Search Results - "Mavromatis, Lucas A."

Mendelian Randomization Study of PCSK9 and HMG-CoA Reductase Inhibition and Cognitive Function by Rosoff, Daniel B., Bell, Andrew S., Jung, Jeesun, Wagner, Josephin, Mavromatis, Lucas A., Lohoff, Falk W.

“…Lipid-lowering therapy with statins and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition are effective strategies in reducing cardiovascular…”
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Multi-omic underpinnings of epigenetic aging and human longevity by Mavromatis, Lucas A., Rosoff, Daniel B., Bell, Andrew S., Jung, Jeesun, Wagner, Josephin, Lohoff, Falk W.

“…Biological aging is accompanied by increasing morbidity, mortality, and healthcare costs; however, its molecular mechanisms are poorly understood. Here, we use…”
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PREVENT Risk Score and Use of Cardioprotective Agents in Type 2 Diabetes: An Analysis of NHANES 2013 to 2020 by Mavromatis, Lucas A., Wang, Dan, Selvin, Elizabeth, Berger, Jeffery S., Grams, Morgan E., Shin, Jung‐Im

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Comparing the Relationships of Genetically Proxied PCSK9 Inhibition With Mood Disorders, Cognition, and Dementia Between Men and Women: A Drug-Target Mendelian Randomization Study by Bell, Andrew S, Rosoff, Daniel B, Mavromatis, Lucas A, Jung, Jeesun, Wagner, Josephin, Lohoff, Falk W

“…Background PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors are important therapeutic options for reducing cardiovascular disease risk;…”
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Association Between Brain Structure and Alcohol Use Behaviors in Adults: A Mendelian Randomization and Multiomics Study by Mavromatis, Lucas A, Rosoff, Daniel B, Cupertino, Renata B, Garavan, Hugh, Mackey, Scott, Lohoff, Falk W

“…Past studies have identified associations between brain macrostructure and alcohol use behaviors. However, identifying directional associations between these…”
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Major Psychiatric Disorders, Substance Use Behaviors, and Longevity by Rosoff, Daniel B, Hamandi, Ali M, Bell, Andrew S, Mavromatis, Lucas A, Park, Lauren M, Jung, Jeesun, Wagner, Josephin, Lohoff, Falk W

“…Observational studies suggest that major psychiatric disorders and substance use behaviors reduce longevity, making it difficult to disentangle their…”
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PCSK9 inhibition attenuates alcohol-associated neuronal oxidative stress and cellular injury by Wagner, Josephin, Park, Lauren M., Mukhopadhyay, Partha, Matyas, Csaba, Trojnar, Eszter, Damadzic, Ruslan, Jung, Jeesun, Bell, Andrew S., Mavromatis, Lucas A., Hamandi, Ali M., Rosoff, Daniel B., Vendruscolo, Leandro F., Koob, George F., Pacher, Pal, Lohoff, Falk W.

“…•PCSK9 inhibition via alirocumab reduces ethanol-induced injury in the rodent brain.•Alirocumab enhances low-density lipoprotein receptor expression in…”
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Additive Effects of Stress and Alcohol Exposure on Accelerated Epigenetic Aging in Alcohol Use Disorder by Jung, Jeesun, McCartney, Daniel L., Wagner, Josephin, Yoo, Joyce, Bell, Andrew S., Mavromatis, Lucas A., Rosoff, Daniel B., Hodgkinson, Colin A., Sun, Hui, Schwandt, Melanie, Diazgranados, Nancy, Smith, Alicia K., Michopoulos, Vasiliki, Powers, Abigail, Stevens, Jennifer, Bradley, Bekh, Fani, Negar, Walker, Rosie M., Campbell, Archie, Porteous, David J., McIntosh, Andrew M., Horvath, Steve, Marioni, Riccardo E., Evans, Kathryn L., Goldman, David, Lohoff, Falk W.

“…Stress contributes to premature aging and susceptibility to alcohol use disorder (AUD), and AUD itself is a factor in premature aging; however, the…”
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Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging by Rosoff, Daniel B, Mavromatis, Lucas A, Bell, Andrew S, Wagner, Josephin, Jung, Jeesun, Marioni, Riccardo E, Davey Smith, George, Horvath, Steve, Lohoff, Falk W

“…The concept of aging is complex, including many related phenotypes such as healthspan, lifespan, extreme longevity, frailty and epigenetic aging, suggesting…”
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A multi-omics Mendelian randomization study identifies new therapeutic targets for alcohol use disorder and problem drinking by Rosoff, Daniel B., Wagner, Josephin, Bell, Andrew S., Mavromatis, Lucas A., Jung, Jeesun, Lohoff, Falk W.

“…Integrating proteomic and transcriptomic data with genetic architectures of problematic alcohol use and alcohol consumption behaviours can advance our…”
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Assessing the Impact of PCSK9 and HMGCR Inhibition on Liver Function: Drug-Target Mendelian Randomization Analyses in Four Ancestries by Rosoff, Daniel B, Bell, Andrew S, Wagner, Josephin, Mavromatis, Lucas A, Hamandi, Ali, Park, Lauren, Jung, Jeesun, Lohoff, Falk W

“…Observational studies have linked lipid-lowering drug targets pro-protein convertase subtilisin/kexin 9 (PCSK9) and HMG-CoA reductase (HMGCR) with adverse…”
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Evaluating the Cardiovascular Impact of Genetically Proxied PCSK9 and HMGCR Inhibition in East Asian and European Populations: A Drug-Target Mendelian Randomization Study by Rosoff, Daniel B, Bell, Andrew S, Mavromatis, Lucas A, Hamandi, Ali, Park, Lauren, Jung, Jeesun, Wagner, Josephin, Pacher, Pal, Ray, David, Davey Smith, George, Lohoff, Falk W

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Assessing the Impact of PCSK9 and HMGCR Inhibition on Liver Function: Drug-Target Mendelian Randomization Analyses in Four AncestriesSummary by Daniel B. Rosoff, Andrew S. Bell, Josephin Wagner, Lucas A. Mavromatis, Ali Hamandi, Lauren Park, Jeesun Jung, Falk W. Lohoff

“…Background & Aims: Observational studies have linked lipid-lowering drug targets pro-protein convertase subtilisin/kexin 9 (PCSK9) and HMG-CoA reductase…”
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