Search Results - "Mawson, Amanda"

ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-β signalling by Pinho, Andreia V., Van Bulck, Mathias, Chantrill, Lorraine, Arshi, Mehreen, Sklyarova, Tatyana, Herrmann, David, Vennin, Claire, Gallego-Ortega, David, Mawson, Amanda, Giry-Laterriere, Marc, Magenau, Astrid, Leuckx, Gunther, Baeyens, Luc, Gill, Anthony J., Phillips, Phoebe, Timpson, Paul, Biankin, Andrew V., Wu, Jianmin, Rooman, Ilse

“…Whereas genomic aberrations in the SLIT-ROBO pathway are frequent in pancreatic ductal adenocarcinoma (PDAC), their function in the pancreas is unclear. Here…”
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Activation of the viral sensor oligoadenylate synthetase 2 (Oas2) prevents pregnancy-driven mammary cancer metastases by Ho, Wing-Hong Jonathan, Law, Andrew M K, Masle-Farquhar, Etienne, Castillo, Lesley E, Mawson, Amanda, O'Bryan, Moira K, Goodnow, Christopher C, Gallego-Ortega, David, Oakes, Samantha R, Ormandy, Christopher J

“…The interferon response can influence the primary and metastatic activity of breast cancers and can interact with checkpoint immunotherapy to modulate its…”
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MCL-1 antagonism enhances the anti-invasive effects of dasatinib in pancreatic adenocarcinoma by Castillo, Lesley, Young, Adelaide I. J., Mawson, Amanda, Schafranek, Pia, Steinmann, Angela M., Nessem, Danielle, Parkin, Ashleigh, Johns, Amber, Chou, Angela, Law, Andrew M. K., Lucas, Morghan C., Murphy, Kendelle J., Deng, Niantao, Gallego-Ortega, David, Caldon, Catherine E., Timpson, Paul, Pajic, Marina, Ormandy, Christopher J., Oakes, Samantha R.

“…Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies. It is phenotypically heterogeneous with a highly unstable genome and…”
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Pancreas-Specific Sirt1-Deficiency in Mice Compromises Beta-Cell Function without Development of Hyperglycemia by Pinho, Andreia V, Bensellam, Mohammed, Wauters, Elke, Rees, Maxine, Giry-Laterriere, Marc, Mawson, Amanda, Ly, Le Quan, Biankin, Andrew V, Wu, Jianmin, Laybutt, D Ross, Rooman, Ilse

“…Sirtuin 1 (Sirt1) has been reported to be a critical positive regulator of glucose-stimulated insulin secretion in pancreatic beta-cells. The effects on islet…”
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Sirtuin-1 Regulates Acinar-to-Ductal Metaplasia and Supports Cancer Cell Viability in Pancreatic Cancer by WAUTERS, Elke, SANCHEZ-ARÉVALO LOBO, Victor J, TAO LIU, SERRANO, Manuel, BOUWENS, Luc, REAL, Francisco X, BIANKIN, Andrew V, ROOMAN, Ilse, PINHO, Andreia V, MAWSON, Amanda, HERRANZ, Daniel, JIANMIN WU, COWLEY, Mark J, COLVIN, Emily K, NGWAYI NJICOP, Erna, SUTHERLAND, Rob L

“…The exocrine pancreas can undergo acinar-to-ductal metaplasia (ADM), as in the case of pancreatitis where precursor lesions of pancreatic ductal adenocarcinoma…”
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Estrogen and insulin/IGF-1 cooperatively stimulate cell cycle progression in MCF-7 breast cancer cells through differential regulation of c-Myc and cyclin D1 by Mawson, Amanda, Lai, Angela, Carroll, Jason S., Sergio, C. Marcelo, Mitchell, Christopher J., Sarcevic, Boris

“…Estrogen and insulin/insulin-like growth factor-I (IGF-I) are major mitogens for breast epithelial cells and when co-administered, synergistically induce G 1–S…”
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Retinoid signaling in pancreatic cancer, injury and regeneration by Colvin, Emily K, Susanto, Johana M, Kench, James G, Ong, Vivienna N, Mawson, Amanda, Pinese, Mark, Chang, David K, Rooman, Ilse, O'Toole, Sandra A, Segara, Davendra, Musgrove, Elizabeth A, Sutherland, Robert L, Apte, Minoti V, Scarlett, Christopher J, Biankin, Andrew V

“…Activation of embryonic signaling pathways quiescent in the adult pancreas is a feature of pancreatic cancer (PC). These discoveries have led to the…”
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SET-related Cell Division Autoantigen-1 (CDA1) Arrests Cell Growth by Chai, Zhonglin, Sarcevic, Boris, Mawson, Amanda, Toh, Ban-Hock

“…We used an autoimmune serum from a patient with discoid lupus erythematosus to clone a cDNA of 2808 base pairs. Its open reading frame of 2079 base pairs…”
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Emergence of Enzalutamide Resistance in Prostate Cancer is Associated with BCL-2 and IKKB Dependencies by Liang, Yi, Jeganathan, Sujeeve, Marastoni, Stefano, Sharp, Adam, Figueiredo, Ines, Marcellus, Richard, Mawson, Amanda, Shalev, Zvi, Pesic, Aleksandra, Sweet, Joan, Guo, Haiyang, Uehling, David, Gurel, Bora, Neeb, Antje, He, Housheng Hansen, Montgomery, Bruce, Koritzinsky, Marianne, Oakes, Samantha, de Bono, Johann S, Gleave, Martin, Zoubeidi, Amina, Wouters, Bradly G, Joshua, Anthony M

“…Although enzalutamide (ENZ) has been widely used to treat or castration-resistant metastatic prostate cancer, resistance develops and disease progression is…”
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SOX9 regulates ERBB signalling in pancreatic cancer development by Grimont, Adrien, Pinho, Andreia V, Cowley, Mark J, Augereau, Cécile, Mawson, Amanda, Giry-Laterrière, Marc, Van den Steen, Géraldine, Waddell, Nicola, Pajic, Marina, Sempoux, Christine, Wu, Jianmin, Grimmond, Sean M, Biankin, Andrew V, Lemaigre, Frédéric P, Rooman, Ilse, Jacquemin, Patrick

“…The transcription factor SOX9 was recently shown to stimulate ductal gene expression in pancreatic acinar-to-ductal metaplasia and to accelerate development of…”
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MutY-Homolog (MYH) inhibition reduces pancreatic cancer cell growth and increases chemosensitivity by Sharbeen, George, Youkhana, Janet, Mawson, Amanda, McCarroll, Joshua, Nunez, Andrea, Biankin, Andrew, Johns, Amber, Goldstein, David, Phillips, Phoebe

“…Patients with pancreatic ductal adenocarcinoma (PC) have a poor prognosis due to metastases and chemoresistance. PC is characterized by extensive fibrosis,…”
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Cdc34 C-terminal tail phosphorylation regulates Skp1/cullin/F-box (SCF)-mediated ubiquitination and cell cycle progression by Sadowski, Martin, Mawson, Amanda, Baker, Rohan, Sarcevic, Boris

“…The ubiquitin-conjugating enzyme Cdc34 (cell division cycle 34) plays an essential role in promoting the G1-S-phase transition of the eukaryotic cell cycle and…”
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The epigenetic agents suberoylanilide hydroxamic acid and 5-AZA-2′ deoxycytidine decrease cell proliferation, induce cell death and delay the growth of MiaPaCa2 pancreatic cancer cells in vivo by SUSANTO, JOHANA M, COLVIN, EMILY K, PINESE, MARK, CHANG, DAVID K, PAJIC, MARINA, MAWSON, AMANDA, CALDON, C. ELIZABETH, MUSGROVE, ELIZABETH A, HENSHALL, SUSAN M, SUTHERLAND, ROBERT L, BIANKIN, ANDREW V, SCARLETT, CHRISTOPHER J

“…Despite incremental advances in the diagnosis and treatment for pancreatic cancer (PC), the 5-year survival rate remains <5%. Novel therapies to increase…”
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Expression of the axon guidance protein Robo1 in pancreatic ductal adenocarcinoma from smokers compared to nonsmokers by Chantrill, Lorraine A., Pinho, Andreia, Wu, Jiamin, Giry-Latierre, Marc, Mawson, Amanda, Rees, Maxine, Johns, Amber, Brancato, Mary-Anne, Chin, Venessa T., Nagrial, Adnan, Scarlett, Christopher James, Gill, Anthony J., Biankin, Andrew Victor, Rooman, Ilse

“…Abstract only 305 Background: The most important modifiable risk factor for the development of pancreas cancer is smoking, which accounts for up to 25% of…”
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Abstract LB-73: SOX9 regulates EGFR/ERBB signaling in pancreatic cancer by Pinho, Andreia V., Grimont, Adrien, Cowley, Mark J., Augereau, Cecile, Mawson, Amanda, Giry-Laterriere, Marc, Steen, Geraldine Van den, Waddell, Nicola, Pajic, Marina, Sempoux, Christine, Wu, Jianmin, Grimmond, Sean M., Biankin, Andrew V., Lemaigre, Frederic P., Jacquemin, Patrick, Rooman, Ilse

“…Abstract The transcription factor SOX9 has recently been shown to have a role in the ontogenesis of pancreatic ductal adenocarcinoma (PDAC) through metaplastic…”
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Sirtuin 1 stimulates the proliferation and the expression of glycolysis genes in pancreatic neoplastic lesions by Pinho, Andreia V, Mawson, Amanda, Gill, Anthony, Arshi, Mehreen, Warmerdam, Max, Giry-Laterriere, Marc, Eling, Nils, Lie, Triyana, Kuster, Evelyne, Camargo, Simone, Biankin, Andrew V, Wu, Jianmin, Rooman, Ilse

“…Metabolic reprogramming is a feature of neoplasia and tumor growth. Sirtuin 1 (SIRT1) is a lysine deacetylase of multiple targets including metabolic…”
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Regulation of the ubiquitin-conjugating enzyme hHR6A by CDK-mediated phosphorylation by Sarcevic, Boris, Mawson, Amanda, Baker, Rohan T, Sutherland, Robert L

“…Cell cycle progression in eukaryotes is mediated by phosphorylation of protein substrates by the cyclin‐dependent kinases (CDKs). We screened a cDNA library by…”
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