Search Results - "Maxwell, Taylor J"

Quantitative trait loci, G×E and G×G for glycemic traits: response to metformin and placebo in the Diabetes Prevention Program (DPP) by Maxwell, Taylor J, Franks, Paul W, Kahn, Steven E, Knowler, William C, Mather, Kieren J, Florez, Jose C, Jablonski, Kathleen A

“…The complex genetic architecture of type-2-diabetes (T2D) includes gene-by-environment (G×E) and gene-by-gene (G×G) interactions. To identify G×E and G×G, we…”
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A Family‐Based Joint Test for Mean and Variance Heterogeneity for Quantitative Traits by Cao, Ying, Maxwell, Taylor J., Wei, Peng

“…Summary Traditional quantitative trait locus (QTL) analysis focuses on identifying loci associated with mean heterogeneity. Recent research has discovered loci…”
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Genome-wide association study for variants that modulate relationships between cerebrospinal fluid amyloid-beta 42, tau, and p-tau levels by Maxwell, Taylor J, Corcoran, Chris, Del-Aguila, Jorge L, Budde, John P, Deming, Yuetiva, Cruchaga, Carlos, Goate, Alison M, Kauwe, John S K

“…A relationship quantitative trait locus exists when the correlation between multiple traits varies by genotype for that locus. Relationship quantitative trait…”
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Mitochondrial genomic analysis of late onset Alzheimer's disease reveals protective haplogroups H6A1A/H6A1B: the Cache County Study on Memory in Aging by Ridge, Perry G, Maxwell, Taylor J, Corcoran, Christopher D, Norton, Maria C, Tschanz, Joann T, O'Brien, Elizabeth, Kerber, Richard A, Cawthon, Richard M, Munger, Ronald G, Kauwe, John S K

“…Alzheimer's disease (AD) is the most common cause of dementia and AD risk clusters within families. Part of the familial aggregation of AD is accounted for by…”
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Mitochondrial haplotypes associated with biomarkers for Alzheimer's disease by Ridge, Perry G, Koop, Andre, Maxwell, Taylor J, Bailey, Matthew H, Swerdlow, Russell H, Kauwe, John S K, Honea, Robyn A

“…Various studies have suggested that the mitochondrial genome plays a role in late-onset Alzheimer's disease, although results are mixed. We used an…”
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Phylogenetics applied to genotype/phenotype association and selection analyses with sequence data from angptl4 in humans by Maxwell, Taylor J, Bendall, Matthew L, Staples, Jeffrey, Jarvis, Todd, Crandall, Keith A

“…Genotype/phenotype association analyses (Treescan) with plasma lipid levels and functional site prediction methods (TreeSAAP and PolyPhen) were performed using…”
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RQTL THAT AFFECT THE RELATIONSHIP BETWEEN Aß42, TAU AND PTAU, AND LOCI THAT INTERACT WITH THEM (GXG) by Maxwell, Taylor J, Kauwe, Keoni, Corcoran, Christopher

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Deep resequencing reveals excess rare recent variants consistent with explosive population growth by Coventry, Alex, Bull-Otterson, Lara M, Liu, Xiaoming, Clark, Andrew G, Maxwell, Taylor J, Crosby, Jacy, Hixson, James E, Rea, Thomas J, Muzny, Donna M, Lewis, Lora R, Wheeler, David A, Sabo, Aniko, Lusk, Christine, Weiss, Kenneth G, Akbar, Humeira, Cree, Andrew, Hawes, Alicia C, Newsham, Irene, Varghese, Robin T, Villasana, Donna, Gross, Shannon, Joshi, Vandita, Santibanez, Jireh, Morgan, Margaret, Chang, Kyle, IV, Walker Hale, Templeton, Alan R, Boerwinkle, Eric, Gibbs, Richard, Sing, Charles F

“…Accurately determining the distribution of rare variants is an important goal of human genetics, but resequencing of a sample large enough for this purpose has…”
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A Versatile Omnibus Test for Detecting Mean and Variance Heterogeneity by Cao, Ying, Wei, Peng, Bailey, Matthew, Kauwe, John S. K., Maxwell, Taylor J.

“…ABSTRACT Recent research has revealed loci that display variance heterogeneity through various means such as biological disruption, linkage disequilibrium…”
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Correction to: Quantitative trait loci, G×E and G×G for glycemic traits: response to metformin and placebo in the Diabetes Prevention Program (DPP) by Maxwell, Taylor J, Franks, Paul W, Kahn, Steven E, Knowler, William C, Mather, Kieren J, Florez, Jose C, Jablonski, Kathleen A

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APOE modulates the correlation between triglycerides, cholesterol, and CHD through pleiotropy, and gene-by-gene interactions by Maxwell, Taylor J, Ballantyne, Christie M, Cheverud, James M, Guild, Cameron S, Ndumele, Chiadi E, Boerwinkle, Eric

“…Relationship loci (rQTL) exist when the correlation between multiple traits varies by genotype. rQTL often occur due to gene-by-gene (G × G) or…”
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Estimating population genetic parameters and comparing model goodness-of-fit using DNA sequences with error by Liu, Xiaoming, Fu, Yun-Xin, Maxwell, Taylor J, Boerwinkle, Eric

“…It is known that sequencing error can bias estimation of evolutionary or population genetic parameters. This problem is more prominent in deep resequencing…”
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DAPK1 variants are associated with Alzheimer's disease and allele-specific expression by Li, Yonghong, Grupe, Andrew, Rowland, Charles, Nowotny, Petra, Kauwe, John S.K., Smemo, Scott, Hinrichs, Anthony, Tacey, Kristina, Toombs, Timothy A., Kwok, Shirley, Catanese, Joseph, White, Thomas J., Maxwell, Taylor J., Hollingworth, Paul, Abraham, Richard, Rubinsztein, David C., Brayne, Carol, Wavrant-De Vrièze, Fabienne, Hardy, John, O'Donovan, Michael, Lovestone, Simon, Morris, John C., Thal, Leon J., Owen, Michael, Williams, Julie, Goate, Alison

“…Genetic factors play an important role in the etiology of late-onset Alzheimer's disease (LOAD). We tested gene-centric single nucleotide polymorphisms (SNPs)…”
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Diet-Dependent Genetic and Genomic Imprinting Effects on Obesity in Mice by Cheverud, James M., Lawson, Heather A., Fawcett, Gloria L., Wang, Bing, Pletscher, L. Susan, Fox, Ashley R., Maxwell, Taylor J., Ehrich, Thomas H., Kenney‐Hunt, Jane P., Wolf, Jason B., Semenkovich, Clay F.

“…Although the current obesity epidemic is of environmental origin, there is substantial genetic variation in individual response to an obesogenic environment…”
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A Scan of Chromosome 10 Identifies a Novel Locus Showing Strong Association with Late-Onset Alzheimer Disease by Grupe, Andrew, Li, Yonghong, Rowland, Charles, Nowotny, Petra, Hinrichs, Anthony L., Smemo, Scott, Kauwe, John S.K., Maxwell, Taylor J., Cherny, Sara, Doil, Lisa, Tacey, Kristina, van Luchene, Ryan, Myers, Amanda, Wavrant-De Vrièze, Fabienne, Kaleem, Mona, Hollingworth, Paul, Jehu, Luke, Foy, Catherine, Archer, Nicola, Hamilton, Gillian, Holmans, Peter, Morris, Chris M., Catanese, Joseph, Sninsky, John, White, Thomas J., Powell, John, Hardy, John, O’Donovan, Michael, Lovestone, Simon, Jones, Lesley, Morris, John C., Thal, Leon, Owen, Michael, Williams, Julie, Goate, Alison

“…Strong evidence of linkage to late-onset Alzheimer disease (LOAD) has been observed on chromosome 10, which implicates a wide region and at least one…”
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Mitochondrial genomic variation associated with higher mitochondrial copy number: the Cache County Study on Memory Health and Aging by Ridge, Perry G, Maxwell, Taylor J, Foutz, Spencer J, Bailey, Matthew H, Corcoran, Christopher D, Tschanz, JoAnn T, Norton, Maria C, Munger, Ronald G, O'Brien, Elizabeth, Kerber, Richard A, Cawthon, Richard M, Kauwe, John S K

“…The mitochondria are essential organelles and are the location of cellular respiration, which is responsible for the majority of ATP production. Each cell…”
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Genome changes after gene duplication: haploidy vs. diploidy by Xue, Cheng, Huang, Ren, Maxwell, Taylor J, Fu, Yun-Xin

“…Since genome size and the number of duplicate genes observed in genomes increase from haploid to diploid organisms, diploidy might provide more evolutionary…”
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Genetic, epigenetic, and gene-by-diet interaction effects underlie variation in serum lipids in a LG/JxSM/J murine model by Lawson, Heather A, Zelle, Kathleen M, Fawcett, Gloria L, Wang, Bing, Pletscher, L. Susan, Maxwell, Taylor J, Ehrich, Thomas H, Kenney-Hunt, Jane P, Wolf, Jason B, Semenkovich, Clay F, Cheverud, James M

“…Variation in serum cholesterol, free-fatty acids, and triglycerides is associated with cardiovascular disease (CVD) risk factors. There is great interest in…”
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The importance of context to the genetic architecture of diabetes-related traits is revealed in a genome-wide scan of a LG/J × SM/J murine model by Lawson, Heather A., Lee, Arthur, Fawcett, Gloria L., Wang, Bing, Pletscher, L. Susan, Maxwell, Taylor J., Ehrich, Thomas H., Kenney-Hunt, Jane P., Wolf, Jason B., Semenkovich, Clay F., Cheverud, James M.

“…Variations in diabetic phenotypes are caused by complex interactions of genetic effects, environmental factors, and the interplay between the two. We tease…”
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Replication of long-bone length QTL in the F₉-F₁₀ LG,SM advanced intercross by Norgard, Elizabeth A, Jarvis, Joseph P, Roseman, Charles C, Maxwell, Taylor J, Kenney-Hunt, Jane P, Samocha, Kaitlin E, Pletscher, L. Susan, Wang, Bing, Fawcett, Gloria L, Leatherwood, Christopher J, Wolf, Jason B, Cheverud, James M

“…Quantitative trait locus (QTL) mapping techniques are frequently used to identify genomic regions associated with variation in phenotypes of interest. However,…”
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