Search Results - "Maxwell, KN"

Adenoviral-Mediated Expression of Pcsk9 in Mice Results in a Low-Density Lipoprotein Receptor Knockout Phenotype by Maxwell, Kara N., Breslow, Jan L.

“…Proprotein convertase subtilisin kexin 9 (Pcsk9) is a subtilisin serine protease with a putative role in cholesterol metabolism. Pcsk9 expression is…”
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Bile Acids Modulate Signaling by Functional Perturbation of Plasma Membrane Domains by Zhou, Yong, Maxwell, Kelsey N., Sezgin, Erdinc, Lu, Maryia, Liang, Hong, Hancock, John F., Dial, Elizabeth J., Lichtenberger, Lenard M., Levental, Ilya

“…Eukaryotic cell membranes are organized into functional lipid and protein domains, the most widely studied being membrane rafts. Although rafts have been…”
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Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment by Maxwell, K.N, Fisher, E.A, Breslow, J.L

“…Proprotein convertase subtilisin kexin 9 (PCSK9) is a member of the subtilisin serine protease family with an important role in cholesterol metabolism. PCSK9…”
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Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice by Maxwell, Kara N., Soccio, Raymond E., Duncan, Elizabeth M., Sehayek, Ephraim, Breslow, Jan L.

“…High-cholesterol diets elicit changes in gene expression via such transcription factors as sterol-regulatory element binding proteins (SREBPs) and liver X…”
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Abstract P5-10-04: Spectrum of hereditary breast and ovarian cancer gene variants in an African American cohort by Shah, PD, Digiovanni, L, Maxwell, KN, Bradbury, AR, Van Den Akker, J, Kim, S, Gil, E, Simon, MS, Nathanson, KL, Domchek, SM

“…Abstract Background: Few reports describe the spectrum of mutations in breast and ovarian cancer predisposition genes found specifically in African Americans…”
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Abstract OT2-06-03: METAMORPH: METAstatic markers of recurrent tumor PHenotype for breast cancer by DeMichele, A, Soucier-Ernst, DJ, Clark, C, Shih, N, Stavropoulos, W, Maxwell, KN, Feldman, M, Lierbamen, D, Morrissette, JJD, Paul, MR, Pan, T-C, Wang, J, Belka, GK, Chen, Y, Yee, S, Carpenter, E, Fox, K, Matro, J, Clark, A, Shah, P, Domchek, S, Bradbury, A, Chodosh, L

“…Abstract Up to 30% of patients diagnosed with breast cancer will develop recurrent disease within their lifetime, and currently this form of the disease is…”
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Abstract PD4-07: PET imaging of PARP-1 expression in breast cancer by McDonald, ES, Carlin, S, Maxwell, KN, Nayak, A, Doot, RK, Pantel, AR, Farwell, MD, Pryma, DA, Clark, AS, Shah, P, DeMichele, AM, Ziober, A, Schubert, EK, Palmer, K, Lee, HS, Matro, J, de la Cruz, L, Tchou, J, Anderson, DN, Feldman, MD, Sheffer, RE, Knollman, H, Schnall, MD, Makvandi, M, Domchek, S, Hubbard, RA, Mach, RH, Mankoff, DA

“…Abstract 18F-FluorThanatrace ([18F]-FTT) is a novel radiotracer shown to quantify Poly [ADP-ribose] polymerase 1 (PARP-1) expression in vitro and in vivo…”
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Abstract P2-09-01: Patient reported outcomes of multiplex breast cancer susceptibility testing utilizing a tiered-binned counseling and informed consent model in BRCA1/2 negative patients by Bradbury, AR, Patrick-Miller, L, Egleston, BE, Maxwell, KN, Brandt, A, Brower, J, DiGiovanni, L, Long, JM, Powers, J, Stopfer, J, Nathanson, KL, Domchek, SM

“…Abstract Background:The risks, benefits and utilities of multiplex panels for breast cancer susceptibility are unknown and new counseling and informed consent…”
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Differential gene regulation of StarD4 and StarD5 cholesterol transfer proteins. Activation of StarD4 by sterol regulatory element-binding protein-2 and StarD5 by endoplasmic reticulum stress by Soccio, Raymond E, Adams, Rachel M, Maxwell, Kara N, Breslow, Jan L

“…The StarD4 and StarD5 proteins share approximately 30% identity, and each is a steroidogenic acute regulatory protein (StAR)-related lipid transfer (START)…”
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Abstract P6-07-05: Mutational spectrum and tumor response in metastatic breast cancer by Soucier-Ernst, D, Colameco, C, Troxel, AB, Clark, C, Shih, N, Maxwell, KN, Morrissette, J, Lieberman, D, Feldman, M, Goodman, N, Bradbury, A, Clark, A, Domchek, S, Fox, K, Glick, J, Matro, J, Nathanson, K, Chodosh, L, DeMichele, A

“…Abstract Background: While several comprehensive genomic sequencing tests are clinically available for breast cancer(BC), little is known about the spectrum of…”
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Proprotein convertase subtilisin kexin 9: the third locus implicated in autosomal dominant hypercholesterolemia by Maxwell, Kara N, Breslow, Jan L

“…Autosomal dominant hypercholesterolemia is a genetic disease in which patients have elevated LDL cholesterol levels and premature atherosclerosis. Mutations in…”
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The spd-2 gene is required for polarization of the anteroposterior axis and formation of the sperm asters in the Caenorhabditis elegans zygote by O'Connell, Kevin Fe, Maxwell, Kara N., White, John O.

“…In the Caenorhabditis elegans zygote, polarization of the anteroposterior (AP) axis occurs during a brief period of reorganization that follows fertilization…”
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ABO Blood Groups and Hypertension by Maxwell, Roy D. H., Maxwell, Katharine N.

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