Search Results - "Maurya, Devendra S."
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The Unexpected Importance of the Primary Structure of the Hydrophobic Part of One-Component Ionizable Amphiphilic Janus Dendrimers in Targeted mRNA Delivery Activity
Published in Journal of the American Chemical Society (23-03-2022)“…Viral and synthetic vectors for delivery of nucleic acids impacted genetic nanomedicine by aiding the rapid development of the extraordinarily efficient…”
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2
Assembling Complex Macromolecules and Self-Organizations of Biological Relevance with Cu(I)-Catalyzed Azide-Alkyne, Thio-Bromo, and TERMINI Double "Click" Reactions
Published in Polymers (21-02-2023)“…In 2022, the Nobel Prize in Chemistry was awarded to Bertozzi, Meldal, and Sharpless "for the development of click chemistry and biorthogonal chemistry". Since…”
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Screening Libraries to Discover Molecular Design Principles for the Targeted Delivery of mRNA with One-Component Ionizable Amphiphilic Janus Dendrimers Derived from Plant Phenolic Acids
Published in Pharmaceutics (23-05-2023)“…Viral and synthetic vectors to deliver nucleic acids were key to the rapid development of extraordinarily efficient COVID-19 vaccines. The four-component lipid…”
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Targeted Delivery of mRNA with One-Component Ionizable Amphiphilic Janus Dendrimers
Published in Journal of the American Chemical Society (03-11-2021)“…Targeted and efficient delivery of nucleic acids with viral and synthetic vectors is the key step of genetic nanomedicine. The four-component lipid…”
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Me 6 -TREN/TREN Mixed-Ligand Effect During SET-LRP in the Catalytically Active DMSO Revitalizes TREN into an Excellent Ligand
Published in Biomacromolecules (11-05-2020)“…A mixed-ligand effect was observed for mixtures of tris(2-dimethylaminoethyl)amine (Me -TREN) with tris(2-aminoethyl)amine (TREN) ligands during Cu(0)…”
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One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA
Published in Journal of the American Chemical Society (11-08-2021)“…Efficient viral or nonviral delivery of nucleic acids is the key step of genetic nanomedicine. Both viral and synthetic vectors have been successfully employed…”
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Targeted and Equally Distributed Delivery of mRNA to Organs with Pentaerythritol-Based One-Component Ionizable Amphiphilic Janus Dendrimers
Published in Journal of the American Chemical Society (30-08-2023)“…Delivery of nucleic acids with viral and synthetic vectors has pioneered genetic nanomedicine. Four-component lipid nanoparticles (LNPs) consisting of…”
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Me6‑TREN/TREN Mixed-Ligand Effect During SET-LRP in the Catalytically Active DMSO Revitalizes TREN into an Excellent Ligand
Published in Biomacromolecules (11-05-2020)“…A mixed-ligand effect was observed for mixtures of tris(2-dimethylaminoethyl)amine (Me6-TREN) with tris(2-aminoethyl)amine (TREN) ligands during Cu(0)…”
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The Constitutional Isomerism of One-Component Ionizable Amphiphilic Janus Dendrimers Orchestrates the Total and Targeted Activities of mRNA Delivery
Published in Journal of the American Chemical Society (14-02-2024)“…Constitutional isomerism has been previously demonstrated by one of our laboratories to represent a powerful design strategy for the elaboration of complex…”
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Replacing Cu(II)Br 2 with Me 6 -TREN in Biphasic Cu(0)/TREN Catalyzed SET-LRP Reveals the Mixed-Ligand Effect
Published in Biomacromolecules (13-01-2020)“…The mixed-ligand system consisting of tris(2-aminoethyl)amine (TREN) and tris(2-dimethylaminoethyl)amine (Me -TREN) during the Cu(0) wire-catalyzed single…”
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Accelerated Ten-Gram-Scale Synthesis of One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer 97
Published in Biomacromolecules (14-10-2024)“…One-component multifunctional sequence-defined ionizable amphiphilic Janus dendrimers (IAJDs) were discovered in our laboratories in 2021 to represent a new…”
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Bridging organic, molecular, macromolecular, supramolecular and biological sciences to create functions via fluorine chemistry and fluorinated reagents
Published in Giant (Oxford, England) (01-12-2023)“…•Aryl fluorides in SNAr and SRN1, Ni-catalyzed cross-coupling, and size-specific cyclizations (82/92).•Orthogonal cross-coupling of aryl fluorides and simplest…”
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Catalytic effect of DMSO in metal‐catalyzed radical polymerization mediated by disproportionation facilitates living and immortal radical polymerizations
Published in Journal of polymer science (2020) (15-05-2023)“…DMSO, an interesting solvent for copper‐catalyzed living radical polymerization (LRP) mediated by disproportionation, does not exhibit the greatest…”
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14
Replacing Cu(II)Br2 with Me6‑TREN in Biphasic Cu(0)/TREN Catalyzed SET-LRP Reveals the Mixed-Ligand Effect
Published in Biomacromolecules (13-01-2020)“…The mixed-ligand system consisting of tris(2-aminoethyl)amine (TREN) and tris(2-dimethylaminoethyl)amine (Me6-TREN) during the Cu(0) wire-catalyzed single…”
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15
Resolving the incompatibility between SET-LRP and non-disproportionating solvents
Published in Giant (Oxford, England) (01-08-2023)“…•Single electron transfer living radical polymerization (49/54).•Single electron transfer degenerative transfer living radical polymerization…”
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Molecular parameters including fluorination program order during hierarchical helical self-organization of self-assembling dendrons
Published in Giant (Oxford, England) (01-08-2022)“…•hierarchical perfluorinated helical column assembly mediated by molecular parameters;•apex molecular parameters such as H-bonding and no-H-bonding;•linear…”
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