Search Results - "May, LT"

The apelin receptor inhibits the angiotensin II type 1 receptor via allosteric trans‐inhibition by Siddiquee, K, Hampton, J, McAnally, D, May, LT, Smith, LH

“…This article is commented on by Goupil et al., pp. 1101‐1103 of this issue. Background and Purpose The apelin receptor (APJ) is often co‐expressed with the…”
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Interleukin 6 is Expressed in High Levels in Psoriatic Skin and Stimulates Proliferation of Cultured Human Keratinocytes by Grossman, Rachel M., Krueger, James, Yourish, Debra, Granelli-Piperno, Angela, Murphy, Daniel P., May, Lester T., Kupper, Thomas S., Sehgal, Pravinkumar B., Gottlieb, Alice B.

“…Psoriasis is a common papulosquamous skin disease. The histopathology is characterized by epidermal hyperplasia and inflammation. Recent studies suggest that…”
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A kinetic view of GPCR allostery and biased agonism by Lane, J Robert, May, Lauren T, Parton, Robert G, Sexton, Patrick M, Christopoulos, Arthur

“…Allosteric modulation and biased agonism at GPCRs could be manifestations of the same underlying 'conformational selection' mechanism, and these can be…”
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Allosteric modulators of G-protein-coupled receptors by May, Lauren T, Christopoulos, Arthur

“…Allosteric modulators of G-protein-coupled receptors (GPCRs) interact with binding sites on the receptor that are topographically distinct from the orthosteric…”
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Allosteric modulation of G protein-coupled receptors by May, L T, Avlani, V A, Sexton, P M, Christopoulos, A

“…G protein-coupled receptors (GPCRs) constitute the largest receptor superfamily in the human genome and represent the most common targets of drug action…”
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G-protein-coupled receptor allosterism: the promise and the problem(s) by Christopoulos, A, May, L T, Avlani, V A, Sexton, P M

“…Allosteric modulators of G-protein-coupled receptors interact with binding sites that are topographically distinct from the orthosteric site recognized by the…”
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Application of a kinetic model to the apparently complex behavior of negative and positive allosteric modulators of muscarinic acetylcholine receptors by Avlani, Vimesh, May, Lauren T, Sexton, Patrick M, Christopoulos, Arthur

“…The binding of allosteric modulators to G protein-coupled receptors (GPCRs) is often described by an equilibrium allosteric ternary complex model (ATCM). This…”
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Progressive rise in the expression of interleukin-6 in human endometrium during menstrual cycle is initiated during the implantation window by Tabibzadeh, S, Kong, Q F, Babaknia, A, May, L T

“…In order to be prepared for implantation, human endometrium undergoes a predictable series of proliferative and secretory changes. Cytokines play an important…”
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Cytokine-induced production of IFN-beta 2/IL-6 by freshly explanted human endometrial stromal cells. Modulation by estradiol-17 beta by Tabibzadeh, SS, Santhanam, U, Sehgal, PB, May, LT

“…The cytokine IFN-beta 2/IL-6 has emerged as an important means of communication between cells--both within the immune system as well as outside it. In…”
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Transcriptional regulation of the interferon-beta 2/B cell differentiation factor BSF-2/hepatocyte-stimulating factor gene in human fibroblasts by other cytokines by Walther, Z, May, LT, Sehgal, PB

“…Levels of mRNA for IFN-beta 2/B cell differentiation factor2/hepatocyte-stimulating factor (IFN-beta 2) in confluent quiescent cultures of human diploid…”
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Endotoxemia elicits increased circulating beta 2-IFN/IL-6 in man by Fong, Y, Moldawer, LL, Marano, M, Wei, H, Tatter, SB, Clarick, RH, Santhanam, U, Sherris, D, May, LT, Sehgal, PB

“…beta 2-IFN/hepatocyte stimulating factor/IL-6 is a cytokine secreted by monocytes, fibroblasts, and endothelial cells in cell culture that possesses diverse…”
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Multiple forms of IFN-beta 2/IL-6 in serum and body fluids during acute bacterial infection by Helfgott, DC, Tatter, SB, Santhanam, U, Clarick, RH, Bhardwaj, N, May, LT, Sehgal, PB

“…Many of the major alterations in plasma proteins characteristic of the hepatic acute phase response are regulated by IFN-beta 2/IL-6. Using a specific bioassay…”
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Antibodies chaperone circulating IL-6. Paradoxical effects of anti-IL-6 "neutralizing" antibodies in vivo by May, LT, Neta, R, Moldawer, LL, Kenney, JS, Patel, K, Sehgal, PB

“…In the baboon or the mouse, a stimulus such as LPS, TNF, or IL-1 typically led to a rapid induction of circulating IL-6, the levels peaked by 2 to 3 h and then…”
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IL-6/IFN-beta-2 as a circulating hormone. Induction by cytokine administration in humans by Jablons, DM, Mule, JJ, McIntosh, JK, Sehgal, PB, May, LT, Huang, CM, Rosenberg, SA, Lotze, MT

“…IL-6/IFN-beta 2 is a family of phosphoglycoproteins ranging in size from 19 to 30 kDa which elicits a broad range of physiologic and immune responses. Several…”
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Monocyte-Derived Human B-Cell Growth Factor Identified as Interferon-β 2 (BSF-2, IL-6) by Tosato, Giovanna, Seamon, Kenneth B., Goldman, Neil D., Sehgal, Pravinkumar B., May, Lester T., Washington, Glennelle C., Jones, Karen D., Pike, Sandra E.

“…Soluble products of either Epstein-Barr virus (EBV)-infected B cells or activated monocytes promote the proliferation of EBV-infected B cells and permit their…”
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Activation of the Human ``β 2-Interferon/Hepatocyte-Stimulating Factor/Interleukin 6'' Promoter by Cytokines, Viruses, and Second Messenger Agonists by Ray, Anuradha, Tatter, Stephen B., May, Lester T., Sehgal, Pravinkumar B.

“…The hallmark of ``β 2-interferon (IFN-β 2)/hepatocyte-stimulating factor/interleukin 6'' gene expression is its inducibility in different types of human cells…”
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High levels of "complexed" interleukin-6 in human blood by MAY, L. T, VIGUET, H, KENNEY, J. S, IDA, N, ALLISON, A. C, SEHGAL, P. B

“…The biochemical nature of endogenous interleukin-6 (IL-6) as it exists in human serum or plasma was investigated. Serum from a patient following bone marrow…”
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IFN-beta 2/IL-6 augments the activity of human natural killer cells by Luger, TA, Krutmann, J, Kirnbauer, R, Urbanski, A, Schwarz, T, Klappacher, G, Kock, A, Micksche, M, Malejczyk, J, Schauer, E

“…MHC nonrestricted cytotoxic cells play an important role in the killing of tumor cells in vitro and potentially in vivo. The activity of these cells is…”
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A cytokine network in human diploid fibroblasts: interactions of beta-interferons, tumor necrosis factor, platelet-derived growth factor, and interleukin-1 by KOHASE, M, MAY, L. T, TAMM, I, VILCEK, J, SEHGAL, P. B

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Human beta 2 interferon and B-cell differentiation factor BSF-2 are identical by Sehgal, P B, May, L T, Tamm, I, Vilcek, J

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