Search Results - "Mauritz, R."

Mutations in GANAB, Encoding the Glucosidase IIα Subunit, Cause Autosomal-Dominant Polycystic Kidney and Liver Disease by Porath, Binu, Gainullin, Vladimir G., Cornec-Le Gall, Emilie, Dillinger, Elizabeth K., Heyer, Christina M., Hopp, Katharina, Edwards, Marie E., Madsen, Charles D., Mauritz, Sarah R., Banks, Carly J., Baheti, Saurabh, Reddy, Bharathi, Herrero, José Ignacio, Bañales, Jesús M., Hogan, Marie C., Tasic, Velibor, Watnick, Terry J., Chapman, Arlene B., Vigneau, Cécile, Lavainne, Frédéric, Audrézet, Marie-Pierre, Ferec, Claude, Le Meur, Yannick, Torres, Vicente E., Harris, Peter C.

“…Autosomal-dominant polycystic kidney disease (ADPKD) is a common, progressive, adult-onset disease that is an important cause of end-stage renal disease…”
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Mutations in GANAB, Encoding the Glucosidase IIa Subunit, Cause Autosomal-Dominant Polycystic Kidney and Liver Disease by Porath, Binu, Gainullin, Vladimir G, Gall, Emilie Cornec-Le, Dillinger, Elizabeth K, Heyer, Christina M, Hopp, Katharina, Edwards, Marie E, Madsen, Charles D, Mauritz, Sarah R, Banks, Carly J, Baheti, Saurabh, Reddy, Bharathi, Herrero, José Ignacio, Bañales, Jesús M, Hogan, Marie C, Tasic, Velibor, Watnick, Terry J, Chapman, Arlene B, Vigneau, Cécile, Lavainne, Frédéric, Audrézet, Marie-Pierre, Ferec, Claude, Meur, Yannick Le, Torres, Vicente E, Group, Genkyst Study, Harris, Peter C

“…Autosomal-dominant polycystic kidney disease (ADPKD) is a common, progressive, adult-onset disease that is an important cause of end-stage renal disease…”
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Predictive value of thymidylate synthase and dihydropyrimidine dehydrogenase protein expression on survival in adjuvantly treated stage III colon cancer patients by Westra, J. L., Hollema, H., Schaapveld, M., Platteel, I., Oien, K. A., Keith, W. N., Mauritz, R., Peters, G. J., Buys, C. H. C. M., Hofstra, R. M. W., Plukker, J. Th. M.

“…Background: The predictive value of thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) expression on long-term survival by influencing…”
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Cross-resistance in the 2′,2′-difluorodeoxycytidine (gemcitabine)-resistant human ovarian cancer cell line AG6000 to standard and investigational drugs by Bergman, A.M., Giaccone, G., van Moorsel, C.J.A., Mauritz, R., Noordhuis, P., Pinedo, H.M., Peters, G.J.

“…Gemcitabine (2′-2′-difluorodeoxycytidine; dFdC) is a deoxycytidine analogue which is effective against solid tumours, including lung cancer and ovarian cancer…”
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Polymorphism of the Thymidylate Synthase Gene and Thymidylate Synthase Levels in Colon Cancer Cell Lines and Different Tissues of Colorectal Cancer Patients by Mauritz, R., Beumer, I. J., Marsh, S., McLeod, H. L., Smid, K., van Groeningen, C. J., Pinedo, H. M., Peters, G. J.

“…In a panel of 18 colon cancer cell lines we found that the thymidylate synthase (TS) genotype was related to TS enzyme activity, but not to TS protein and mRNA…”
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Ex vivo activity of methotrexate versus novel antifolate inhibitors of dihydrofolate reductase and thymidylate synthase against childhood leukemia cells by MAURITZ, R, BEKKENK, M. W, ROTS, M. G, PIETERS, R, MINI, E, VAN ZANTWIJK, C. H, VEERMAN, A. J. P, PETERS, G. J, JANSEN, G

“…Leukemic cells of 27 children [14 patients with initial acute lymphoblastic leukemia (iALL), 8 patients with relapsed ALL (rALL), and 5 patients with acute…”
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Exploring nature's plasticity with a flexible probing tool, and finding new ways for its electronic distribution by Beier, M, Baum, M, Rebscher, H, Mauritz, R, Wixmerten, A, Stähler, C F, Müller, M, Stähler, P F

“…Concepts and results are described for the use of a single, but extremely flexible, probing tool to address a wide variety of genomic questions. This is…”
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Comparison of mRNA Expression Levels Determined with TAQ-Man and Competitive Template RT-PCR by Mauritz, R., Schwabe, W., Haeusler, P., Noordhuis, P., Smid, K., McLeod, H. L., Behnke, D., van Groeningen, C. J., Peters, G. J.

“…Two methods for measurement of thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) mRNA expression were compared. Although the relative mRNA…”
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Prothrombotic and Proinflammatory Activities of the β-Hemolytic Group B Streptococcal Pigment by Siemens, Nikolai, Oehmcke-Hecht, Sonja, Hoßmann, Jörn, Skorka, Sebastian B., Nijhuis, Roel H.T., Ruppen, Corinne, Skrede, Steinar, Rohde, Manfred, Schultz, Daniel, Lalk, Michael, Itzek, Andreas, Pieper, Dietmar H., van den Bout, Christiaan J., Claas, Eric C.J., Kuijper, Ed J., Mauritz, Robert, Sendi, Parham, Wunderink, Herman F., Norrby-Teglund, Anna

“…A prominent feature of severe streptococcal infections is the profound inflammatory response that contributes to systemic toxicity. In sepsis the dysregulated…”
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A Structurally Altered Human Reduced Folate Carrier with Increased Folic Acid Transport Mediates a Novel Mechanism of Antifolate Resistance by Jansen, Gerrit, Mauritz, Robert, Drori, Stavit, Sprecher, Hannah, Kathmann, Ietje, Bunni, Marlene, Priest, David G., Noordhuis, Paul, Schornagel, Jan H., Pinedo, Herbert M., Peters, Godefridus J., Assaraf, Yehuda G.

“…CEM/MTX is a subline of human CCRF-CEM leukemia cells which displays >200-fold resistance to methotrexate (MTX) due to defective transport via the reduced…”
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Clustering of Mutations in the First Transmembrane Domain of the Human Reduced Folate Carrier in GW1843U89-resistant Leukemia Cells with Impaired Antifolate Transport and Augmented Folate Uptake by Drori, Stavit, Jansen, Gerrit, Mauritz, Robert, Peters, Godefridus J., Assaraf, Yehuda G.

“…We have studied the molecular basis for the resistance of human CEM leukemia cells to GW1843, a thymidylate synthase inhibitor. GW1843-resistant cells…”
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A probabilistic database approach to autoencoder-based data cleaning by Mauritz, R. R, Nijweide, F. P. J, Goseling, J, van Keulen, M

“…Data quality problems are a large threat in data science. In this paper, we propose a data-cleaning autoencoder capable of near-automatic data quality…”
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Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis by Mauritz, Robert, Peters, Godefridus J, Priest, David G, Assaraf, Yehuda G, Drori, Stavit, Kathmann, Ietje, Noordhuis, Paul, Bunni, Marlene A, Rosowsky, Andre, Schornagel, Jan H, Pinedo, Herbert M, Jansen, Gerrit

“…We determined the mechanisms of resistance of human CCRF-CEM leukemia cells to methotrexate (MTX) vs. those to six novel antifolates: the polyglutamatable…”
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Chronic rhinosinusitis with nasal polyposis and biological agents: the ARIA-ITALY Survey by Lombardi, C, Passalacqua, G, Menzella, F, Mauritz Canevari, R F, Danesi, G, Pusateri, A M, Carone, M, Vancheri, C, Di Marco, F, Micheletto, C, Manzotti, G, Di Gioacchino, M, Bilò, M B, Gelardi, M, Senna, G, Canonica, G W

“…Chronic rhinosinusitis (CRS) is an inflammatory disease that affects the nasal mucosa and the paranasal sinuses. CRS can be associated by nasal polyposis…”
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Differential Methotrexate Resistance in Childhood T- Versus Common/PreB-Acute Lymphoblastic Leukemia Can Be Measured by an In Situ Thymidylate Synthase Inhibition Assay, But Not by the MTT Assay by Rots, Marianne G., Pieters, Rob, Kaspers, Gert-Jan L., van Zantwijk, Christina H., Noordhuis, Paul, Mauritz, Rob, Veerman, Anjo J.P., Jansen, Gerrit, Peters, Godefridus J.

“…Methotrexate (MTX) is not cytotoxic to patient-derived acute lymphoblastic leukemia (ALL) cells in total-cell-kill assays, such as the…”
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Circumvention of Methotrexate Resistance in Childhood Leukemia Subtypes by Rationally Designed Antifolates by Rots, Marianne G., Pieters, Rob, Peters, Godefridus J., van Zantwijk, Christina H., Mauritz, Rob, Noordhuis, Paul, Willey, James C., Hählen, Karel, Creutzig, Ursula, Janka-Schaub, Gritta, Kaspers, Gertjan J.L., Veerman, Anjo J.P., Jansen, Gerrit

“…Cellular methotrexate (MTX) resistance may cause treatment failure in childhood common/preB-acute lymphoblastic leukemia (c/preB-ALL), T-lineage ALL (T-ALL),…”
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Comparison of mRNA expression levels determined with TaqMan and competitive template RT-PCR by Mauritz, R, Schwabe, W, Haeusler, P, Noordhuis, P, Smid, K, McLeod, H L, Behnke, D, van Groeningen, C J, Peters, G J

“…Two methods for measurement of thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) mRNA expression were compared. Although the relative mRNA…”
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Circumvention of Methotrexate Resistance in Childhood Leukemia Subtypes by Rationally Designed Antifolates by Rots, Marianne G., Pieters, Rob, Peters, Godefridus J., van Zantwijk, Christina H., Mauritz, Rob, Noordhuis, Paul, Willey, James C., Ha¨hlen, Karel, Creutzig, Ursula, Janka-Schaub, Gritta, Kaspers, Gertjan J.L., Veerman, Anjo J.P., Jansen, Gerrit

“…Cellular methotrexate (MTX) resistance may cause treatment failure in childhood common/preB-acute lymphoblastic leukemia (c/preB-ALL), T-lineage ALL (T-ALL),…”
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Regulation of carrier-mediated transport of folates and antifolates in methotrexate-sensitive and-resistant leukemia cells by Jansen, Gerrit, Mauritz, Robert M., Assaraf, Yehuda G., Sprecher, Hannah, Drori, Stavit, Kathmann, Ietje, Westerhof, G.Robbin, Priest, David G., Bunni, Marlene, Pinedo, Herbert M., Schornagel, Jan H., Peters, Godefridus J.

“…Prolonged cell culture of human leukemia cells at folate concentrations in the (sub)physiological range (1–5 n m) rather than at ‘standard’ supraphysiological…”
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Differential Methotrexate Resistance in Childhood T- Versus Common/PreB-Acute Lymphoblastic Leukemia Can Be Measured by an In Situ Thymidylate Synthase Inhibition Assay, But Not by the MTT Assay by Rots, Marianne G., Pieters, Rob, Kaspers, Gert-Jan L., van Zantwijk, Christina H., Noordhuis, Paul, Mauritz, Rob, Veerman, Anjo J.P., Jansen, Gerrit, Peters, Godefridus J.

“…Methotrexate (MTX) is not cytotoxic to patient-derived acute lymphoblastic leukemia (ALL) cells in total-cell-kill assays, such as the…”
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