Search Results - "Maughan, Tim S"

Mismatch repair status and BRAF mutation status in metastatic colorectal cancer patients: a pooled analysis of the CAIRO, CAIRO2, COIN, and FOCUS studies by Venderbosch, Sabine, Nagtegaal, Iris D, Maughan, Tim S, Smith, Christopher G, Cheadle, Jeremy P, Fisher, David, Kaplan, Richard, Quirke, Philip, Seymour, Matthew T, Richman, Susan D, Meijer, Gerrit A, Ylstra, Bauke, Heideman, Danielle A M, de Haan, Anton F J, Punt, Cornelis J A, Koopman, Miriam

“…To determine the prevalence and prognostic value of mismatch repair (MMR) status and its relation to BRAF mutation (BRAF(MT)) status in metastatic colorectal…”
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New role of fat-free mass in cancer risk linked with genetic predisposition by Harris, Benjamin H. L., Di Giovannantonio, Matteo, Zhang, Ping, Harris, David A., Lord, Simon R., Allen, Naomi E., Maughan, Tim S., Bryant, Richard J., Harris, Adrian L., Bond, Gareth L., Buffa, Francesca M.

“…Cancer risk is associated with the widely debated measure body mass index (BMI). Fat mass and fat-free mass measurements from bioelectrical impedance may…”
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NRF2 Mediates Therapeutic Resistance to Chemoradiation in Colorectal Cancer through a Metabolic Switch by O'Cathail, Séan M, Wu, Chieh-Hsi, Thomas, Rachael, Hawkins, Maria A, Maughan, Tim S, Lewis, Annabelle

“…Radiation resistance is a significant clinical problem in rectal cancer treatment, the mechanisms of which are poorly understood. NRF2 signalling is known to…”
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The Challenge of Combining Chemo- and Radiotherapy with Checkpoint Kinase Inhibitors by van Bijsterveldt, Linda, Durley, Samuel C, Maughan, Tim S, Humphrey, Timothy C

“…Preclinical models of cancer have demonstrated enhanced efficacy of cell-cycle checkpoint kinase inhibitors when used in combination with genotoxic agents…”
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Immune status is prognostic for poor survival in colorectal cancer patients and is associated with tumour hypoxia by Craig, Stephanie G., Humphries, Matthew P., Alderdice, Matthew, Bingham, Victoria, Richman, Susan D., Loughrey, Maurice B., Coleman, Helen G., Viratham-Pulsawatdi, Amelie, McCombe, Kris, Murray, Graeme I., Blake, Andrew, Domingo, Enric, Robineau, James, Brown, Louise, Fisher, David, Seymour, Matthew T., Quirke, Phil, Bankhead, Peter, McQuaid, Stephen, Lawler, Mark, McArt, Darragh G., Maughan, Tim S., James, Jacqueline A., Salto-Tellez, Manuel

“…Background Immunohistochemical quantification of the immune response is prognostic for colorectal cancer (CRC). Here, we evaluate the suitability of…”
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FOCUS4 biomarker laboratories: from the benefits to the practical and logistical issues faced during 6 years of centralised testing by Richman, Susan D, Hemmings, Gemma, Roberts, Helen, Gallop, Niall, Dodds, Rachel, Wilkinson, Lyndsay, Davis, Jonathan, White, Rhian, Yates, Emma, Jasani, Bharat, Brown, Louise, Maughan, Tim S, Butler, Rachel, Quirke, Philip, Adams, Richard

“…FOCUS4 was a phase II/III umbrella trial, recruiting patients with advanced or metastatic colorectal cancer, between 2014 and 2020. Molecular profiling of…”
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Standard or high dose chemoradiotherapy, with or without the protease inhibitor nelfinavir, in patients with locally advanced pancreatic cancer: The phase 1/randomised phase 2 SCALOP-2 trial by Mukherjee, Somnath, Qi, Cathy, Shaw, Rachel, Jones, Christopher M., Bridgewater, John A., Radhakrishna, Ganesh, Patel, Neel, Holmes, Jane, Virdee, Pradeep S., Tranter, Bethan, Parsons, Philip, Falk, Stephen, Wasan, Harpreet S., Ajithkumar, Thankamma V., Holyoake, Daniel, Roy, Rajarshi, Scott-Brown, Martin, Hurt, Christopher N., O’Neill, Eric, Sebag-Montefiore, David, Maughan, Tim S., Hawkins, Maria A., Corrie, Pippa

“…The multi-centre two-stage SCALOP-2 trial (ISRCTN50083238) assessed whether dose escalation of consolidative chemoradiotherapy (CRT) or concurrent…”
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Pathological grading of regression following neoadjuvant chemoradiation therapy: the clinical need is now by MacGregor, Tom P, Maughan, Tim S, Sharma, Ricky A

“…Neoadjuvant chemoradiotherapy for locally advanced rectal cancer has been shown to decrease rates of local recurrence and more than double the rate of…”
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Stratification to Neoadjuvant Radiotherapy in Rectal Cancer by Regimen and Transcriptional Signatures by Mahmood, Umair, Blake, Andrew, Rathee, Sanjay, Samuel, Leslie, Murray, Graeme, Sebag-Montefiore, David, Gollins, Simon, West, Nicholas P, Begum, Rubina, Bach, Simon P, Richman, Susan D, Quirke, Phil, Redmond, Keara L, Salto-Tellez, Manuel, Koelzer, Viktor H, Leedham, Simon J, Tomlinson, Ian, Dunne, Philip D, Buffa, Francesca M, Maughan, Tim S, Domingo, Enric

“…Response to neoadjuvant radiotherapy (RT) in rectal cancer has been associated with immune and stromal features that are captured by transcriptional…”
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Patterns of progression, treatment of progressive disease and post-progression survival in the New EPOC study by Pugh, Siân A, Bowers, Megan, Ball, Alexandre, Falk, Stephen, Finch-Jones, Meg, Valle, Juan W, O'Reilly, Derek A, Siriwardena, Ajith K, Hornbuckle, Joanne, Rees, Myrddin, Rees, Charlotte, Iveson, Tim, Hickish, Tamas, Maishman, Tom, Stanton, Louise, Dixon, Elizabeth, Corkhill, Andrea, Radford, Mike, Garden, O James, Cunningham, David, Maughan, Tim S, Bridgewater, John A, Primrose, John N

“…Background: The addition of cetuximab (CTX) to perioperative chemotherapy (CT) for operable colorectal liver metastases resulted in a shorter progression-free…”
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Cetuximab Is Contraindicated in the Perioperative Treatment of Colorectal Liver Metastases by Primrose, John N, Cunningham, David, Garden, O James, Maughan, Tim S, Pugh, Siân A, Stanton, Louise, Falk, Stephen J, Rees, Myrddin, Finch-Jones, Meg, Valle, Juan W, O'Reilly, Derek, Hornbuckle, Joanne, Hickish, Tamas, Bridgewater, John A

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The clinical impact of expert pathological review on lymphoma management: a regional experience by Lester, Jason F., Dojcinov, Stefan D., Attanoos, Richard L., O'Brien, Ciaran J., Maughan, Tim S., Toy, Elizabeth T., Poynton, Chris H.

“…The All Wales Lymphoma Panel (AWLP) was established in January 1998 to provide a central expert pathological review service for district general hospital…”
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Genome‐wide association study and meta‐analysis in Northern European populations replicate multiple colorectal cancer risk loci by Tanskanen, Tomas, van den Berg, Linda, Välimäki, Niko, Aavikko, Mervi, Ness‐Jensen, Eivind, Hveem, Kristian, Wettergren, Yvonne, Bexe Lindskog, Elinor, Tõnisson, Neeme, Metspalu, Andres, Silander, Kaisa, Orlando, Giulia, Law, Philip J., Tuupanen, Sari, Gylfe, Alexandra E., Hänninen, Ulrika A., Cajuso, Tatiana, Kondelin, Johanna, Sarin, Antti‐Pekka, Pukkala, Eero, Jousilahti, Pekka, Salomaa, Veikko, Ripatti, Samuli, Palotie, Aarno, Järvinen, Heikki, Renkonen‐Sinisalo, Laura, Lepistö, Anna, Böhm, Jan, Mecklin, Jukka‐Pekka, Al‐Tassan, Nada A., Palles, Claire, Martin, Lynn, Barclay, Ella, Tenesa, Albert, Farrington, Susan M., Timofeeva, Maria N., Meyer, Brian F., Wakil, Salma M., Campbell, Harry, Smith, Christopher G., Idziaszczyk, Shelley, Maughan, Tim S., Kaplan, Richard, Kerr, Rachel, Kerr, David, Buchanan, Daniel D., Win, Aung K., Hopper, John, Jenkins, Mark A., Newcomb, Polly A., Gallinger, Steve, Conti, David, Schumacher, Fredrick R., Casey, Graham, Cheadle, Jeremy P., Dunlop, Malcolm G., Tomlinson, Ian P., Houlston, Richard S., Palin, Kimmo, Aaltonen, Lauri A.

“…Genome‐wide association studies have been successful in elucidating the genetic basis of colorectal cancer (CRC), but there remains unexplained variability in…”
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