Search Results - "Mayer, Brian P"

Evaluation of polyanionic cyclodextrins as high affinity binding scaffolds for fentanyl by Mayer, Brian P., Kennedy, Daniel J., Lau, Edmond Y., Valdez, Carlos A.

“…Cyclodextrins (CDs) have been previously shown to display modest equilibrium binding affinities ( K a  ~ 100–200 M -1 ) for the synthetic opioid analgesic…”
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An efficient, optimized synthesis of fentanyl and related analogs by Valdez, Carlos A, Leif, Roald N, Mayer, Brian P

“…The alternate and optimized syntheses of the parent opioid fentanyl and its analogs are described. The routes presented exhibit high-yielding transformations…”
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Evaluation of 6-OxP-CD, an Oxime-based cyclodextrin as a viable medical countermeasure against nerve agent poisoning: Experimental and molecular dynamic simulation studies on its inclusion complexes with cyclosarin, soman and VX by Lau, Edmond Y, Enright, Heather A, Lao, Victoria, Malfatti, Michael A, Mayer, Brian P, Williams, Audrey M, Valdez, Carlos A

“…The ability of the cyclodextrin-oxime construct 6-OxP-CD to bind and degrade the nerve agents Cyclosarin (GF), Soman (GD) and S-[2-[Di(propan-2-yl)amino]ethyl]…”
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A Methodology for the Indirect Determination and Spatial Resolution of Shear Modulus of PDMS−Silica Elastomers by Mayer, Brian P, Reimer, Jeffrey A, Maxwell, Robert S

“…A methodology is described that allows for the spatial resolution of shear modulus in silica-filled PDMS elastomers via 1H relaxation measurements and…”
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Countermeasures for Preventing and Treating Opioid Overdose by France, Charles P., Ahern, Gerard P., Averick, Saadyah, Disney, Alex, Enright, Heather A., Esmaeli‐Azad, Babak, Federico, Arianna, Gerak, Lisa R., Husbands, Stephen M., Kolber, Benedict, Lau, Edmond Y., Lao, Victoria, Maguire, David R., Malfatti, Michael A., Martinez, Girardo, Mayer, Brian P., Pravetoni, Marco, Sahibzada, Niaz, Skolnick, Phil, Snyder, Evan Y., Tomycz, Nestor, Valdez, Carlos A., Zapf, Jim

“…The only medication available currently to prevent and treat opioid overdose (naloxone) was approved by the US Food and Drug Administration (FDA) nearly…”
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Part 3: Solid phase extraction of Russian VX and its chemical attribution signatures in food matrices and their detection by GC-MS and LC-MS by Williams, Audrey M., Vu, Alexander K., Mayer, Brian P., Hok, Saphon, Valdez, Carlos A., Alcaraz, Armando

“…Chemical attribution signatures indicative of O-isobutyl S-(2-diethylaminoethyl) methylphosphonothioate (Russian VX) synthetic routes were investigated in…”
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Chemical Attribution of Fentanyl Using Multivariate Statistical Analysis of Orthogonal Mass Spectral Data by Mayer, Brian P, DeHope, Alan J, Mew, Daniel A, Spackman, Paul E, Williams, Audrey M

“…Attribution of the origin of an illicit drug relies on identification of compounds indicative of its clandestine production and is a key component of many…”
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Toward Machine Learning-Driven Mass Spectrometric Identification of Trichothecenes in the Absence of Standard Reference Materials by Mayer, Brian P., Dreyer, Mark L., Prieto Conaway, Maria C., Valdez, Carlos A., Corzett, Todd, Leif, Roald, Williams, Audrey M.

“…While a significant body of work exists on the detection of commonly known trichothecene toxins, biological, environmental, and other transformational…”
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Statistical analysis of the chemical attribution signatures of 3-methylfentanyl and its methods of production by Mayer, Brian P., Valdez, Carlos A., DeHope, Alan J., Spackman, Paul E., Williams, Audrey M.

“…Chemical attribution of the origin of an illegal drug is a key component of forensic efforts aimed at combating illicit and clandestine manufacture of drugs…”
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Solution-State Structure and Affinities of Cyclodextrin:Fentanyl Complexes by Nuclear Magnetic Resonance Spectroscopy and Molecular Dynamics Simulation by Mayer, Brian P, Kennedy, Daniel J, Lau, Edmond Y, Valdez, Carlos A

“…Cyclodextrins (CDs) are investigated for their ability to form inclusion complexes with the analgesic fentanyl and three similar molecules: acetylfentanyl,…”
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Multi-Method Characterization of Compression Set in Fluorosilicone O-Rings by Harley, Stephen J., Mayer, Brian P., Glascoe, Elizabeth A., Maxwell, Robert S., Von White, Gregory, Bernstein, Robert

“…Fluorosilicone o-rings with varying levels of compression set were investigated with a variety of methods. Low field NMR experiments were able to elucidate if…”
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Solid state NMR investigation of γ-irradiated composite siloxanes: Probing the silica/polysiloxane interface by Mayer, Brian P., Chinn, Sarah C., Maxwell, Robert S., Reimer, Jeffrey A.

“…We employ silicon-proton (29Si{1H}) cross polarization magic-angle spinning (CP-MAS) to probe directly the interface of a silica-filled polysiloxane elastomer…”
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Linking Network Microstructure to Macroscopic Properties of Siloxane Elastomers Using Combined Nuclear Magnetic Resonance and Mesoscale Computational Modeling by Mayer, Brian P, Lewicki, James P, Weisgraber, Todd H, Small, Ward, Chinn, Sarah C, Maxwell, Robert S

“…It is well established that many fundamental properties of polymer materials are directly governed by chain dynamics, and both experimental and computational…”
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Thermal Degradation Behavior and Product Speciation in Model Poly(dimethylsiloxane) Networks by Lewicki, James P., Mayer, Brian P., Alviso, Cynthia T., Maxwell, Robert S.

“…The thermal degradation behavior of a series of well defined poly(dimethylsiloxane) (PDMS) model networks has been studied using a combination analytical…”
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Nuclear magnetic resonance and principal component analysis for investigating the degradation of poly[chlorotrifluoroethylene-co-(vinylidene fluoride)] by ionizing radiation by Mayer, Brian P., Lewicki, James P., Chinn, Sarah C., Overturf, George E., Maxwell, Robert S.

“…Reported here is the application of multivariate statistical analysis to nuclear magnetic resonance (NMR) data for the understanding of irradiative degradation…”
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NMR spectroscopic investigation of inclusion complexes between cyclodextrins and the neurotoxin tetramethylenedisulfotetramine by Mayer, Brian P., Albo, Rebecca L. F., Hok, Saphon, Valdez, Carlos A.

“…The binding stoichiometry, strength and structure of inclusion complexes formed between the neurotoxin tetramethylenedisulfotetramine (TETS) and both native…”
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Modeling (1)H NMR transverse magnetization decay in polysiloxane-silica composites by Mayer, Brian P, Chinn, Sarah C, Reimer, Robert S. Maxwell andJeffrey A.

“…Nuclear magnetic resonance (NMR) spectroscopy has been used effectively in the analysis of elastomeric, soft materials and has been proven to be both sensitive…”
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The Influence of Polyhedral Oligomeric Silsequioxanes on Domain Microstructure in Polyurethane Elastomers by Lewicki, James P., Harley, Stephen J., Loui, Albert, Pielichowski, Krzysztof, Mayer, Brian P., Janowski, Bartlomiej, Maxwell, Robert S.

“…The influence of polyhedral oligomeric silsequioxanes (POSS) as covalently bound hybrid physical property modifiers on the segmental dynamics and morphology of…”
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Modeling 1H NMR transverse magnetization decay in polysiloxane-silica composites by Mayer, Brian P., Chinn, Sarah C., Maxwell, Robert S., Reimer, Jeffrey A.

“…Nuclear magnetic resonance (NMR) spectroscopy has been used effectively in the analysis of elastomeric, soft materials and has been proven to be both sensitive…”
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Kinetics and speciation of paraoxon hydrolysis by zinc(II)–azamacrocyclic catalysts by Kennedy, Daniel J., Mayer, Brian P., Baker, Sarah E., Valdez, Carlos A.

“…The pesticide diethyl paraoxon (O,O-diethyl O-(4-nitrophenyl) phosphate) is catalytically hydrolyzed at neutral pH and 30°C using a panel of four…”
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