Dysregulated serum concentrations of fat‐soluble vitamins in dogs with chronic enteropathy

Background In inflammatory bowel disease (IBD) of humans, nutrient malabsorption can result in fat‐soluble vitamin deficiency, especially of vitamin D. In veterinary species, decreased concentrations of vitamin D are relatively common in dogs with chronic enteropathy (CE), but data on the status of...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of veterinary internal medicine Vol. 38; no. 5; pp. 2612 - 2619
Main Authors:	Serafini, Federica, Maxwell, Kristen M., Zhu, Xiaojuan, Lennon, Elizabeth M.
Format:	Journal Article
Language:	English
Published:	Hoboken, USA John Wiley & Sons, Inc 01-09-2024 Wiley
Subjects:	Abdomen alpha-Tocopherol - blood Animals Biochemistry Case-Control Studies Chromatography Chronic Disease - veterinary Cytokines Diet Dog Diseases - blood Dogs Feces Female Hormones Inflammation Inflammatory bowel disease Intestinal Diseases - blood Intestinal Diseases - veterinary Laboratories Male retinol SMALL ANIMAL Veterinary medicine Vitamin A Vitamin A - blood Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood Vitamin deficiency vitamins D α‐tocopherol United States > US Michigan retinol vitamins D α‐tocopherol inflammatory bowel disease
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Background In inflammatory bowel disease (IBD) of humans, nutrient malabsorption can result in fat‐soluble vitamin deficiency, especially of vitamin D. In veterinary species, decreased concentrations of vitamin D are relatively common in dogs with chronic enteropathy (CE), but data on the status of other fat‐soluble vitamins (FSVs) is lacking. Objectives Determine the serum concentrations of retinol, vitamin D, and α‐tocopherol in dogs with CE compared with healthy dogs and compare clinical, clinicopathologic variables between CE and healthy dogs to detect associations with decreased FSVs concentrations. Animals Eighteen client‐owned dogs with CE and 33 healthy dogs. Methods Serum 25‐hydroxyvitamin D (25[OH]D), serum retinol and α‐tocopherol concentrations were compared between groups. Correlations and multiple regression modeling were used to examine the relationship between serum 25(OH)D, retinol, and α‐tocopherol concentrations and clinical and clinicopathological variables. Results Dogs with low serum albumin concentrations were more likely to have lower 25(OH)D concentrations than dogs with normal serum albumin concentration. Dogs with CE had higher serum concentrations of retinol, and variable α‐tocopherol concentrations. The cause of these dysregulated vitamin concentrations is unclear and requires further study. Conclusion and Clinical Importance Dogs with severe forms of CE should be monitored for decreased concentrations of 25(OH)D. Additional studies are needed to evaluate the clinical relevance and the possible benefit of vitamin D supplementation in these patients.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0891-6640 1939-1676 1939-1676
DOI:	10.1111/jvim.17107