Impaired olfactory bulb neurogenesis depends on the presence of human wild-type alpha-synuclein

Highlights ► Regulatable expression of human wild-type alpha-synuclein in the SVZ/OB neurogenic region. ► Impaired adult OB neurogenesis partially rescued in GCL/GLOM. ► Rescue of newly generated dopaminergic neurons in the OB. ► Intracytoplasmic BrdU+ particles within microglia indicate phagocytosi...

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Published in:	Neuroscience Vol. 222; pp. 343 - 355
Main Authors:	May, V.E.L, Nuber, S, Marxreiter, F, Riess, O, Winner, B, Winkler, J
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier Ltd 11-10-2012 Elsevier
Subjects:	adult neurogenesis alpha-Synuclein - metabolism alpha-Synuclein - physiology Animals Antimetabolites Biological and medical sciences Biomarkers - metabolism Blotting, Western Brain - pathology Bromodeoxyuridine Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics Calcium-Calmodulin-Dependent Protein Kinase Type 2 - physiology Cell Count Cell Differentiation - physiology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Humans Immunohistochemistry Inflammation - pathology Medical sciences Mice Mice, Inbred C57BL Mice, Transgenic microglia Nerve Tissue Proteins - metabolism neural progenitor cells Neurogenesis - physiology Neuroglia - drug effects Neuroglia - physiology Neurology Nuclear Proteins - metabolism Olfactory Bulb - growth & development Olfactory Bulb - metabolism Olfactory system and olfaction. Gustatory system and gustation Parkinson’s disease synucleinopathy tet-off Vertebrates: nervous system and sense organs human wild-type alpha-synuclein transgenic mice synucleinopathy glomerular cell layer 5-bromo-2′-deoxyuridine Iba1 Thy1 dox doxycycline CaM_α-syn platelet-derived growth factor β calcium/calmodulin-dependent protein kinase IIα OB SVZ rostral migratory stream microglia tet-off subventricular zone adult neurogenesis GLOM olfactory bulb tet ionized calcium-binding adaptor molecule 1 neuron-specific nuclear protein alpha-synuclein granular cell layer neural progenitor cells GFAP tyrosine hydroxylase GCL CaMKII NeuN PD TH thymocyte differentiation antigen 1 α-syn human wild-type alpha-synuclein transgenic mice plus treatment with doxycycline PDGFβ RMS CaM_α-syn + dox tetracycline glial fibrillary acidic protein BrdU Parkinson’s disease CaM_α-syn+dox Human Nervous system diseases Parkinson's disease Neuroglia Central nervous system Precursor cell Parkinson disease Neurogenesis Encephalon Cerebral disorder Microglia Olfactory pathway Central nervous system disease Olfactory bulb Degenerative disease α-synuclein Extrapyramidal syndrome Progenitor cell
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Summary:	Highlights ► Regulatable expression of human wild-type alpha-synuclein in the SVZ/OB neurogenic region. ► Impaired adult OB neurogenesis partially rescued in GCL/GLOM. ► Rescue of newly generated dopaminergic neurons in the OB. ► Intracytoplasmic BrdU+ particles within microglia indicate phagocytosis of new NPC.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.07.001