Search Results - "May, D R"

Preclinical development of CAT‐354, an IL‐13 neutralizing antibody, for the treatment of severe uncontrolled asthma by May, RD, Monk, PD, Cohen, ES, Manuel, D, Dempsey, F, Davis, NHE, Dodd, AJ, Corkill, DJ, Woods, J, Joberty‐Candotti, C, Conroy, LA, Koentgen, F, Martin, EC, Wilson, R, Brennan, N, Powell, J, Anderson, IK

“…BACKGROUND AND PURPOSE IL‐13 is a pleiotropic Th2 cytokine considered likely to play a pivotal role in asthma. Here we describe the preclinical in vitro and in…”
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The complex biology and contribution of Staphylococcus aureus in atopic dermatitis, current and future therapies by Hepburn, L., Hijnen, D.J., Sellman, B.R., Mustelin, T., Sleeman, M.A., May, R.D., Strickland, I.

“…Summary Atopic dermatitis (AD) is a complex, chronic inflammatory skin disorder affecting more than 10% of U.K. children and is a major cause of…”
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The BMP2 variant L51P restores the osteogenic differentiation of human mesenchymal stromal cells in the presence of intervertebral disc cells by Tekari, A, May, R D, Frauchiger, D A, Chan, S C, Benneker, L M, Gantenbein, B

“…Spinal fusion is hampered by the presence of remaining intervertebral disc (IVD) tissue and leads to spinal non-union. While the exact mechanism remains…”
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Dectin-2 sensing of house dust mite is critical for the initiation of airway inflammation by Clarke, D L, Davis, N H E, Campion, C L, Foster, M L, Heasman, S C, Lewis, A R, Anderson, I K, Corkill, D J, Sleeman, M A, May, R D, Robinson, M J

“…How the immune system senses aeroallergens and triggers an aberrant inflammation is poorly understood. Dectin-2 is a house dust mite (HDM)-sensing pattern…”
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Revised experimental upper limit on the electric dipole moment of the neutron by Pendlebury, J. M., Afach, S., Ayres, N. J., Baker, C. A., Ban, G., Bison, G., Bodek, K., Burghoff, M., Geltenbort, P., Green, K., Griffith, W. C., van der Grinten, M., Grujić, Z. D., Harris, P. G., Hélaine, V., Iaydjiev, P., Ivanov, S. N., Kasprzak, M., Kermaidic, Y., Kirch, K., Koch, H.-C., Komposch, S., Kozela, A., Krempel, J., Lauss, B., Lefort, T., Lemière, Y., May, D. J. R., Musgrave, M., Naviliat-Cuncic, O., Piegsa, F. M., Pignol, G., Prashanth, P. N., Quéméner, G., Rawlik, M., Rebreyend, D., Richardson, J. D., Ries, D., Roccia, S., Rozpedzik, D., Schnabel, A., Schmidt-Wellenburg, P., Severijns, N., Shiers, D., Thorne, J. A., Weis, A., Winston, O. J., Wursten, E., Zejma, J., Zsigmond, G.

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The epidemiology of serious eye injuries from the United States Eye Injury Registry by MAY, D. R, KUHN, F. P, MORRIS, R. E, WITHERSPOON, C. D, DANIS, R. P, MATTHEWS, G. P, MANN, L

“…Trauma remains a major problem throughout the world. The prognosis of severe eye injuries is commonly bleak. This paper focuses on the epidemiology of eye…”
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Development of semisynthetic triterpenoid saponin derivatives with immune stimulating activity by Marciani, D.J., Press, J.B., Reynolds, R.C., Pathak, A.K., Pathak, V., Gundy, L.E., Farmer, J.T., Koratich, M.S., May, R.D.

“…Aldehyde-containing triterpene saponins have adjuvant properties, but only those from Quillaja saponaria Molina stimulate the production of cytotoxic T…”
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Structural Characterisation Reveals Mechanism of IL-13-Neutralising Monoclonal Antibody Tralokinumab as Inhibition of Binding to IL-13Rα1 and IL-13Rα2 by Popovic, B., Breed, J., Rees, D.G., Gardener, M.J., Vinall, L.M.K., Kemp, B., Spooner, J., Keen, J., Minter, R., Uddin, F., Colice, G., Wilkinson, T., Vaughan, T., May, R.D.

“…Interleukin (IL)-13 is a pleiotropic T helper type 2 cytokine frequently associated with asthma and atopic dermatitis. IL-13-mediated signalling is initiated…”
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Hydrogen radicals, nitrogen radicals, and the production of O3 in the upper troposphere by Wennberg, PO, Hanisco, TF, Jaegle, L, Jacob, DJ, Hintsa, EJ, Lanzendorf, EJ, Anderson, JG, Gao, R, Keim, ER, Donnelly, SG, Negro, LAD, Fahey, DW, McKeen, SA, Salawitch, RJ, Webster, CR, May, RD, Herman, RL, Proffitt, MH, Margitan, JJ, Atlas, EL, Schauffler, SM, Flocke, F, McElroy, CT, Bui, TP

“…The concentrations of the hydrogen radicals OH and HO2 in the middle and upper troposphere were measured simultaneously with those of NO, O3, CO, H2O, CH4,…”
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Validating AIRS upper atmosphere water vapor retrievals using aircraft and balloon in situ measurements by Hagan, D. E., Webster, C. R., Farmer, C. B., May, R. D., Herman, R. L., Weinstock, E. M., Christensen, L. E., Lait, L. R., Newman, P. A.

“…This paper provides an initial assessment of the accuracy of the Atmospheric Infrared Sounder (AIRS) water vapor retrievals from 500 to 100 mbar. AIRS…”
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Removal of stratospheric O3 by radicals : in situ measurements of OH, HO2, NO, NO2, ClO, and BrO by WENNBERG, P. O, COHEN, R. C, WEBSTER, C. R, MAY, R. D, TOOHEY, D. W, AVALLONE, L. M, PROFFITT, M. H, LOEWENSTEIN, M, PODOLSKE, J. R, CHAN, K. R, WOFSY, S. C, STIMPFLE, R. M, KOPLOW, J. P, ANDERSON, J. G, SALAWITCH, R. J, FAHEY, D. W, WOODBRIDGE, E. L, KEIM, E. R, GAO, R. S

“…Simultaneous in situ measurements of the concentrations of OH, HO(2), ClO, BrO, NO, and NO(2) demonstrate the predominance of odd-hydrogen and halogen…”
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The observation of nitric acid-containing particles in the tropical lower stratosphere by Popp, P. J., Marcy, T. P., Jensen, E. J., Kärcher, B., Fahey, D. W., Gao, R. S., Thompson, T. L., Rosenlof, K. H., Richard, E. C., Herman, R. L., Weinstock, E. M., Smith, J. B., May, R. D., Vömel, H., Wilson, J. C., Heymsfield, A. J., Mahoney, M. J., Thompson, A. M.

“…Airborne in situ measurements over the eastern Pacific Ocean in January 2004 have revealed a new category of nitric acid (HNO3)-containing particles in the…”
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Emission measurements of the Concorde supersonic aircraft in the lower stratosphere by Fahey, D.W. (NOAA, Boulder, CO.), Keim, E.R, Boering, K.A, Brock, C.A, Wilson, J.C, Jonsson, H.H, Anthony, S, Hanisco, T.F, Wennberg, P.O, Miake-Lye, R.C

“…Emission indices of reactive gases and particles were determined from measurements in the exhaust plume of a Concorde aircraft cruising at supersonic speeds in…”
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Chlorine Chemistry on Polar Stratospheric Cloud Particles in the Arctic Winter by Webster, C. R., May, R. D., Toohey, D. W., Avallone, L. M., Anderson, J. G., Newman, P., Lait, L., Schoeberl, M. R., Elkins, J. W., Chan, K. R.

“…Simultaneous in situ measurements of hydrochloric acid (HCl) and chlorine monoxide (ClO) in the Arctic winter vortex showed large HCl losses, of up to 1 part…”
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An examination of chemistry and transport processes in the tropical lower stratosphere using observations of long-lived and short-lived compounds obtained during STRAT and POLARIS by Flocke, F., Herman, R. L., Salawitch, R. J., Atlas, E., Webster, C. R., Schauffler, S. M., Lueb, R. A., May, R. D., Moyer, E. J., Rosenlof, K. H., Scott, D. C., Blake, D. R., Bui, T. P.

“…A suite of compounds with a wide range of photochemical lifetimes (3 months to several decades) was measured in the tropical and midlatitude upper troposphere…”
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Comparison of MkIV balloon and ER-2 aircraft measurements of atmospheric trace gases by Toon, G. C., Blavier, J.‐F., Sen, B., Margitan, J. J., Webster, C. R., May, R. D., Fahey, D., Gao, R., Del Negro, L., Proffitt, M., Elkins, J., Romashkin, P. A., Hurst, D. F., Oltmans, S., Atlas, E., Schauffler, S., Flocke, F., Bui, T. P., Stimpfle, R. M., Bonne, G. P., Voss, P. B., Cohen, R. C.

“…On May 8, 1997, vertical profiles of over 30 different gases were measured remotely in solar occultation by the Jet Propulsion Laboratory MkIV Interferometer…”
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Procedural Justice Explanations and Employee Reactions to Economic Hardship: A Field Experiment by Schaubroeck, John, May, Douglas R, Brown, F. William

“…In a randomized field experiment involving 173 salaried employees, treatment subjects received an explanation for an ongoing pay freeze. This explained the…”
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Subsidence, mixing, and denitrification of Arctic polar vortex air measured during POLARIS by Rex, M., Salawitch, R. J., Toon, G. C., Sen, B., Margitan, J. J., Osterman, G. B., Blavier, J.‐F., Gao, R. S., Donnelly, S., Keim, E., Neuman, J., Fahey, D. W., Webster, C. R., Scott, D. C., Herman, R. L., May, R. D., Moyer, E. J., Gunson, M. R., Irion, F. W., Chang, A. Y., Rinsland, C. P., Bui, T. P.

“…We determine the degree of denitrification that occurred during the 1996–1997 Arctic winter using a technique that is based on balloon and aircraft borne…”
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Tropical entrainment time scales inferred from stratospheric N2O and CH4 observations by Herman, R. L., Scott, D. C., Webster, C. R., May, R. D., Moyer, E. J., Salawitch, R. J., Yung, Y. L., Toon, G. C., Sen, B., Margitan, J. J., Rosenlof, K. H., Michelsen, H. A., Elkins, J. W.

“…Simultaneous in situ measurements of N2O and CH4 were made with a tunable diode laser spectrometer (ALIAS II) aboard the Observations from the Middle…”
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Distinct roles for S100a8 in early embryo development and in the maternal deciduum by Baker, J.R., Jeffery, R., May, R.D., Mathies, M., Spencer‐Dene, B., Poulsom, R., Hogg, N.

“…S100a8 is a cytosolic protein expressed in myeloid cells where it forms a stable heterodimer with another S100 protein family member, S100a9. The S100a9−/−…”
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