Search Results - "Max, Klaas E. A"

Cell and Microvesicle Urine microRNA Deep Sequencing Profiles from Healthy Individuals: Observations with Potential Impact on Biomarker Studies by Ben-Dov, Iddo Z, Whalen, Veronica M, Goilav, Beatrice, Max, Klaas E A, Tuschl, Thomas

“…Urine is a potential source of biomarkers for diseases of the kidneys and urinary tract. RNA, including microRNA, is present in the urine enclosed in detached…”
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The Coxsackievirus-Adenovirus Receptor Reveals Complex Homophilic and Heterophilic Interactions on Neural Cells by Patzke, Christopher, Max, Klaas E. A, Behlke, Joachim, Schreiber, Jadwiga, Schmidt, Hannes, Dorner, Armin A, Kroger, Stephan, Henning, Mechthild, Otto, Albrecht, Heinemann, Udo, Rathjen, Fritz G

“…The coxsackievirus-adenovirus receptor (CAR) is a member of the Ig superfamily strongly expressed in the developing nervous system. Our histological…”
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Urine cell-free microRNA as biomarkers for transitional cell carcinoma by Geva, Gil A, Gielchinsky, Ilan, Aviv, Nina, Max, Klaas E A, Gofrit, Ofer N, Gur-Wahnon, Devorah, Ben-Dov, Iddo Z

“…MicroRNA (miRNA) are short nucleotide strands with a regulatory function in the cell. Several miRNAs have been shown to be useful as biomarkers for different…”
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Plasma microRNA Interindividual Variability in Healthy Individuals, Pregnant Women, and an Individual with a Stably Altered Neuroendocrine Phenotype by Max, Klaas E.A., Wang, Victoria R., Chang, Michael S., Liau, Jonathan, Weiss, Zachary R., Morgan, Stephanie, Li, Jenny, Bogardus, Kimberly A., Morozov, Pavel, Suryawanshi, Hemant, Akat, Kemal M., Ben-Dov, Iddo Z., Hurley, Arlene M., Dowd, Kathleen, Williams, Zev, Tuschl, Thomas

“…Abstract Background Extracellular RNAs (exRNAs) in biofluids are amenable to quantitative analysis and proposed as noninvasive biomarkers for monitoring organ…”
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RNA single strands bind to a conserved surface of the major cold shock protein in crystals and solution by Sachs, Rolf, Max, Klaas E A, Heinemann, Udo, Balbach, Jochen

“…Bacterial cold shock proteins (CSPs) regulate the cellular response to temperature downshift. Their general principle of function involves RNA chaperoning and…”
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Open Problems in Extracellular RNA Data Analysis: Insights From an ERCC Online Workshop by Alexander, Roger P, Kitchen, Robert R, Tosar, Juan Pablo, Roth, Matthew, Mestdagh, Pieter, Max, Klaas E A, Rozowsky, Joel, Kaczor-Urbanowicz, Karolina Elżbieta, Chang, Justin, Balaj, Leonora, Losic, Bojan, Van Nostrand, Eric L, LaPlante, Emily, Mateescu, Bogdan, White, Brian S, Yu, Rongshan, Milosavljevic, Aleksander, Stolovitzky, Gustavo, Spengler, Ryan M

“…We now know RNA can survive the harsh environment of biofluids when encapsulated in vesicles or by associating with lipoproteins or RNA binding proteins. These…”
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Sequence specificity of single-stranded DNA-binding proteins: a novel DNA microarray approach by Morgan, Hugh P, Estibeiro, Peter, Wear, Martin A, Max, Klaas E.A, Heinemann, Udo, Cubeddu, Liza, Gallagher, Maurice P, Sadler, Peter J, Walkinshaw, Malcolm D

“…We have developed a novel DNA microarray-based approach for identification of the sequence-specificity of single-stranded nucleic-acid-binding proteins…”
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Sequential development of several RT‐qPCR tests using LNA nucleotides and dual probe technology to differentiate SARS‐CoV‐2 from influenza A and B by Radvánszka, Monika, Paul, Evan D., Hajdu, Roman, Boršová, Kristína, Kováčová, Viera, Putaj, Piotr, Bírová, Stanislava, Čirková, Ivana, Čarnecký, Martin, Buranovská, Katarína, Szobi, Adrián, Vojtaššáková, Nina, Drobná, Diana, Čabanová, Viktória, Sláviková, Monika, Ličková, Martina, Vaňová, Veronika, Fumačová Havlíková, Sabína, Lukáčiková, Ľubomíra, Kajanová, Ivana, Koči, Juraj, Rusňáková, Diana, Sedláčková, Tatiana, Max, Klaas E. A., Tuschl, Thomas, Szemes, Tomáš, Klempa, Boris, Čekan, Pavol

“…Summary Sensitive and accurate RT‐qPCR tests are the primary diagnostic tools to identify SARS‐CoV‐2‐infected patients. While many SARS‐CoV‐2 RT‐qPCR tests are…”
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A single-cell survey of the human first-trimester placenta and decidua by Suryawanshi, Hemant, Morozov, Pavel, Straus, Alexander, Sahasrabudhe, Nicole, Max, Klaas E A, Garzia, Aitor, Kustagi, Manjunath, Tuschl, Thomas, Williams, Zev

“…The placenta and decidua interact dynamically to enable embryonic and fetal development. Here, we report single-cell RNA sequencing of 14,341 and 6754 cells…”
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Human plasma and serum extracellular small RNA reference profiles and their clinical utility by Max, Klaas E. A., Bertram, Karl, Akat, Kemal Marc, Bogardus, Kimberly A., Li, Jenny, Morozov, Pavel, Ben-Dov, Iddo Z., Li, Xin, Weiss, Zachary R., Azizian, Azadeh, Sopeyin, Anuoluwapo, Diacovo, Thomas G., Adamidi, Catherine, Williams, Zev, Tuschl, Thomas

“…Circulating extracellular RNAs (exRNAs) have the potential to serve as biomarkers for a wide range of medical conditions. However, limitations in existing…”
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Recognition of T-rich single-stranded DNA by the cold shock protein Bs-CspB in solution by Zeeb, Markus, Max, Klaas E A, Weininger, Ulrich, Löw, Christian, Sticht, Heinrich, Balbach, Jochen

“…Cold shock proteins (CSP) belong to the family of single-stranded nucleic acid binding proteins with OB-fold. CSP are believed to function as 'RNA chaperones'…”
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Identification of mRNAs bound and regulated by human LIN28 proteins and molecular requirements for RNA recognition by Hafner, Markus, Max, Klaas E A, Bandaru, Pradeep, Morozov, Pavel, Gerstberger, Stefanie, Brown, Miguel, Molina, Henrik, Tuschl, Thomas

“…Human LIN28A and LIN28B are RNA-binding proteins (RBPs) conserved in animals with important roles during development and stem cell reprogramming. We used…”
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Identification of the RNA recognition element of the RBPMS family of RNA-binding proteins and their transcriptome-wide mRNA targets by Farazi, Thalia A, Leonhardt, Carl S, Mukherjee, Neelanjan, Mihailovic, Aleksandra, Li, Song, Max, Klaas E A, Meyer, Cindy, Yamaji, Masashi, Cekan, Pavol, Jacobs, Nicholas C, Gerstberger, Stefanie, Bognanni, Claudia, Larsson, Erik, Ohler, Uwe, Tuschl, Thomas

“…Recent studies implicated the RNA-binding protein with multiple splicing (RBPMS) family of proteins in oocyte, retinal ganglion cell, heart, and…”
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Common mode of DNA binding to cold shock domains by Max, Klaas E. A., Zeeb, Markus, Bienert, Ralf, Balbach, Jochen, Heinemann, Udo

“…Bacterial cold shock proteins (CSPs) regulate cellular adaptation to cold stress. Functions ascribed to CSP include roles as RNA chaperones and in…”
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Common mode of DNA binding to cold shock domains. Crystal structure of hexathymidine bound to the domain-swapped form of a major cold shock protein from Bacillus caldolyticus by Max, Klaas E A, Zeeb, Markus, Bienert, Ralf, Balbach, Jochen, Heinemann, Udo

“…Bacterial cold shock proteins (CSPs) regulate cellular adaptation to cold stress. Functions ascribed to CSP include roles as RNA chaperones and in…”
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Characterizing and classifying neuroendocrine neoplasms through microRNA sequencing and data mining by Nanayakkara, Jina, Tyryshkin, Kathrin, Yang, Xiaojing, Wong, Justin J M, Vanderbeck, Kaitlin, Ginter, Paula S, Scognamiglio, Theresa, Chen, Yao-Tseng, Panarelli, Nicole, Cheung, Nai-Kong, Dijk, Frederike, Ben-Dov, Iddo Z, Kim, Michelle Kang, Singh, Simron, Morozov, Pavel, Max, Klaas E A, Tuschl, Thomas, Renwick, Neil

“…Abstract Neuroendocrine neoplasms (NENs) are clinically diverse and incompletely characterized cancers that are challenging to classify. MicroRNAs (miRNAs) are…”
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T-rich DNA Single Strands Bind to a Preformed Site on the Bacterial Cold Shock Protein Bs-CspB by Max, Klaas E.A., Zeeb, Markus, Bienert, Ralf, Balbach, Jochen, Heinemann, Udo

“…Bacterial cold shock proteins (CSPs) are involved in cellular adaptation to cold stress. They bind to single-stranded nucleic acids with a K D value in the…”
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Optimized Variants of the Cold Shock Protein from in Vitro Selection: Structural Basis of Their High Thermostability by Max, Klaas E.A., Wunderlich, Michael, Roske, Yvette, Schmid, Franz X., Heinemann, Udo

“…The bacterial cold shock proteins (Csp) are widely used as models for the experimental and computational analysis of protein stability. In a previous study, in…”
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The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research by Das, Saumya, Abdel-Mageed, Asim B., Adelson, P. David, Akat, Kemal M., Alsop, Eric, Azizian, Azadeh, Balaj, Leonora, Ben-Dov, Iddo Z., Bertram, Karl, Blelloch, Robert, Charest, Al, Chen, Clark C., Coffey, Robert J., Courtright-Lim, Amanda, Das, Saumya, Datta, Amrita, Ferrer, Marc, Galas, David J., Galeev, Timur, Gandhi, Roopali, Garcia, Aitor, Ghiran, Ionita Calin, Giraldez, Maria D., Goga, Andrei, Gogakos, Tasos, Goilav, Beatrice, Gould, Stephen J., Guo, Peixuan, Gupta, Mihir, Hochberg, Fred, Hunter, Craig, Hutchins, Elizabeth, Kalani, M. Yashar S., Kanlikilicer, Pinar, Karaszti, Reka Agnes, Kim, Yong, Kim, Hogyoung, Kitchen, Robert, Krichevsky, Anna M., Kwong, Raymond Y., Laurent, Louise C., L’Etoile, Noelle, Li, Feng, Li, Jenny, Li, Xin, Lucero, Rocco, Mateescu, Bogdan, Matin, A.C., Max, Klaas E.A., McManus, Michael T., Mempel, Thorsten R., Meyer, Cindy, Milosavljevic, Aleksandar, Mondal, Debasis, Mukamal, Kenneth Jay, Murillo, Oscar D., Muthukumar, Thangamani, Nickerson, Deborah A., Patel, Dinshaw J., Patton, James G., Paul, Anu, Peskind, Elaine R., Phelps, Mitch A., Ranabothu, Saritha, Rodriguez-Aguayo, Cristian, Rosenzweig, Anthony, Roth, Matthew E., Schmittgen, Thomas D., Shah, Neethu, Shah, Ravi, Shedden, Kerby, Shi, Jian, Sood, Anil K., Sopeyin, Anuoluwapo, Spengler, Ryan M., Spetzler, Robert, Subramanian, Sai Lakshmi, Teng, Yun, Thistlethwaite, William, Vickers, Kasey C., Voinnet, Olivier, Weaver, Alissa M., Wei, Zhiyun, Weiner, Howard L., Weiss, Zachary R., Wong, David T.W., Woodruff, Prescott G., Yan, Irene K., Yeri, Ashish, Zhang, Bing, Bitzer, Markus, Breakefield, Xandra O., Charest, Alain, Gupta, Mihir, Milosavljevic, Aleksandar, McManus, Michael T., Roth, Matthew E., Saugstad, Julie A., Van Keuren-Jensen, Kendall, Weaver, Alissa M.

“…The Extracellular RNA Communication Consortium (ERCC) was launched to accelerate progress in the new field of extracellular RNA (exRNA) biology and to…”
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Optimization of the G beta 1 Domain by Computational Design and by in Vitro Evolution: Structural and Energetic Basis of Stabilization by Wunderlich, M, Max, KEA, Roske, Y, Mueller, U, Heinemann, U, Schmid, F X

“…Computational design and in vitro evolution are major strategies for stabilizing proteins. For the four critical positions 16, 18, 25, and 29 of the B domain…”
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