Search Results - "May, Michael J."

NF-κB inhibitor targeted to activated endothelium demonstrates a critical role of endothelial NF-κB in immune-mediated diseases by Sehnert, Bettina, Burkhardt, Harald, Wessels, Johannes T., Schröder, Agnes, May, Michael J., Vestweber, Dietmar, Zwerina, Jochen, Warnatz, Klaus, Nimmerjahn, Falk, Schett, Georg, Dübel, Stefan, Voll, Reinhard Edmund

“…Activation of the nuclear transcription factor κB (NF-κB) regulates the expression of inflammatory genes crucially involved in the pathogenesis of inflammatory…”
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Hypomorphic nuclear factor-κB essential modulator mutation database and reconstitution system identifies phenotypic and immunologic diversity by Hanson, Eric P., MD, Monaco-Shawver, Linda, BA, Solt, Laura A., BS, Madge, Lisa A., PhD, Banerjee, Pinaki P., PhD, May, Michael J., PhD, Orange, Jordan S., MD, PhD

“…Background Human hypomorphic nuclear factor-κB essential modulator (NEMO) mutations cause diverse clinical and immunologic phenotypes, but understanding of…”
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Requirement of FADD, NEMO, and BAX/BAK for Aberrant Mitochondrial Function in Tumor Necrosis Factor Alpha-Induced Necrosis by Irrinki, Krishna M., Mallilankaraman, Karthik, Thapa, Roshan J., Chandramoorthy, Harish C., Smith, Frank J., Jog, Neelakshi R., Gandhirajan, Rajesh Kumar, Kelsen, Steven G., Houser, Steven R., May, Michael J., Balachandran, Siddharth, Madesh, Muniswamy

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A phase I clinical trial of systemically delivered NEMO binding domain peptide in dogs with spontaneous activated B-cell like diffuse large B-cell lymphoma by Habineza Ndikuyeze, Georges, Gaurnier-Hausser, Anita, Patel, Reema, Baldwin, Albert S, May, Michael J, Flood, Patrick, Krick, Erika, Propert, Kathleen J, Mason, Nicola J

“…Activated B-Cell (ABC) Diffuse Large B-Cell Lymphoma (DLBCL) is a common, aggressive and poorly chemoresponsive subtype of DLBCL, characterized by constitutive…”
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Triggering ubiquitination of IFNAR1 protects tissues from inflammatory injury by Bhattacharya, Sabyasachi, Katlinski, Kanstantsin V, Reichert, Maximilian, Takano, Shigetsugu, Brice, Angela, Zhao, Bin, Yu, Qiujing, Zheng, Hui, Carbone, Christopher J, Katlinskaya, Yuliya V, Leu, N Adrian, McCorkell, Kelly A, Srinivasan, Satish, Girondo, Melanie, Rui, Hallgeir, May, Michael J, Avadhani, Narayan G, Rustgi, Anil K, Fuchs, Serge Y

“…Type 1 interferons (IFN) protect the host against viruses by engaging a cognate receptor (consisting of IFNAR1/IFNAR2 chains) and inducing downstream signaling…”
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The NFκB paradox: RelB induces and inhibits gene expression by Madge, Lisa A., May, Michael J.

“…Comment on: Madge LA, et al. J Biol Chem 2010; 285:38069-77…”
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RelB Forms Transcriptionally Inactive Complexes with RelA/p65 by Marienfeld, Ralf, May, Michael J., Berberich, Ingolf, Serfling, Edgar, Ghosh, Sankar, Neumann, Manfred

“…RelB is an unusual member of the NF-κB transcription factor family that acts as both a transcriptional activator as well as a repressor of NF-κB-dependent gene…”
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STIM- and Orai-mediated calcium entry controls NF-κB activity and function in lymphocytes by Berry, Corbett T., May, Michael J., Freedman, Bruce D.

“…[Display omitted] •Antigen binding to the lymphocyte antigen receptor triggers STIM and Orai mediated Ca2+ entry.•Antigen induced [Ca2+] dynamics reflect the…”
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Understanding high endothelial venules: Lessons for cancer immunology by Ager, Ann, May, Michael J

“…High endothelial venules (HEVs) are blood vessels especially adapted for lymphocyte trafficking which are normally found in secondary lymphoid organs such as…”
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Selective inhibition of NF‐κB in dendritic cells by the NEMO‐binding domain peptide blocks maturation and prevents T cell proliferation and polarization by Tas, Sander W., de Jong, Esther C., Hajji, Najat, May, Michael J., Ghosh, Sankar, Vervoordeldonk, Margriet J., Tak, Paul P.

“…Dendritic cells (DC) are the only antigen‐presenting cells for naive T cells and, therefore, they are crucial players in the initiation of immune responses…”
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IL-17R signaling: new players get in on the Act1 by May, Michael J

“…Proinflammatory signaling by the interleukin 17 receptor requires the adaptor Act1. Two studies identify an additional function for Act1 and identify new…”
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Opening Orai's to see B-yond current paradigms by O'Connor, Roderick S., May, Michael J., Freedman, Bruce D.

“…[Display omitted]…”
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BCR-Induced Ca2+ Signals Dynamically Tune Survival, Metabolic Reprogramming, and Proliferation of Naive B Cells by Berry, Corbett T., Liu, Xiaohong, Myles, Arpita, Nandi, Satabdi, Chen, Youhai H., Hershberg, Uri, Brodsky, Igor E., Cancro, Michael P., Lengner, Christopher J., May, Michael J., Freedman, Bruce D.

“…B cell receptor (BCR) engagement induces naive B cells to differentiate and perform critical immune-regulatory functions. Acquisition of functional specificity…”
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Analysis of Calcium Control of Canonical NF-κB Signaling in B Lymphocytes by Berry, Corbett T, May, Michael J, Freedman, Bruce D

“…The central role of calcium (Ca ) signaling in lymphocyte development and acquisition of functional immunity and tolerance is well established. Ca signals are…”
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Epithelial-cell-intrinsic IKK-β expression regulates intestinal immune homeostasis by ZAPH, Colby, TROY, Amy E, ECKMANN, Lars, KARIN, Michael, ARTIS, David, TAYLOR, Betsy C, BERMAN-BOOTY, Lisa D, GUILD, Katherine J, YURONG DU, YOST, Evan A, GRUBER, Achim D, MAY, Michael J, GRETEN, Florian R

“…Intestinal epithelial cells (IECs) provide a primary physical barrier against commensal and pathogenic microorganisms in the gastrointestinal (GI) tract, but…”
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T Cell Receptor-induced Nuclear Factor κB (NF-κB) Signaling and Transcriptional Activation Are Regulated by STIM1- and Orai1-mediated Calcium Entry by Liu, Xiaohong, Berry, Corbett T., Ruthel, Gordon, Madara, Jonathan J., MacGillivray, Katelyn, Gray, Carolyn M., Madge, Lisa A., McCorkell, Kelly A., Beiting, Daniel P., Hershberg, Uri, May, Michael J., Freedman, Bruce D.

“…T cell activation following antigen binding to the T cell receptor (TCR) involves the mobilization of intracellular Ca2+ to activate the key transcription…”
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Epithelial-intrinsic IKKα expression regulates group 3 innate lymphoid cell responses and antibacterial immunity by Giacomin, Paul R, Moy, Ryan H, Noti, Mario, Osborne, Lisa C, Siracusa, Mark C, Alenghat, Theresa, Liu, Bigang, McCorkell, Kelly A, Troy, Amy E, Rak, Gregory D, Hu, Yinling, May, Michael J, Ma, Hak-Ling, Fouser, Lynette A, Sonnenberg, Gregory F, Artis, David

“…Innate lymphoid cells (ILCs) are critical for maintaining epithelial barrier integrity at mucosal surfaces; however, the tissue-specific factors that regulate…”
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The Phosphorylation Status of Nuclear NF-ΚB Determines Its Association with CBP/p300 or HDAC-1 by Zhong, Haihong, May, Michael J, Jimi, Eijiro, Ghosh, Sankar

“…Homodimers of the NF-ΚB p50 subunit are transcriptionally repressive in cells, whereas they can promote transcription in vitro, suggesting that their…”
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Lymph node formation and B cell homeostasis require IKK-α in distinct endothelial cell–derived compartments by McCorkell, Kelly A., Jayachandran, Nipun, Cully, Michelle D., Freund-Brown, Jacquelyn, Weinkopff, Tiffany, Monslow, James, Hu, Yinling, Puré, Ellen, Freedman, Bruce D., Alvarez, Jorge I., Cancro, Michael P., May, Michael J.

“…Global inactivation of IκB kinase (IKK)-α results in defective lymph node (LN) formation and B cell maturation, and loss of IKK-α–dependent noncanonical NF-κB…”
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Classical NF-κB Activation Negatively Regulates Noncanonical NF-κB-dependent CXCL12 Expression by Madge, Lisa A., May, Michael J.

“…Ligation of the lymphotoxin-β receptor (LTβR) by LIGHT (lymphotoxin-related inducible ligand that competes for glycoprotein D binding to herpes virus entry…”
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