Search Results - "Maviza, Tinashe P."
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Tetracenomycin X inhibits translation by binding within the ribosomal exit tunnel
Published in Nature chemical biology (01-10-2020)“…The increase in multi-drug resistant pathogenic bacteria is making our current arsenal of clinically used antibiotics obsolete, highlighting the urgent need…”
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2
Insights into the molecular mechanism of translation inhibition by the ribosome-targeting antibiotic thermorubin
Published in Nucleic acids research (11-01-2023)“…Thermorubin (THR) is an aromatic anthracenopyranone antibiotic active against both Gram-positive and Gram-negative bacteria. It is known to bind to the 70S…”
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RtcB2-PrfH Operon Protects E. coli ATCC25922 Strain from Colicin E3 Toxin
Published in International journal of molecular sciences (09-06-2022)“…In the bid to survive and thrive in an environmental setting, bacterial species constantly interact and compete for resources and space in the microbial…”
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The cyclic octapeptide antibiotic argyrin B inhibits translation by trapping EF-G on the ribosome during translocation
Published in Proceedings of the National Academy of Sciences - PNAS (10-05-2022)“…Argyrins are a family of naturally produced octapeptides that display promising antimicrobial activity against Pseudomonas aeruginosa. Argyrin B (ArgB) has…”
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5
An easy tool to monitor the elemental steps of in vitro translation via gel electrophoresis of fluorescently labeled small peptides
Published in RNA (Cambridge) (01-03-2024)“…Several methods are available to visualize and assess the kinetics and efficiency of elemental steps of protein biosynthesis. However, each of these methods…”
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Characterization of a novel natural tetracenomycin reveals crucial role of 4-hydroxy group in ribosome binding
Published in Biochimie (01-03-2023)“…The aromatic polyketides tetracenomycins were recently found to be potent inhibitors of protein synthesis. Their binding site is located in a unique locus…”
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Biological evaluation and spectral characterization of a novel tetracenomycin X congener
Published in Biochimie (01-01-2022)“…The aromatic polyketide tetracenomycin X (TcmX) was recently found to be a potent inhibitor of protein synthesis; its binding site is located in a unique locus…”
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Nybomycin Inhibits both Fluoroquinolone-Sensitive and Fluoroquinolone-Resistant Escherichia coli DNA Gyrase
Published in Antimicrobial agents and chemotherapy (19-04-2021)“…Bacterial type II topoisomerases, DNA gyrase and topoisomerase IV, are targets of many antibiotics, including fluoroquinolones (FQs). Unfortunately, a number…”
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Nybomycin inhibits both types of E. coli DNA gyrase - fluoroquinolone-sensitive and fluoroquinolone-resistant
Published in Antimicrobial agents and chemotherapy (01-05-2023)“…Bacterial type II topoisomerases, DNA gyrase and topoisomerase IV, are targets of many antibiotics including fluoroquinolones (FQs). Unfortunately, a number of…”
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