Search Results - "Mautino, Mario"

IDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1-methyl-tryptophan by Metz, Richard, Rust, Sonja, DuHadaway, James B., Mautino, Mario R., Munn, David H., Vahanian, Nicholas N., Link, Charles J., Prendergast, George C.

“…Tryptophan catabolism by indoleamine 2,3-dioxygenase (IDO) alters inflammation and favors T-cell tolerance in cancer, but the underlying molecular mechanisms…”
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Amino acid catabolism: a pivotal regulator of innate and adaptive immunity by McGaha, Tracy L., Huang, Lei, Lemos, Henrique, Metz, Richard, Mautino, Mario, Prendergast, George C., Mellor, Andrew L.

“…Summary Enhanced amino acid catabolism is a common response to inflammation, but the immunologic significance of altered amino acid consumption remains…”
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Discovery of indoximod prodrugs and characterization of clinical candidate NLG802 by Kumar, Sanjeev, Jaipuri, Firoz A., Waldo, Jesse P., Potturi, Hima, Marcinowicz, Agnieszka, Adams, James, Van Allen, Clarissa, Zhuang, Hong, Vahanian, Nicholas, Link, Charles, Brincks, Erik L., Mautino, Mario R.

“…A series of different prodrugs of indoximod, including estesrs and peptide amides were synthesized with the aim of improving its oral bioavailability in…”
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Phase Ia study of the indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor navoximod (GDC-0919) in patients with recurrent advanced solid tumors by Nayak-Kapoor, Asha, Hao, Zhonglin, Sadek, Ramses, Dobbins, Robin, Marshall, Lisa, Vahanian, Nicholas N, Jay Ramsey, W, Kennedy, Eugene, Mautino, Mario R, Link, Charles J, Lin, Ray S, Royer-Joo, Stephanie, Liang, Xiaorong, Salphati, Laurent, Morrissey, Kari M, Mahrus, Sami, McCall, Bruce, Pirzkall, Andrea, Munn, David H, Janik, John E, Khleif, Samir N

“…Indoleamine-2,3-dioxygenase 1 (IDO1) catalyzes the oxidation of tryptophan into kynurenine and is partially responsible for acquired immune tolerance…”
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Indoximod opposes the immunosuppressive effects mediated by IDO and TDO via modulation of AhR function and activation of mTORC1 by Brincks, Erik L., Adams, James, Wang, Lifu, Turner, Benjamin, Marcinowicz, Agnieszka, Ke, Jiyuan, Essmann, Michael, Mautino, Lucía M., Allen, Clarissa Van, Kumar, Sanjeev, Vahanian, Nicholas, Link, Charles, Mautino, Mario R.

“…Indoximod has shaped our understanding of the biology of IDO1 in the control of immune responses, though its mechanism of action has been poorly understood…”
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The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment by Sharma, Madhav D, Shinde, Rahul, McGaha, Tracy L, Huang, Lei, Holmgaard, Rikke B, Wolchok, Jedd D, Mautino, Mario R, Celis, Esteban, Sharpe, Arlene H, Francisco, Loise M, Powell, Jonathan D, Yagita, Hideo, Mellor, Andrew L, Blazar, Bruce R, Munn, David H

“…The tumor microenvironment is profoundly immunosuppressive. We show that multiple tumor types create intratumoral immune suppression driven by a specialized…”
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Implementation of the CYP Index for the Design of Selective Tryptophan-2,3-dioxygenase Inhibitors by Parr, Brendan T, Pastor, Richard, Sellers, Benjamin D, Pei, Zhonghua, Jaipuri, Firoz A, Castanedo, Georgette M, Gazzard, Lewis, Kumar, Sanjeev, Li, Xiaokai, Liu, Wen, Mendonca, Rohan, Pavana, Roheeth K, Potturi, Hima, Shao, Cheng, Velvadapu, Venkata, Waldo, Jesse P, Wu, Guosheng, Yuen, Po-wai, Zhang, Zuhui, Zhang, Yamin, Harris, Seth F, Oh, Angela J, DiPasquale, Antonio, Dement, Kevin, La, Hank, Goon, Leanne, Gustafson, Amy, VanderPorten, Erica C, Mautino, Mario R, Liu, Yichin

“…A class of imidazoisoindole (III) heme-binding indoleamine-2,3-dioxygenase (IDO1) inhibitors were optimized via structure-based drug design into a series of…”
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Discovery of Clinical Candidate (1 R ,4 r )-4-(( R )-2-(( S )-6-Fluoro-5 H -imidazo[5,1- a ]isoindol-5-yl)-1-hydroxyethyl)cyclohexan-1-ol (Navoximod), a Potent and Selective Inhibitor of Indoleamine 2,3-Dioxygenase 1 by Kumar, Sanjeev, Waldo, Jesse P, Jaipuri, Firoz A, Marcinowicz, Agnieszka, Van Allen, Clarissa, Adams, James, Kesharwani, Tanay, Zhang, Xiaoxia, Metz, Richard, Oh, Angela J, Harris, Seth F, Mautino, Mario R

“…A novel class of 5-substituted 5 -imidazo[5,1- ]isoindoles are described as potent inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1). A structure-based drug…”
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Effective treatment of preexisting melanoma with whole cell vaccines expressing α(1,3)-galactosyl epitopes by ROSSI, Gabriela R, MAUTINO, Mario R, UNFER, Robert C, SEREGINA, Tatiana M, VAHANIAN, Nicholas, LINK, Charles J

“…The hyperacute immune response in humans is a potent mechanism of xenograft rejection mediated by complement-fixing natural antibodies recognizing…”
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Discovery of Clinical Candidate (1R,4r)‑4-((R)‑2-((S)‑6-Fluoro‑5H‑imidazo[5,1‑a]isoindol-5-yl)-1-hydroxyethyl)cyclohexan-1-ol (Navoximod), a Potent and Selective Inhibitor of Indoleamine 2,3-Dioxygenase 1 by Kumar, Sanjeev, Waldo, Jesse P, Jaipuri, Firoz A, Marcinowicz, Agnieszka, Van Allen, Clarissa, Adams, James, Kesharwani, Tanay, Zhang, Xiaoxia, Metz, Richard, Oh, Angela J, Harris, Seth F, Mautino, Mario R

“…A novel class of 5-substituted 5H-imidazo­[5,1-a]­isoindoles are described as potent inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1). A structure-based drug…”
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The PTEN pathway in Tregs functions as a critical driver of the immunosuppressive tumor microenvironment and tolerance to apoptotic cells by Sharma, Madhav, Shinde, Rahul, McGaha, Tracy, Huang, Lei, Holmgaard, Rikke, Wolchok, Jedd, Mautino, Mario, Celis, Esteban, Sharpe, Arlene, Francisco, Loise, Powell, Jonathan, Yagita, Hideo, Mellor, Andrew, Blazar, Bruce, Munn, David

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Lentiviral vectors for gene therapy of HIV-1 infection by Mautino, Mario R

“…Lentiviral vectors based on HIV-1, HIV-2, or SIV have the ability to transduce dividing and non-dividing T cells, dendritic cells, hematopoietic stem cells and…”
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Enhanced inhibition of human immunodeficiency virus type 1 replication by novel lentiviral vectors expressing human immunodeficiency virus type 1 envelope antisense RNA by Mautino, Mario R, Morgan, Richard A

“…We have developed optimized versions of a conditionally replicating human immunodeficiency virus type 1 (HIV-1)-based lentiviral vector for gene therapy of…”
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High-efficiency lentiviral vector-mediated gene transfer into murine macrophages and activated splenic B lymphocytes by Rossi, Gabriela R, Mautino, Mario R, Morgan, Richard A

“…The goal of the present report was to determine if lentiviral vectors could mediate gene transfer into murine terminally differentiated macrophages and mature…”
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Potent inhibition of human immunodeficiency virus type 1 replication by conditionally replicating human immunodeficiency virus-based lentiviral vectors expressing envelope antisense mRNA by Mautino, M R, Morgan, R A

“…We describe an HIV-based lentiviral vector that expresses a 1-kb antisense mRNA directed against the HIV-1 mRNAs containing env sequences. The expression of…”
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Gene therapy of HIV-1 infection using lentiviral vectors expressing anti-HIV-1 genes by Mautino, Mario R, Morgan, Richard A

“…The use of vectors based on primate lentiviruses for gene therapy of human immunodeficiency virus type 1 (HIV-1) infection has many potential advantages over…”
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A phase I study of indoximod in patients with advanced malignancies by Soliman, Hatem H, Minton, Susan E, Han, Hyo Sook, Ismail-Khan, Roohi, Neuger, Anthony, Khambati, Fatema, Noyes, David, Lush, Richard, Chiappori, Alberto A, Roberts, John D, Link, Charles, Vahanian, Nicholas N, Mautino, Mario, Streicher, Howard, Sullivan, Daniel M, Antonia, Scott J

“…Indoximod is an oral inhibitor of the indoleamine 2,3-dioxygenase pathway, which causes tumor-mediated immunosuppression. Primary endpoints were maximum…”
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The PTEN pathway in T regs is a critical driver of the suppressive tumor microenvironment by Sharma, Madhav D., Shinde, Rahul, McGaha, Tracy L., Huang, Lei, Holmgaard, Rikke B., Wolchok, Jedd D., Mautino, Mario R., Celis, Esteban, Sharpe, Arlene H., Francisco, Loise M., Powell, Jonathan D., Yagita, Hideo, Mellor, Andrew L., Blazar, Bruce R., Munn, David H.

“…Tumors depend on a specialized pathway of regulatory T cell activation to create their immunosuppressive microenvironment, which can be blocked by inhibiting…”
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Abstract 3753: Indoximod modulates AhR-driven transcription of genes that control immune function by Brincks, Erik L., Adams, James, Essmann, Michael, Turner, Benjamin A., Wang, Lifu, Ke, Jiyuan, Marcinowicz, Agnieszka, Vahanian, Nicholas, Link, Charles J., Mautino, Mario R.

“…Abstract The IDO pathway mediates immunosuppressive effects by metabolizing tryptophan (Trp) into kynurenine (Kyn). The depletion of Trp stimulates downstream…”
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Inhibition of Human Immunodeficiency Virus Type 1 (HIV-1) Replication by HIV-1-Based Lentivirus Vectors Expressing Transdominant Rev by Mautino, M R, Keiser, N, Morgan, R A

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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