Association of endothelin-1 and cell surface adhesion molecules levels in patients with systemic sclerosis

Endothelin-1 (ET-1) has been implicated in the pathogenesis of inflammatory and fibrotic diseases, including systemic sclerosis. In addition to modulating vascular tone and extracellular matrix turnover, ET-1 up-regulates cell surface adhesion molecules–intercellular adhesion molecule-1 (ICAM-1) and...

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Bibliographic Details
Published in:	Journal of laboratory medicine Vol. 44; no. 6; pp. 343 - 347
Main Authors:	Mauliūtė, Monika, Rugienė, Rita, Žėkas, Vytautas, Bagdonaitė, Loreta
Format:	Journal Article
Language:	English
Published:	De Gruyter 01-12-2020
Subjects:	endothelin-1 (et-1) intercellular adhesion molecule-1 (icam-1) systemic sclerosis vascular cell adhesion molecule-1 (vcam-1)
Online Access:	Get full text
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Summary:	Endothelin-1 (ET-1) has been implicated in the pathogenesis of inflammatory and fibrotic diseases, including systemic sclerosis. In addition to modulating vascular tone and extracellular matrix turnover, ET-1 up-regulates cell surface adhesion molecules–intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1).The aim of the study was to evaluate the diagnostic value of the detection of ET-1, VCAM-1 and ICAM-1 in the diagnosis of systemic sclerosis.
ISSN:	2567-9430 2567-9449
DOI:	10.1515/labmed-2020-0050