Search Results - "Mavor, David"

Rescue of conformational dynamics in enzyme catalysis by directed evolution by Otten, Renee, Liu, Lin, Kenner, Lillian R., Clarkson, Michael W., Mavor, David, Tawfik, Dan S., Kern, Dorothee, Fraser, James S.

“…Rational design and directed evolution have proved to be successful approaches to increase catalytic efficiencies of both natural and artificial enzymes…”
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Comprehensive fitness maps of Hsp90 show widespread environmental dependence by Flynn, Julia M, Rossouw, Ammeret, Cote-Hammarlof, Pamela, Fragata, Inês, Mavor, David, Hollins, 3rd, Carl, Bank, Claudia, Bolon, Daniel Na

“…Gene-environment interactions have long been theorized to influence molecular evolution. However, the environmental dependence of most mutations remains…”
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Systematic profiling of dominant ubiquitin variants reveals key functional nodes contributing to evolutionary selection by Padhy, Amrita Arpita, Mavor, David, Sahoo, Subhashree, Bolon, Daniel N.A., Mishra, Parul

“…Dominant-negative mutations can help to investigate the biological mechanisms and to understand the selective pressures for multifunctional proteins. However,…”
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Thermodynamics of Rev–RNA Interactions in HIV‑1 Rev–RRE Assembly by Jayaraman, Bhargavi, Mavor, David, Gross, John D, Frankel, Alan D

“…The HIV-1 protein Rev facilitates the nuclear export of intron-containing viral mRNAs by recognizing a structured RNA site, the Rev-response-element (RRE),…”
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RNA-directed remodeling of the HIV-1 protein Rev orchestrates assembly of the Rev-Rev response element complex by Jayaraman, Bhargavi, Crosby, David C, Homer, Christina, Ribeiro, Isabel, Mavor, David, Frankel, Alan D

“…The HIV-1 protein Rev controls a critical step in viral replication by mediating the nuclear export of unspliced and singly-spliced viral mRNAs. Multiple Rev…”
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The Adaptive Potential of the Middle Domain of Yeast Hsp90 by Cote-Hammarlof, Pamela A, Fragata, Inês, Flynn, Julia, Mavor, David, Zeldovich, Konstantin B, Bank, Claudia, Bolon, Daniel N A

“…Abstract The distribution of fitness effects (DFEs) of new mutations across different environments quantifies the potential for adaptation in a given…”
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Genetic interaction mapping informs integrative structure determination of protein complexes by Braberg, Hannes, Echeverria, Ignacia, Bohn, Stefan, Cimermancic, Peter, Shiver, Anthony, Alexander, Richard, Xu, Jiewei, Shales, Michael, Dronamraju, Raghuvar, Jiang, Shuangying, Dwivedi, Gajendradhar, Bogdanoff, Derek, Chaung, Kaitlin K, Hüttenhain, Ruth, Wang, Shuyi, Mavor, David, Pellarin, Riccardo, Schneidman, Dina, Bader, Joel S, Fraser, James S, Morris, John, Haber, James E, Strahl, Brian D, Gross, Carol A, Dai, Junbiao, Boeke, Jef D, Sali, Andrej, Krogan, Nevan J

“…Determining structures of protein complexes is crucial for understanding cellular functions. Here, we describe an integrative structure determination approach…”
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A complete allosteric map of a GTPase switch in its native cellular network by Mathy, Christopher J P, Mishra, Parul, Flynn, Julia M, Perica, Tina, Mavor, David, Bolon, Daniel N A, Kortemme, Tanja

“…Allosteric regulation is central to protein function in cellular networks. A fundamental open question is whether cellular regulation of allosteric proteins…”
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Genetic interaction mapping informs integrative structure determination of protein complexes by Braberg, Hannes, Echeverria, Ignacia, Bohn, Stefan, Cimermancic, Peter, Shiver, Anthony, Alexander, Richard, Xu, Jiewei, Shales, Michael, Dronamraju, Raghuvar, Jiang, Shuangying, Dwivedi, Gajendradhar, Bogdanoff, Derek, Chaung, Kaitlin K., Hüttenhain, Ruth, Wang, Shuyi, Mavor, David, Pellarin, Riccardo, Schneidman, Dina, Bader, Joel S., Fraser, James S., Morris, John, Haber, James E., Strahl, Brian D., Gross, Carol A., Dai, Junbiao, Boeke, Jef D., Sali, Andrej, Krogan, Nevan J.

“…From phenotype to structureMuch insight has come from structures of macromolecular complexes determined by methods such as crystallography or cryo–electron…”
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Analyses of HIV proteases variants at the threshold of viability reveals relationships between processing efficiency and fitness by Schneider-Nachum, Gily, Flynn, Julia, Mavor, David, Schiffer, Celia A, Bolon, Daniel N A

“…Abstract Investigating the relationships between protein function and fitness provides keys for understanding biochemical mechanisms that underly evolution…”
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Ler of pathogenic Escherichia coli forms toroidal protein-DNA complexes by MELLIES, Jay L, BENISON, Gregory, MCNITT, William, MAVOR, David, BONIFACE, Chris, LARABEE, Frederick J

“…Enteropathogenic and enterohaemorrhagic Escherichia coli are related pathotypes of bacteria that cause acute watery diarrhoea and haemorrhagic colitis,…”
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Determination of the Ubiquitin Fitness Landscape Under Seventeen Chemical Conditions in a Classroom Setting by Mavor, David Carl

“…Ubiquitin is essential for eukaryotic life and varies in only 3 amino acid positions between yeast and humans. However, recent deep sequencing studies indicate…”
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Ler interdomain linker is essential for anti-silencing activity in enteropathogenic Escherichia coli by Mellies, Jay L, Larabee, Fredrick J, Zarr, Melissa A, Horback, Katy L, Lorenzen, Emily, Mavor, David

“…1 Biology Department, Reed College, Portland, OR 97202, USA 2 University of Illinois Urbana-Champaign, Urbana, IL 61801, USA 3 Johns Hopkins University,…”
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