inhibitors in atrial fibrillation patients by Willmann, Stefan, Zhang, Liping, Mayer, Hannah, Siegmund, Hans-Ulrich, Tanigawa, Takahiko, Kaneko, Masato, Peters, Gary, Weitz, Jeffrey I., Berkowitz, Scott D., Burghaus, Rolf

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