Search Results - "Mauk, M D"

The Cerebellum: A Neuronal Learning Machine? by Raymond, Jennifer L., Lisberger, Stephen G., Mauk, Michael D.

“…Comparison of two seemingly quite different behaviors yields a surprisingly consistent picture of the role of the cerebellum in motor learning. Behavioral and…”
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Cerebellar function: coordination, learning or timing? by Mauk, M D, Medina, J F, Nores, W L, Ohyama, T

“…Theories of cerebellar function have largely involved three ideas: movement coordination, motor learning or timing. New evidence indicates these distinctions…”
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Cerebellar cortex lesions disrupt learning-dependent timing of conditioned eyelid responses by Perrett, SP, Ruiz, BP, Mauk, MD

“…Among the many issues surrounding the involvement of the cerebellum in motor learning, the relative roles of the cerebellar cortex and cerebellar nuclei in…”
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Mechanisms of cerebellar learning suggested by eyelid conditioning by Medina, Javier F, Nores, William L, Ohyama, Tatsuya, Mauk, Michael D

“…Classical eyelid conditioning has been used to great advantage in demonstrating that the cerebellum helps to improve movements through experience, and in…”
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A model of Pavlovian eyelid conditioning based on the synaptic organization of the cerebellum by Mauk, M D, Donegan, N H

“…We present a model based on the synaptic and cellular organization of the cerebellum to derive a diverse range of phenomena observed in Pavlovian eyelid…”
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Distinct LTP induction mechanisms: contribution of NMDA receptors and voltage-dependent calcium channels by Huber, K M, Mauk, M D, Kelly, P T

“…1. Our results indicate that there are two distinct components of long-term potentiation (LTP) induced by the K+ channel blocker tetraethylammonium chloride…”
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An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation by Malenka, Robert C, Kauer, Julie A, Perkel, David J, Mauk, Michael D, Kelly, Paul T, Nicoll, Roger A, Waxham, M. Neal

“…The phenomenon of long-term potentiation (LTP), a long lasting increase in the strength of synaptic transmission which is due to brief, repetitive activation…”
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Classical Conditioning Using Stimulation of the Inferior Olive as the Unconditioned Stimulus by Mauk, Michael D., Steinmetz, Joseph E., Thompson, Richard F.

“…We show that conditioned eyelid responses develop when the unconditioned stimulus is electrical stimulation of the dorsal accessory nucleus of the inferior…”
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Computer simulation of cerebellar information processing by Medina, J F, Mauk, M D

“…Although many functions have been ascribed to the cerebellum, the uniformity of its synaptic organization suggests that a single, characteristic computation…”
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Activity-evoked increases in extracellular potassium modulate presynaptic excitability in the CA1 region of the hippocampus by Poolos, N P, Mauk, M D, Kocsis, J D

“…1. The effects of stimulus-evoked potassium release on the excitability of presynaptic axons were studied in the rat hippocampal slice preparation…”
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Timing Mechanisms in the Cerebellum: Testing Predictions of a Large-Scale Computer Simulation by Medina, Javier F, Garcia, Keith S, Nores, William L, Taylor, Nichole M, Mauk, Michael D

“…We used large-scale computer simulations of eyelid conditioning to investigate how the cerebellum generates and makes use of temporal information. In the…”
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A Mechanism for Savings in the Cerebellum by Medina, Javier F, Garcia, Keith S, Mauk, Michael D

“…The phenomenon of savings (the ability to relearn faster than the first time) is a familiar property of many learning systems. The utility of savings makes its…”
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Retention of classically conditioned eyelid responses following acute decerebration by Mauk, M D, Thompson, R F

“…We show that classically conditioned eyelid responses are retained in albino rabbits following decerebration. The presence of these responses represents…”
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A critical period of protein kinase activity after tetanic stimulation is required for the induction of long-term potentiation by Huber, K M, Mauk, M D, Thompson, C, Kelly, P T

“…A critical period of protein kinase activity required for the induction of long-term potentiation (LTP) was determined in area CA1 or hippocampal slices using…”
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Latent Acquisition of Timed Responses in Cerebellar Cortex by Ohyama, Tatsuya, Mauk, Michael D

“…Evidence indicates that rabbit eyelid conditioning is mediated by plasticity in the interpositus cerebellar nucleus and in cerebellar cortex. Although the…”
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Roles of Cerebellar Cortex and Nuclei in Motor Learning: Contradictions or Clues? by Mauk, Michael D.

“…The cerebellum, with its relatively simple and regular synaptic organization, has yielded much about its contribution to brain function and its internal…”
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Simulations of Cerebellar Motor Learning: Computational Analysis of Plasticity at the Mossy Fiber to Deep Nucleus Synapse by Medina, Javier F, Mauk, Michael D

“…We question the widely accepted assumption that a molecular mechanism for long-term expression of synaptic plasticity is sufficient to explain the persistence…”
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Glutamate iontophoresis induces long-term potentiation in the absence of evoked presynaptic activity by Cormier, R J, Mauk, M D, Kelly, P T

“…Protocols that induce long-term potentiation (LTP) typically involve afferent stimulation. We tested the hypothesis that LTP induction does not require…”
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Pharmacological analysis of cerebellar contributions to the timing and expression of conditioned eyelid responses by Garcia, Keith S, Mauk, Michael D

“…Contradictory results have been reported regarding the effects of cerebellar cortex lesions on the expression of conditioned eyelid responses—either no effect,…”
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Calcium/calmodulin-dependent protein kinase II regulates hippocampal synaptic transmission by Waxham, M N, Malenka, R C, Kelly, P T, Mauk, M D

“…Extracellular application of protein kinase inhibitors was used to examine the role of calcium/calmodulin-dependent protein kinase II (CaM-KII) in synaptic…”
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