Search Results - "Mawuenyega, Kwasi G"

Age and amyloid effects on human central nervous system amyloid-beta kinetics by Patterson, Bruce W., Elbert, Donald L., Mawuenyega, Kwasi G., Kasten, Tom, Ovod, Vitaliy, Ma, Shengmei, Xiong, Chengjie, Chott, Robert, Yarasheski, Kevin, Sigurdson, Wendy, Zhang, Lily, Goate, Alison, Benzinger, Tammie, Morris, John C., Holtzman, David, Bateman, Randall J.

“…Objective Age is the single greatest risk factor for Alzheimer's disease (AD), with the incidence doubling every 5 years after age 65. However, our…”
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In vivo human apolipoprotein E isoform fractional turnover rates in the CNS by Wildsmith, Kristin R, Basak, Jacob M, Patterson, Bruce W, Pyatkivskyy, Yuriy, Kim, Jungsu, Yarasheski, Kevin E, Wang, Jennifer X, Mawuenyega, Kwasi G, Jiang, Hong, Parsadanian, Maia, Yoon, Hyejin, Kasten, Tom, Sigurdson, Wendy C, Xiong, Chengjie, Goate, Alison, Holtzman, David M, Bateman, Randall J

“…Apolipoprotein E (ApoE) is the strongest genetic risk factor for Alzheimer's disease and has been implicated in the risk for other neurological disorders. The…”
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Amyloid-β Plaques in Clinical Alzheimer's Disease Brain Incorporate Stable Isotope Tracer In Vivo and Exhibit Nanoscale Heterogeneity by Wildburger, Norelle C, Gyngard, Frank, Guillermier, Christelle, Patterson, Bruce W, Elbert, Donald, Mawuenyega, Kwasi G, Schneider, Theresa, Green, Karen, Roth, Robyn, Schmidt, Robert E, Cairns, Nigel J, Benzinger, Tammie L S, Steinhauser, Matthew L, Bateman, Randall J

“…Alzheimer's disease (AD) is a neurodegenerative disorder with clinical manifestations of progressive memory decline and loss of executive function and…”
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High-precision plasma β-amyloid 42/40 predicts current and future brain amyloidosis by Schindler, Suzanne E, Bollinger, James G, Ovod, Vitaliy, Mawuenyega, Kwasi G, Li, Yan, Gordon, Brian A, Holtzman, David M, Morris, John C, Benzinger, Tammie L.S, Xiong, Chengjie, Fagan, Anne M, Bateman, Randall J

“…OBJECTIVEWe examined whether plasma β-amyloid (Aβ)42/Aβ40, as measured by a high-precision assay, accurately diagnosed brain amyloidosis using amyloid PET or…”
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Decreased Clearance of CNS β-Amyloid in Alzheimer's Disease by Mawuenyega, Kwasi G, Sigurdson, Wendy, Ovod, Vitaliy, Munsell, Ling, Kasten, Tom, Morris, John C, Yarasheski, Kevin E, Bateman, Randall J

“…Alzheimer's disease is hypothesized to be caused by an imbalance between β-amyloid (Aβ) production and clearance that leads to Aβ accumulation in the central…”
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Effect of sleep on overnight cerebrospinal fluid amyloid β kinetics by Lucey, Brendan P., Hicks, Terry J., McLeland, Jennifer S., Toedebusch, Cristina D., Boyd, Jill, Elbert, Donald L., Patterson, Bruce W., Baty, Jack, Morris, John C., Ovod, Vitaliy, Mawuenyega, Kwasi G., Bateman, Randall J.

“…Sleep disturbances are associated with future risk of Alzheimer disease. Disrupted sleep increases soluble amyloid β, suggesting a mechanism for sleep…”
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Amyloid β concentrations and stable isotope labeling kinetics of human plasma specific to central nervous system amyloidosis by Ovod, Vitaliy, Ramsey, Kara N., Mawuenyega, Kwasi G., Bollinger, Jim G., Hicks, Terry, Schneider, Theresa, Sullivan, Melissa, Paumier, Katrina, Holtzman, David M., Morris, John C., Benzinger, Tammie, Fagan, Anne M., Patterson, Bruce W., Bateman, Randall J.

“…Cerebrospinal fluid analysis and other measurements of amyloidosis, such as amyloid-binding positron emission tomography studies, are limited by cost and…”
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Validation of Plasma Amyloid-β 42/40 for Detecting Alzheimer Disease Amyloid Plaques by Li, Yan, Schindler, Suzanne E., Bollinger, James G., Ovod, Vitaliy, Mawuenyega, Kwasi G., Weiner, Michael W., Shaw, Leslie M., Masters, Colin L., Fowler, Christopher J., Trojanowski, John Q., Korecka, Magdalena, Martins, Ralph N., Janelidze, Shorena, Hansson, Oskar, Bateman, Randall J.

“…To determine the diagnostic accuracy of a plasma Aβ42/Aβ40 assay in classifying amyloid PET status across global research studies using samples collected by…”
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Comparative proteomic analysis of all-trans-retinoic acid treatment reveals systematic posttranscriptional control mechanisms in acute promyelocytic leukemia by Harris, Michael N., Ozpolat, Bulent, Abdi, Fadi, Gu, Sheng, Legler, Allison, Mawuenyega, Kwasi G., Tirado-Gomez, Maribel, Lopez-Berestein, Gabriel, Chen, Xian

“…All-trans-retinoic acid (ATRA) induces growth inhibition, differentiation, and apoptosis in cancer cells, including acute promyelocytic leukemia (APL). In APL,…”
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Tau Kinetics in Neurons and the Human Central Nervous System by Sato, Chihiro, Barthélemy, Nicolas R., Mawuenyega, Kwasi G., Patterson, Bruce W., Gordon, Brian A., Jockel-Balsarotti, Jennifer, Sullivan, Melissa, Crisp, Matthew J., Kasten, Tom, Kirmess, Kristopher M., Kanaan, Nicholas M., Yarasheski, Kevin E., Baker-Nigh, Alaina, Benzinger, Tammie L.S., Miller, Timothy M., Karch, Celeste M., Bateman, Randall J.

“…We developed stable isotope labeling and mass spectrometry approaches to measure the kinetics of multiple isoforms and fragments of tau in the human central…”
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Human apoE isoforms differentially regulate brain amyloid-β peptide clearance by Castellano, Joseph M, Kim, Jungsu, Stewart, Floy R, Jiang, Hong, DeMattos, Ronald B, Patterson, Bruce W, Fagan, Anne M, Morris, John C, Mawuenyega, Kwasi G, Cruchaga, Carlos, Goate, Alison M, Bales, Kelly R, Paul, Steven M, Bateman, Randall J, Holtzman, David M

“…The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late-onset, sporadic Alzheimer's disease (AD). The APOE ε4 allele markedly…”
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Suvorexant Acutely Decreases Tau Phosphorylation and Aβ in the Human CNS by Lucey, Brendan P., Liu, Haiyan, Toedebusch, Cristina D., Freund, David, Redrick, Tiara, Chahin, Samir L., Mawuenyega, Kwasi G., Bollinger, James G., Ovod, Vitaliy, Barthélemy, Nicolas R., Bateman, Randall J.

“…Objective In Alzheimer's disease, hyperphosphorylated tau is associated with formation of insoluble paired helical filaments that aggregate as neurofibrillary…”
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Amyloid-β efflux from the central nervous system into the plasma by Roberts, Kaleigh Filisa, Elbert, Donald L., Kasten, Tom P., Patterson, Bruce W., Sigurdson, Wendy C., Connors, Rose E., Ovod, Vitaliy, Munsell, Ling Y., Mawuenyega, Kwasi G., Miller-Thomas, Michelle M., Moran, Christopher J., Cross III, Dewitte T., Derdeyn, Colin P., Bateman, Randall J.

“…Objective The aim of this study was to measure the flux of amyloid‐β (Aβ) across the human cerebral capillary bed to determine whether transport into the blood…”
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Amyloid-beta isoform metabolism quantitation by stable isotope-labeled kinetics by Mawuenyega, Kwasi G., Kasten, Tom, Sigurdson, Wendy, Bateman, Randall J.

“…Abundant evidence suggests a central role for the amyloid-beta (Aβ) peptide in Alzheimer’s disease (AD) pathogenesis. Production and clearance of different Aβ…”
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Associations Between β-Amyloid Kinetics and the β-Amyloid Diurnal Pattern in the Central Nervous System by Lucey, Brendan P, Mawuenyega, Kwasi G, Patterson, Bruce W, Elbert, Donald L, Ovod, Vitaliy, Kasten, Tom, Morris, John C, Bateman, Randall J

“…Recent studies found that the concentration of amyloid-β (Aβ) fluctuates with the sleep-wake cycle. Although the amplitude of this day/night pattern attenuates…”
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Tau Kinetics in Neurons and the Human Central Nervous System by Sato, Chihiro, Barthélemy, Nicolas R., Mawuenyega, Kwasi G., Patterson, Bruce W., Gordon, Brian A., Jockel-Balsarotti, Jennifer, Sullivan, Melissa, Crisp, Matthew J., Kasten, Tom, Kirmess, Kristopher M., Kanaan, Nicholas M., Yarasheski, Kevin E., Baker-Nigh, Alaina, Benzinger, Tammie L.S., Miller, Timothy M., Karch, Celeste M., Bateman, Randall J.

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The structure of amyloid-β dimers in Alzheimer's disease brain: a step forward for oligomers by Bateman, Randall J, Mawuenyega, Kwasi G, Wildburger, Norelle C

“…This scientific commentary refers to 'Identification of neurotoxic cross-linked amyloid-β dimers in the Alzheimer's brain', by Brinkmalm et al…”
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A γ-secretase inhibitor decreases amyloid-β production in the central nervous system by Bateman, Randall J., Siemers, Eric R., Mawuenyega, Kwasi G., Wen, Guolin, Browning, Karen R., Sigurdson, Wendy C., Yarasheski, Kevin E., Friedrich, Stuart W., DeMattos, Ronald B., May, Patrick C., Paul, Steven M., Holtzman, David M.

“…Objective Accumulation of amyloid‐β (Aβ) by overproduction or underclearance in the central nervous system (CNS) is hypothesized to be a necessary event in the…”
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Human Central Nervous System (CNS) ApoE Isoforms Are Increased by Age, Differentially Altered by Amyloidosis, and Relative Amounts Reversed in the CNS Compared with Plasma by Baker-Nigh, Alaina T., Mawuenyega, Kwasi G., Bollinger, James G., Ovod, Vitaliy, Kasten, Tom, Franklin, Erin E., Liao, Fan, Jiang, Hong, Holtzman, David, Cairns, Nigel J., Morris, John C., Bateman, Randall J.

“…The risk of Alzheimer's disease (AD) is highly dependent on apolipoprotein-E (apoE) genotype. The reasons for apoE isoform-selective risk are uncertain;…”
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Increased Cerebrospinal Fluid Amyloid-β During Sleep Deprivation in Healthy Middle-Aged Adults Is Not Due to Stress or Circadian Disruption by Blattner, Margaret S, Panigrahi, Sunil K, Toedebusch, Cristina D, Hicks, Terry J, McLeland, Jennifer S, Banks, Ian R, Schaibley, Claire, Ovod, Vitaliy, Mawuenyega, Kwasi G, Bateman, Randall J, Wardlaw, Sharon L, Lucey, Brendan P

“…Concentrations of soluble amyloid-β (Aβ) oscillate with the sleep-wake cycle in the interstitial fluid of mice and cerebrospinal fluid (CSF) of humans…”
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