Search Results - "Mayer, Aaron"

Integrated imaging and molecular analysis to decipher tumor microenvironment in the era of immunotherapy by Wu, Jia, Mayer, Aaron T., Li, Ruijiang

“…Radiological imaging is an integral component of cancer care, including diagnosis, staging, and treatment response monitoring. It contains rich information…”
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ICOS Is an Indicator of T-cell-Mediated Response to Cancer Immunotherapy by Xiao, Zunyu, Mayer, Aaron T, Nobashi, Tomomi W, Gambhir, Sanjiv S

“…Immunotherapy is innovating clinical cancer management. Nevertheless, only a small fraction of patient's benefit from current immunotherapies. To improve…”
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The Immunoimaging Toolbox by Mayer, Aaron T, Gambhir, Sanjiv S

“…The recent clinical success of cancer immunotherapy has renewed interest in the development of tools to image the immune system. In general, immunotherapies…”
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Novel Radiotracer for ImmunoPET Imaging of PD‑1 Checkpoint Expression on Tumor Infiltrating Lymphocytes by Natarajan, Arutselvan, Mayer, Aaron T, Xu, Lingyun, Reeves, Robert E, Gano, Jacob, Gambhir, Sanjiv S

“…Immune checkpoint signaling through the programmed death 1 (PD-1) axis to its ligand (PD-L1) significantly dampens anti-tumor immune responses. Cancer patients…”
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Seagrass- and wood-based cement boards: A comparative study in terms of physico-mechanical and structural properties by Kilian Mayer, Aaron, Kuqo, Aldi, Koddenberg, Tim, Mai, Carsten

“…The inclusion and management of local, natural resources in the construction sector are on the rise as a result of the undisputed essentiality of…”
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Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging by Maute, Roy L., Gordon, Sydney R., Mayer, Aaron T., McCracken, Melissa N., Natarajan, Arutselvan, Ring, Nan Guo, Kimura, Richard, Tsai, Jonathan M., Manglik, Aashish, Kruse, Andrew C., Gambhir, Sanjiv S., Weissman, Irving L., Ring, Aaron M.

“…Signaling through the immune checkpoint programmed cell death protein-1 (PD-1) enables tumor progression by dampening antitumor immune responses. Therapeutic…”
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Practical Immuno-PET Radiotracer Design Considerations for Human Immune Checkpoint Imaging by Mayer, Aaron T, Natarajan, Arutselvan, Gordon, Sydney R, Maute, Roy L, McCracken, Melissa N, Ring, Aaron M, Weissman, Irving L, Gambhir, Sanjiv S

“…Immune checkpoint blockade has emerged as a promising cancer treatment paradigm. Unfortunately, there are still a large number of patients and malignancies…”
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Development of Novel ImmunoPET Tracers to Image Human PD-1 Checkpoint Expression on Tumor-Infiltrating Lymphocytes in a Humanized Mouse Model by Natarajan, Arutselvan, Mayer, Aaron T., Reeves, Robert E., Nagamine, Claude M., Gambhir, Sanjiv Sam

“…Purpose It is well known that cancers exploit immune checkpoints (programmed death 1 receptor (PD-1) and its ligand (PD-L1)) to evade anti-tumor immune…”
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Unveiling Spatial Immune Cell Profile in Kidney Allograft Rejections Using 36-plex Immunofluorescence Imaging by Hirai, Toshihito, Kondo, Ayano, Shimizu, Tomokazu, Fukuda, Hironori, Tokita, Daisuke, Takagi, Toshio, Mayer, Aaron T, Ishida, Hideki

“…Kidney allograft rejections are orchestrated by a variety of immune cells. Because of the complex histopathologic features, accurate pathological diagnosis…”
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Imaging activated T cells predicts response to cancer vaccines by Alam, Israt S, Mayer, Aaron T, Sagiv-Barfi, Idit, Wang, Kezheng, Vermesh, Ophir, Czerwinski, Debra K, Johnson, Emily M, James, Michelle L, Levy, Ronald, Gambhir, Sanjiv S

“…In situ cancer vaccines are under active clinical investigation, given their reported ability to eradicate both local and disseminated malignancies…”
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Activating Immune Recognition in Pancreatic Ductal Adenocarcinoma via Autophagy Inhibition, MEK Blockade, and CD40 Agonism by Jiang, Honglin, Courau, Tristan, Borison, Joseph, Ritchie, Alexa J., Mayer, Aaron T., Krummel, Matthew F., Collisson, Eric A.

“…Patients with pancreatic ductal adenocarcinoma (PDA) have not yet benefitted from the revolution in cancer immunotherapy due in large part to a dominantly…”
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Deriving spatial features from in situ proteomics imaging to enhance cancer survival analysis by Dayao, Monica T, Trevino, Alexandro, Kim, Honesty, Ruffalo, Matthew, D’Angio, H Blaize, Preska, Ryan, Duvvuri, Umamaheswar, Mayer, Aaron T, Bar-Joseph, Ziv

“…Abstract Motivation Spatial proteomics data have been used to map cell states and improve our understanding of tissue organization. More recently, these…”
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Whole-body PET Imaging of T-cell Response to Glioblastoma by Nobashi, Tomomi W, Mayer, Aaron T, Xiao, Zunyu, Chan, Carmel T, Chaney, Aisling M, James, Michelle L, Gambhir, Sanjiv S

“…Immunotherapy is a promising approach for many oncological malignancies, including glioblastoma, however, there are currently no available tools or biomarkers…”
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Single‐Cell Transcriptomic Census of Endothelial Changes Induced by Matrix Stiffness and the Association with Atherosclerosis by Zamani, Maedeh, Cheng, Yu‐Hao, Charbonier, Frank, Gupta, Vivek Kumar, Mayer, Aaron T., Trevino, Alexandro E., Quertermous, Thomas, Chaudhuri, Ovijit, Cahan, Patrick, Huang, Ngan F.

“…Vascular endothelial cell (EC) plasticity plays a critical role in the progression of atherosclerosis by giving rise to mesenchymal phenotypes in the plaque…”
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Spatial insights into immunotherapy response in non-small cell lung cancer (NSCLC) by multiplexed tissue imaging by Monkman, James, Moradi, Afshin, Yunis, Joseph, Ivison, Geoff, Mayer, Aaron, Ladwa, Rahul, O'Byrne, Ken, Kulasinghe, Arutha

“…The spatial localisation of immune cells within tumours are key to understand the intercellular communications that can dictate clinical outcomes. Here, we…”
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Microenvironmental network of clonal CXCL13+CD4+ T cells and Tregs in pemphigus chronic blisters by Han, Dawoon, Lee, A Yeong, Kim, Taehee, Choi, Ji Young, Cho, Mi Yeon, Song, Ahreum, Kim, Changhyeon, Shim, Joon Ho, Kim, Hyun Je, Kim, Honesty, D'Angio, Hillary Blaize, Preska, Ryan, Mayer, Aaron T, Kim, Miri, Choi, Eun-Ji, Kim, Tae-Gyun, Shin, Eui-Cheol, Park, Kyemyung, Kim, Do-Young, Kim, Soo-Chan, Kim, Jong Hoon

“…BACKGROUNDPemphigus, a rare autoimmune bullous disease mediated by antidesmoglein autoantibodies, can be controlled with systemic medication like rituximab and…”
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Biodegradable Fluorescent Nanoparticles for Endoscopic Detection of Colorectal Carcinogenesis by Rogalla, Stephan, Flisikowski, Krzysztof, Gorpas, Dimitris, Mayer, Aaron T., Flisikowska, Tatiana, Mandella, Michael J., Ma, Xiaopeng, Casey, Kerriann M., Felt, Stephen A., Saur, Dieter, Ntziachristos, Vasilis, Schnieke, Angelika, Contag, Christopher H., Gambhir, Sanjiv S., Harmsen, Stefan

“…Early and comprehensive endoscopic detection of colonic dysplasia—the most clinically significant precursor lesion to colorectal adenocarcinoma—provides an…”
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Investigations of the Chemical Distribution in Sorbitol and Citric Acid (SorCA) Treated Wood—Development of a Quality Control Method on the Basis of Electromagnetic Radiation by Katarzyna Kurkowiak, Aaron K. Mayer, Lukas Emmerich, Holger Militz

“…Recent studies showed treatments with sorbitol and citric acid (SorCA) to significantly improve the dimensional stability and biological durability of wood…”
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Visualization of Activated T Cells by OX40-ImmunoPET as a Strategy for Diagnosis of Acute Graft-versus-Host Disease by Alam, Israt S, Simonetta, Federico, Scheller, Lukas, Mayer, Aaron T, Murty, Surya, Vermesh, Ophir, Nobashi, Tomomi W, Lohmeyer, Juliane K, Hirai, Toshihito, Baker, Jeanette, Lau, Kenneth H, Negrin, Robert, Gambhir, Sanjiv S

“…Graft-versus-host disease (GvHD) is a major complication of allogeneic hematopoietic cell transplantation (HCT), mediated primarily by donor T cells that…”
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Spatial proteomics of human diabetic kidney disease, from health to class III by Kondo, Ayano, McGrady, Monee, Nallapothula, Dhiraj, Ali, Hira, Trevino, Alexandro E., Lam, Amy, Preska, Ryan, D’Angio, H. Blaize, Wu, Zhenqin, Lopez, Lauren N., Badhesha, Harshanna K., Vargas, Chenoa R., Ramesh, Achyuta, Wiegley, Nasim, Han, Seung Seok, Dall’Era, Marc, Jen, Kuang-Yu, Mayer, Aaron T., Afkarian, Maryam

“…Aims/hypothesis Diabetic kidney disease (DKD) is the leading cause of chronic and end-stage kidney disease in the USA and worldwide. Animal models have taught…”
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