Ficus religiosa L. bark extracts inhibit infection by herpes simplex virus type 2 in vitro

Ficus religiosa L. bark extracts inhibit infection by herpes simplex virus type 2 in vitro

Ficus religiosa extracts have been used in traditional Indian medicine to treat sexually transmitted infections such as gonorrhea and genital ulcers. The aim of this study was to investigate the antiviral activity of F. religiosa extracts against herpes simplex virus type 2 (HSV-2), the main causati...

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Bibliographic Details
Published in:Archives of virology Vol. 161; no. 12; pp. 3509 - 3514
Main Authors: Ghosh, Manik, Civra, Andrea, Rittà, Massimo, Cagno, Valeria, Mavuduru, Siva Ganesh, Awasthi, Preeti, Lembo, David, Donalisio, Manuela
Format: Journal Article
Language:English
Published: Vienna Springer Vienna 01-12-2016
Springer Nature B.V
Subjects:
Antiviral Agents - isolation & purification
Antiviral Agents - pharmacology
Biomedical and Life Sciences
Biomedicine
Brief Report
Cytotoxicity
Ficus - chemistry
Ficus religiosa
Herpes viruses
Herpesviridae
Herpesvirus 2, Human - drug effects
Herpesvirus 2, Human - physiology
HIV
Human immunodeficiency virus
Humans
Infections
Infectious Diseases
Medical Microbiology
Plant Bark - chemistry
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Sexually transmitted diseases
STD
Ulcers
Virology
Virus Attachment - drug effects
Virus Inactivation
Virus Internalization - drug effects
Plant extract
Antiviral
HSV-2
Ficus religiosa
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Summary:Ficus religiosa extracts have been used in traditional Indian medicine to treat sexually transmitted infections such as gonorrhea and genital ulcers. The aim of this study was to investigate the antiviral activity of F. religiosa extracts against herpes simplex virus type 2 (HSV-2), the main causative agent of genital ulcers and sores. Water and chloroform bark extracts were the most active against HSV-2, and also against an acyclovir-resistant strain. We demonstrate that the water extract has a direct virus-inactivating activity. By contrast, the chloroform extract inhibits viral attachment and entry and limits the production of viral progeny.
Bibliography:ObjectType-Article-1
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ISSN:0304-8608
1432-8798
DOI:10.1007/s00705-016-3032-3