Search Results - "May, Sarah C"

Discordant Effects of Polyamine Depletion by DENSpm and DFMO on β-cell Cytokine Stress and Diabetes Outcomes in Mice by Hammoud, Batoul, Nelson, Jennifer B, May, Sarah C, Tersey, Sarah A, Mirmira, Raghavendra G

“…Abstract Type 1 diabetes (T1D) is an autoimmune disease leading to dysfunction and loss of insulin-secreting β cells. In β cells, polyamines have been…”
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Non-Alcoholic Fatty Liver Disease: Translating Disease Mechanisms into Therapeutics Using Animal Models by Basha, Amina, May, Sarah C, Anderson, Ryan M, Samala, Niharika, Mirmira, Raghavendra G

“…Nonalcoholic fatty liver disease (NAFLD) is a range of pathologies arising from fat accumulation in the liver in the absence of excess alcohol use or other…”
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Human variant of scavenger receptor BI (R174C) exhibits impaired cholesterol transport functions by May, Sarah C., Dron, Jacqueline S., Hegele, Robert A., Sahoo, Daisy

“…HDL and its primary receptor, scavenger receptor class B type I (SR-BI), work together to promote the clearance of excess plasma cholesterol, thereby…”
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Protocol to isolate immune cells from mouse pancreatic lymph nodes and whole pancreas for mass cytometric analyses by Nargis, Titli, Piñeros, Annie R., May, Sarah C., Tersey, Sarah A., Mirmira, Raghavendra G.

“…Investigating the immune attack on β cells is critical to understanding autoimmune diabetes. Here, we present a protocol to isolate immune cells from mouse…”
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A short amphipathic alpha helix in scavenger receptor BI facilitates bidirectional HDL-cholesterol transport by May, Sarah C., Sahoo, Daisy

“…During reverse cholesterol transport, high-density lipoprotein (HDL) carries excess cholesterol from peripheral cells to the liver for excretion in bile. The…”
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Stress and human health in diabetes: A report from the 19th Chicago Biomedical Consortium symposium by Mirmira, Raghavendra G, Kulkarni, Rohit N, Xu, Pingwen, Drossos, Tina, Varady, Krista, Knutson, Kristen L, Reutrakul, Sirimon, Martyn-Nemeth, Pamela, Sargis, Robert M, Wallia, Amisha, Tuchman, Arleen M, Weissberg-Benchell, Jill, Danielson, Kirstie K, Oakes, Scott A, Thomas, Celeste C, Layden, Brian T, May, Sarah C, Michelle Burbea Hoffmann, Gatta, Eleonora, Solway, Julian, Philipson, Louis H

“…Stress and diabetes coexist in a vicious cycle. Different types of stress lead to diabetes, while diabetes itself is a major life stressor. This was the focus…”
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Inside the β Cell: Molecular Stress Response Pathways in Diabetes Pathogenesis by Kulkarni, Abhishek, Muralidharan, Charanya, May, Sarah C, Tersey, Sarah A, Mirmira, Raghavendra G

“…Abstract The pathogeneses of the 2 major forms of diabetes, type 1 and type 2, differ with respect to their major molecular insults (loss of immune tolerance…”
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RNA Splicing Events in Circulation Distinguish Individuals with and without New-Onset Type 1 Diabetes by Webb-Robertson, Bobbie-Jo M, Wu, Wenting, Flores, Javier E, Bramer, Lisa M, Syed, Farooq, Tersey, Sarah A, May, Sarah C, Sims, Emily K, Evans-Molina, Carmella, Mirmira, Raghavendra G

“…Alterations in RNA splicing may influence protein isoform diversity that contributes to or reflects the pathophysiology of certain diseases. Whereas specific…”
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Inhibition of the eukaryotic initiation factor-2α kinase PERK decreases risk of autoimmune diabetes in mice by Muralidharan, Charanya, Huang, Fei, Enriquez, Jacob R, Wang, Jiayi E, Nelson, Jennifer B, Nargis, Titli, May, Sarah C, Chakraborty, Advaita, Figatner, Kayla T, Navitskaya, Svetlana, Anderson, Cara M, Calvo, Veronica, Surguladze, David, Mulvihill, Mark J, Yi, Xiaoyan, Sarkar, Soumyadeep, Oakes, Scott A, Webb-Robertson, Bobbie-Jo M, Sims, Emily K, Staschke, Kirk A, Eizirik, Decio L, Nakayasu, Ernesto S, Stokes, Michael E, Tersey, Sarah A, Mirmira, Raghavendra G

“…Preventing the onset of autoimmune type 1 diabetes (T1D) is feasible through pharmacological interventions that target molecular stress-responsive mechanisms…”
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Pcpe2, a Novel Extracellular Matrix Protein, Regulates Adipocyte SR-BI–Mediated High-Density Lipoprotein Uptake by Xu, Hao, Thomas, Michael J., Kaul, Sushma, Kallinger, Rachel, Ouweneel, Amber B., Maruko, Elisa, Oussaada, Sabrina M., Jongejan, Aldo, Cense, Huib A., Nieuwdorp, Max, Serlie, Mireille J., Goldberg, Ira J., Civelek, Mete, Parks, Brian W., Lusis, Aldons J., Knaack, Darcy, Schill, Rebecca L., May, Sarah C., Reho, John J., Grobe, Justin L., Gantner, Benjamin, Sahoo, Daisy, Sorci-Thomas, Mary G.

“…To investigate the role of adipocyte Pcpe2 (procollagen C-endopeptidase enhancer 2) in SR-BI (scavenger receptor class BI)-mediated HDL-C (high-density…”
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12-Lipoxygenase inhibition delays onset of autoimmune diabetes in human gene replacement mice by Nargis, Titli, Muralidharan, Charanya, Enriquez, Jacob R., Wang, Jiayi E., Kaylan, Kerim B., Chakraborty, Advaita, Pratuangtham, Sarida, Figatner, Kayla, Nelson, Jennifer B., May, Sarah C., Nadler, Jerry L., Boxer, Matthew B., Maloney, David J., Tersey, Sarah A., Mirmira, Raghavendra G.

“…Type 1 diabetes (T1D) is characterized by the autoimmune destruction of insulin-producing beta cells and involves an interplay between beta cells and cells of…”
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Stress and human health in diabetes: A report from the 19 th Chicago Biomedical Consortium symposium by Mirmira, Raghavendra G, Kulkarni, Rohit N, Xu, Pingwen, Drossos, Tina, Varady, Krista, Knutson, Kristen L, Reutrakul, Sirimon, Martyn-Nemeth, Pamela, Sargis, Robert M, Wallia, Amisha, Tuchman, Arleen M, Weissberg-Benchell, Jill, Danielson, Kirstie K, Oakes, Scott A, Thomas, Celeste C, Layden, Brian T, May, Sarah C, Burbea Hoffmann, Michelle, Gatta, Eleonora, Solway, Julian, Philipson, Louis H

“…Stress and diabetes coexist in a vicious cycle. Different types of stress lead to diabetes, while diabetes itself is a major life stressor. This was the focus…”
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Inside the [beta] Cell: Molecular Stress Response Pathways in Diabetes Pathogenesis by Kulkarni, Abhishek, Muralidharan, Charanya, May, Sarah C, Tersey, Sarah A, Mirmira, Raghavendra G

“…The pathogeneses of the 2 major forms of diabetes, type 1 and type 2, differ with respect to their major molecular insults (loss of immune tolerance and onset…”
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Inhibition of the eukaryotic initiation factor-2[alpha] kinase PERK decreases risk of autoimmune diabetes in mice by Muralidharan, Charanya, Huang, Fei, Enriquez, Jacob R, Wang, Jiayi E, Nelson, Jennifer B, Nargis, Titli, May, Sarah C, Chakraborty, Advaita, Figatner, Kayla T, Navitskaya, Svetlana, Anderson, Cara M, Calvo, Veronica, Surguladze, David, Mulvihill, Mark J, Yi, Xiaoyan, Sarkar, Soumyadeep, Oakes, Scott A, Webb-Robertson, Bobbie-Jo M, Sims, Emily K, Staschke, Kirk A, Eizirik, Decio L, Nakayasu, Ernesto S, Stokes, Michael E, Tersey, Sarah A, Mirmira, Raghavendra G

“…Preventing the onset of autoimmune type 1 diabetes (T1D) is feasible through pharmacological interventions that target molecular stress-responsive mechanisms…”
Get full text

Pcpe2, a Novel Extracellular Matrix Protein, Regulates Adipocyte SR-BI–Mediated High-Density Lipoprotein Uptake by Xu, Hao, Thomas, Michael J., Kaul, Sushma, Kallinger, Rachel, Ouweneel, Amber B., Maruko, Elisa, Oussaada, Sabrina M., Jongejan, Aldo, Cense, Huib A., Nieuwdorp, Max, Serlie, Mireille J., Goldberg, Ira J., Civelek, Mete, Parks, Brian W., Lusis, Aldons J., Knaack, Darcy, Schill, Rebecca L., May, Sarah C., Reho, John J., Grobe, Justin L., Gantner, Benjamin, Sahoo, Daisy, Sorci-Thomas, Mary G.

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Pcpe2, a Novel Extracellular Matrix Protein, Regulates Adipocyte SR-BI-Mediated HDL Uptake by Xu, Hao, Thomas, Michael J., Kaul, Sushma, Kallinger, Rachel, Ouweneel, Amber B., Maruko, Elisa, Oussaada, Sabrina M., Jongejan, Aldo, Cense, Huib A., Nieuwdorp, Max, Serlie, Mireille J., Goldberg, Ira J., Civelek, Mete, Parks, Brian W., Lusis, Aldons J., Knaack, Darcy, Schill, Rebecca L., May, Sarah C., Reho, John J., Grobe, Justin L., Gantner, Benjamin, Sahoo, Daisy, Sorci-Thomas, Mary G.

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OR12-01 Blocking The Maladaptive Integrated Stress Response Increases Immunosuppressive PD-L1 In Pancreatic β-Cells by Muralidharan, Charanya, Huiping huang, Fei, May, Sarah C, Enriquez, Jacob, Nelson, Jennifer B, Wang, Eugenia, Chakraborthy, Advaita, Figatner, Kayla T, Navitskaya, Svetlana N, Tersey, Sarah A, Mirmira, Raghavendra G

“…Abstract Disclosure: C. Muralidharan: None. F.H. huang: None. S.C. May: None. J. Enriquez: None. J.B. Nelson: None. E. Wang: None. A. Chakraborthy: None. K.T…”
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Do some patients receive unnecessary parenteral nutrition after pancreatoduodenectomy? Results from an international multicentre study by Thomas B. Russell, Peter L. Labib, Paula Murphy, Fabio Ausania, Elizabeth Pando, Keith J. Roberts, Ambareen Kausar, Vasileios K. Mavroeidis, Gabriele Marangoni, Sarah C. Thomasset, Adam E. Frampton, Pavlos Lykoudis, Manuel Maglione, Nassir Alhaboob, Hassaan Bari, Andrew M. Smith, Duncan Spalding, Parthi Srinivasan, Brian R. Davidson, Ricky H. Bhogal, Daniel Croagh, Ismael Dominguez, Rohan Thakkar, Dhanny Gomez, Michael A. Silva, Pierfrancesco Lapolla, Andrea Mingoli, Alberto Porcu, Nehal S. Shah, Zaed Z. R. Hamady, Bilal Al-Sarrieh, Alejandro Serrablo, Somaiah Aroori

“…Backgrounds/Aims: After pancreatoduodenectomy (PD), an early oral diet is recommended; however, the postoperative nutritional management of PD patients is…”
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Does an extensive diagnostic workup for upfront resectable pancreatic cancer result in a delay which affects survival? Results from an international multicentre study by Thomas B. Russell, Peter L. Labib, Jemimah Denson, Fabio Ausania, Elizabeth Pando, Keith J. Roberts, Ambareen Kausar, Vasileios K. Mavroeidis, Gabriele Marangoni, Sarah C. Thomasset, Adam E. Frampton, Pavlos Lykoudis, Manuel Maglione, Nassir Alhaboob, Hassaan Bari, Andrew M. Smith, Duncan Spalding, Parthi Srinivasan, Brian R. Davidson, Ricky H. Bhogal, Daniel Croagh, Ashray Rajagopalan, Ismael Dominguez, Rohan Thakkar, Dhanny Gomez, Michael A. Silva, Pierfrancesco Lapolla, Andrea Mingoli, Alberto Porcu, Teresa Perra, Nehal S. Shah, Zaed Z. R. Hamady, Bilal Al-Sarrieh, Alejandro Serrablo, Somaiah Aroori

“…Backgrounds/Aims: Pancreatoduodenectomy (PD) is recommended in fit patients with a carcinoma (PDAC) of the pancreatic head, and a delayed resection may affect…”
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