Search Results - "Maurer, Meghan E"

Preclinical characterization of MTX-101: a novel bispecific CD8 Treg modulator that restores CD8 Treg functions to suppress pathogenic T cells in autoimmune diseases by Gardell, Jennifer L., Maurer, Meghan E., Childs, Monica M., Pham, Minh N., Meengs, Brent, Julien, Susan H., Tan, Cong, Boster, Daniel R., Quach, Phoenicia, Therriault, Jon H., Hermansky, Gleda, Patton, Daniel T., Bowser, Justin, Chen, Alex, Morgan, Nadine N., Gilbertson, Emily A., Bogatzki, Lisa, Encarnacion, Kaelen, McMahan, Catherine J., Crane, Courtney A., Swiderek, Kristine M.

“…Regulatory CD8 T cells (CD8 Treg) are responsible for the selective killing of self-reactive and pathogenic CD4 T cells. In autoimmune disease, CD8 Treg may…”
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Endocytosis of megalin by visceral endoderm cells requires the Dab2 adaptor protein by Maurer, Meghan E, Cooper, Jonathan A

“…Rapid endocytosis of lipoprotein receptors involves NPxY signals contained in their cytoplasmic tails. Several proteins, including ARH and Dab2, can bind these…”
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adaptor protein Dab2 sorts LDL receptors into coated pits independently of AP-2 and ARH by Maurer, Meghan E, Cooper, Jonathan A

“…Clathrin-mediated endocytosis requires cargo-specific adaptor proteins that recognize specific receptors and recruit them into coated pits. ARH [also called…”
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Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter by Hannigan, Adèle, Smith, Paul, Kalna, Gabriela, Lo Nigro, Cristiana, Orange, Clare, O'Brien, Darren I, Shah, Reshma, Syed, Nelofer, Spender, Lindsay C, Herrera, Blanca, Thurlow, Johanna K, Lattanzio, Laura, Monteverde, Martino, Maurer, Meghan E, Buffa, Francesca M, Mann, Jelena, Chu, David C K, West, Catharine M L, Patridge, Max, Oien, Karin A, Cooper, Jonathan A, Frame, Margaret C, Harris, Adrian L, Hiller, Louise, Nicholson, Linda J, Gasco, Milena, Crook, Tim, Inman, Gareth J

“…The cytokine TGF-beta acts as a tumor suppressor in normal epithelial cells and during the early stages of tumorigenesis. During malignant progression, cancer…”
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Bispecific CD8 Treg modulators regulate a novel regulatory CD8 T cell network and eliminate pathogenic CD4 T cells in live cell co-culture system by Gardell, Jennifer L, Crane, Courtney, Bowser, Justin, Fasnacht, Rachael, Julien, Susan, Maurer, Meghan E, Templeton, Megan, Therriault, Jon, Yang, Su Jung, Swiderek, Kristine M

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Epigenetic downregulation of human disabled homolog 2 switches TGF-[Beta] from a tumor suppressor to a tumor promoter by Hannigan, Adèle, Smith, Paul, Kalna, Gabriela, Lo Nigro, Cristiana, Orange, Clare, O'Brien, Darren I, Shah, Reshma, Syed, Nelofer, Spender, Lindsay C, Herrera, Blanca, Thurlow, Johanna K, Lattanzio, Laura, Monteverde, Martino, Maurer, Meghan E, Buffa, Francesca M, Mann, Jelena, Chu, David C K, West, Catharine M L, Patridge, Max, Oien, Karin A, Cooper, Jonathan A, Frame, Margaret C, Harris, Adrian L, Hiller, Louise, Nicholson, Linda J, Gasco, Milena, Crook, Tim, Inman, Gareth J

“…The cytokine TGF-beta acts as a tumor suppressor in normal epithelial cells and during the early stages of tumorigenesis. During malignant progression, cancer…”
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