Search Results - "Maurin, Hervé"

Mu opioid receptor in microglia contributes to morphine analgesic tolerance, hyperalgesia, and withdrawal in mice by Reiss, David, Maduna, Tando, Maurin, Hervé, Audouard, Emilie, Gaveriaux‐Ruff, Claire

“…A major challenge in medicine is developing potent pain therapies without the adverse effects of opiates. Neuroinflammation and in particular microglial…”
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Morphine-induced hyperalgesia involves mu opioid receptors and the metabolite morphine-3-glucuronide by Roeckel, Laurie-Anne, Utard, Valérie, Reiss, David, Mouheiche, Jinane, Maurin, Hervé, Robé, Anne, Audouard, Emilie, Wood, John N., Goumon, Yannick, Simonin, Frédéric, Gaveriaux-Ruff, Claire

“…Opiates are potent analgesics but their clinical use is limited by side effects including analgesic tolerance and opioid-induced hyperalgesia (OIH). The…”
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Regional vulnerability and spreading of hyperphosphorylated tau in seeded mouse brain by Detrez, Jan R., Maurin, Hervé, Van Kolen, Kristof, Willems, Roland, Colombelli, Julien, Lechat, Benoit, Roucourt, Bart, Van Leuven, Fred, Baatout, Sarah, Larsen, Peter, Nuydens, Rony, Timmermans, Jean-Pierre, De Vos, Winnok H.

“…We have exploited whole brain microscopy to map the progressive deposition of hyperphosphorylated tau in intact, cleared mouse brain. We found that the…”
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Increasing brain protein O-GlcNAc-ylation mitigates breathing defects and mortality of Tau.P301L mice by Borghgraef, Peter, Menuet, Clément, Theunis, Clara, Louis, Justin V, Devijver, Herman, Maurin, Hervé, Smet-Nocca, Caroline, Lippens, Guy, Hilaire, Gerard, Gijsen, Harrie, Moechars, Dieder, Van Leuven, Fred

“…The microtubule associated protein tau causes primary and secondary tauopathies by unknown molecular mechanisms. Post-translational O-GlcNAc-ylation of brain…”
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Inflammasome signaling is dispensable for ß-amyloid-induced neuropathology in preclinical models of Alzheimer's disease by Srinivasan, Sahana, Kancheva, Daliya, De Ren, Sofie, Saito, Takashi, Jans, Maude, Boone, Fleur, Vandendriessche, Charysse, Paesmans, Ine, Maurin, Hervé, Vandenbroucke, Roosmarijn E, Hoste, Esther, Voet, Sofie, Scheyltjens, Isabelle, Pavie, Benjamin, Lippens, Saskia, Schwabenland, Marius, Prinz, Marco, Saido, Takaomi, Bottelbergs, Astrid, Movahedi, Kiavash, Lamkanfi, Mohamed, van Loo, Geert

“…Alzheimer's disease (AD) is the most common neurodegenerative disorder affecting memory and cognition. The disease is accompanied by an abnormal deposition of…”
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Early improved and late defective cognition is reflected by dendritic spines in Tau.P301L mice by Kremer, Anna, Maurin, Hervé, Demedts, David, Devijver, Herman, Borghgraef, Peter, Van Leuven, Fred

“…Cognitive demise correlates with progressive brain tauopathy in dementing patients. Improved cognition of young Tau.P301L mice contrasts with dysfunction later…”
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Delta Opioid Receptor in Astrocytes Contributes to Neuropathic Cold Pain and Analgesic Tolerance in Female Mice by Reiss, David, Maurin, Hervé, Audouard, Emilie, Martínez-Navarro, Miriam, Xue, Yaping, Herault, Yann, Maldonado, Rafael, Cabañero, David, Gaveriaux-Ruff, Claire

“…Background : The delta opioid receptor (DOR) contributes to pain control, and a major challenge is the identification of DOR populations that control pain,…”
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Early structural and functional defects in synapses and myelinated axons in stratum lacunosum moleculare in two preclinical models for tauopathy by Maurin, Hervé, Chong, Seon-Ah, Kraev, Igor, Davies, Heather, Kremer, Anna, Seymour, Claire Marie, Lechat, Benoit, Jaworski, Tomasz, Borghgraef, Peter, Devijver, Herman, Callewaert, Geert, Stewart, Michael G, Van Leuven, Fred

“…The stratum lacunosum moleculare (SLM) is the connection hub between entorhinal cortex and hippocampus, two brain regions that are most vulnerable in…”
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Phosphorylation of protein Tau by GSK3β prolongs survival of bigenic Tau.P301L × GSK3β mice by delaying brainstem tauopathy by Crespo-Biel, Natalia, Theunis, Clara, Borghgraef, Peter, Lechat, Benoit, Devijver, Herman, Maurin, Hervé, Van Leuven, Fred

“…Abstract Tau.P301L transgenic mice suffer precocious mortality between ages 8 and 11 months, resulting from upper airway defects caused by tauopathy in…”
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Positive and negative early life experiences differentially modulate long term survival and amyloid protein levels in a mouse model of Alzheimer's disease by Lesuis, Sylvie L, Maurin, Herve, Borghgraef, Peter, Lucassen, Paul J, Van Leuven, Fred, Krugers, Harm J

“…Stress has been implicated as a risk factor for the severity and progression of sporadic Alzheimer's disease (AD). Early life experiences determine stress…”
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Terminal hypothermic Tau.P301L mice have increased Tau phosphorylation independently of glycogen synthase kinase 3α/β by Maurin, Hervé, Lechat, Benoit, Borghgraef, Peter, Devijver, Herman, Jaworski, Tomasz, Van Leuven, Fred

“…The microtubule‐associated protein Tau is responsible for a large group of neurodegenerative disorders, known as tauopathies, including Alzheimer's disease…”
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Tauopathy differentially affects cell adhesion molecules in mouse brain: early down-regulation of nectin-3 in stratum lacunosum moleculare by Maurin, Hervé, Seymour, Claire Marie, Lechat, Benoit, Borghgraef, Peter, Devijver, Herman, Jaworski, Tomasz, Schmidt, Mathias V, Kuegler, Sebastian, Van Leuven, Fred

“…Cell adhesion molecules are important structural substrates, required for synaptic plasticity and synaptogenesis. CAMs differ widely in their expression…”
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Neurological characterization of mice deficient in GSK3α highlight pleiotropic physiological functions in cognition and pathological activity as Tau kinase by Maurin, Hervé, Lechat, Benoit, Dewachter, Ilse, Ris, Laurence, Louis, Justin V, Borghgraef, Peter, Devijver, Herman, Jaworski, Tomasz, Van Leuven, Fred

“…GSK3β is involved in a wide range of physiological functions, and is presumed to act in the pathogenesis of neurological diseases, from bipolar disorder to…”
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Transcriptional upregulation of myelin components in spontaneous myelin basic protein-deficient mice by Staats, Kim A, Pombal, Diana, Schönefeldt, Susann, Van Helleputte, Lawrence, Maurin, Hervé, Dresselaers, Tom, Govaerts, Kristof, Himmelreich, Uwe, Van Leuven, Fred, Van Den Bosch, Ludo, Dooley, James, Humblet-Baron, Stephanie, Liston, Adrian

“…Abstract Myelin is essential for efficient signal transduction in the nervous system comprising of multiple proteins. The intricacies of the regulation of the…”
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Single‐cell analysis of osmoregulation reveals heterogeneity of aquaporin 4 functionality in human astrocytes by Steenberghen, Hugo, Beuckeleer, Sarah De, Hellings, Niels, Somers, Veerle, Breedam, Elise Van, Ponsaerts, Peter, Nuydens, Rony, Maurin, Hervé, Larsen, Peter H., De Vos, Winnok H.

“…The water channel aquaporin 4 (AQP4) contributes to water flow and waste removal across the blood–brain barrier and its levels, organization and localization…”
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Neurological characterization of mice deficient in GSK3[alpha] highlight pleiotropic physiological functions in cognition and pathological activity as Tau kinase by Maurin, Hervñ, Lechat, Benoit, Dewachter, Ilse, Ris, Laurence, Louis, Justin V, Borghgraef, Peter, Devijver, Herman, Jaworski, Tomasz, Van Leuven, Fred

“…Background GSK3[beta] is involved in a wide range of physiological functions, and is presumed to act in the pathogenesis of neurological diseases, from bipolar…”
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Terminal hypothermic T au. P 301 L mice have increased Tau phosphorylation independently of glycogen synthase kinase 3α/β by Maurin, Hervé, Lechat, Benoit, Borghgraef, Peter, Devijver, Herman, Jaworski, Tomasz, Van Leuven, Fred

“…The microtubule‐associated protein Tau is responsible for a large group of neurodegenerative disorders, known as tauopathies, including Alzheimer's disease…”
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P1‐047: Epileptogenicity and precocious mortality of bigenic biat mice that express amyloid and tau by Leuven, Fred, Maurin, Hervé, Kremer, Anna, Chong, Seon-Ah, Crespo-Biel, Natalia, Borghgraef, Peter, Lechat, Benoit, Theunis, Clara, Devijver, Herman, Callewaert, Geert

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Epileptogenicity and precocious mortality of bigenic biat mice that express amyloid and tau by Van Leuven, Fred, Maurin, Hervé, Kremer, Anna, Chong, Seon-Ah, Crespo-Biel, Natalia, Borghgraef, Peter, Lechat, Benoit, Theunis, Clara, Devijver, Herman, Callewaert, Geert

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P2–414: O‐GlcNAc‐ase inhibitor improves the clinical conditions of Alzheimer's disease mice by Borghgraef, Peter, Menuet, Clément, Theunis, Clara, Maurin, Hervé, Devijver, Herman, Lechat, Benoit, Gijsen, Harry, Moechars, Dieder, Hilaire, Gérard, Van Leuven, Fred

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