Search Results - "Maughan, D W"

Alterations of Myocardial Dynamic Stiffness Implicating Abnormal Crossbridge Function in Human Mitral Regurgitation Heart Failure by Mulieri, L A, Barnes, W, Leavitt, B J, Ittleman, F P, LeWinter, M M, Alpert, N R, Maughan, D W

“…Mitral regurgitation (MR) causes ventricular dilation, a blunted myocardial force-frequency relation, and increased crossbridge force-time integral (FTI). The…”
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In Vivo X-Ray Diffraction of Indirect Flight Muscle from Drosophila melanogaster by Irving, T.C., Maughan, D.W.

“…Small-angle x-ray diffraction from isolated muscle preparations is commonly used to obtain time-resolved structural information during contraction. We extended…”
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On the composition of the cytosol of relaxed skeletal muscle of the frog by Godt, R E, Maughan, D W

“…This review summarizes a variety of estimates for the concentrations of the principal cytosolic constituents in frog skeletal muscle. From these estimates…”
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Targeted Ablation of the Murine alpha-Tropomyosin Gene by Blanchard, Edward M, Iizuka, Kenji, Christe, Michael, Conner, David A, Geisterfer-Lowrance, Anja, Schoen, Frederick J, Maughan, David W, Seidman, Christine E, Seidman, J.G

“…We created a mouse that lacks a functional alpha-tropomyosin gene using gene targeting in embryonic stem cells and blastocyst-mediated transgenesis. Homozygous…”
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Ion-specific and general ionic effects on contraction of skinned fast-twitch skeletal muscle from the rabbit by ANDREWS, M. A. W, MAUGHAN, D. W, NOSEK, T. M, GODT, R. E

“…We used single fibers from rabbit psoas muscle, chemically skinned with Triton X-100 nonionic detergent, to determine the salts best suited for adjusting ionic…”
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Cross-bridge movement in rat cardiac muscle as a function of calcium concentration by Matsubara, I, Maughan, D W, Saeki, Y, Yagi, N

“…1. By applying the X-ray diffraction method to chemically skinned papillary muscles of the rat, the transfer of myosin heads from the thick to the thin…”
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Fourier analysis of wing beat signals: assessing the effects of genetic alterations of flight muscle structure in Diptera by Hyatt, C.J., Maughan, D.W.

“…A method for determining and analyzing the wing beat frequency in Diptera is presented. This method uses an optical tachometer to measure Diptera wing movement…”
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Role of the elastic protein projectin in stretch activation and work output of Drosophila flight muscles by Vigoreaux, J O, Moore, J R, Maughan, D W

“…We examine how the stretch activation response of the Drosophila indirect flight muscles (IFM) is affected by the projectin mutation bentDominant. IFM from…”
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Equilibrium distribution of ions in a muscle fiber by Maughan, D.W., Godt, R.E.

“…We have developed a mathematical description of the equilibrium (Donnan) distribution of mobile ions between two phases containing fixed charges. This differs…”
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Approximating the isometric force-calcium relation of intact frog muscle using skinned fibers by Maughan, D.W., Molloy, J.E., Brotto, M.A., Godt, R.E.

“…In previous papers we used estimates of the composition of frog muscle and calculations involving the likely fixed charge density in myofibrils to propose…”
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Mutations that affect flightin expression in Drosophila alter the viscoelastic properties of flight muscle fibers by Henkin, Josh A, Maughan, David W, Vigoreaux, Jim O

“…Striated muscles across phyla share a highly conserved sarcomere design yet exhibit broad diversity in contractile velocity, force, power output, and…”
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Morphology and Transverse Stiffness of Drosophila Myofibrils Measured by Atomic Force Microscopy by Nyland, Lori R., Maughan, David W.

“…Atomic force microscopy was used to investigate the surface morphology and transverse stiffness of myofibrils from Drosophila indirect flight muscle exposed to…”
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Phosphorylation-dependent power output of transgenic flies: an integrated study by Dickinson, M.H., Hyatt, C.J., Lehmann, F.O., Moore, J.R., Reedy, M.C., Simcox, A., Tohtong, R., Vigoreaux, J.O., Yamashita, H., Maughan, D.W.

“…We examine how the structure and function of indirect flight muscle (IFM) and the entire flight system of Drosophila melanogaster are affected by…”
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A non-flight muscle isoform of Drosophila tropomyosin rescues an indirect flight muscle tropomyosin mutant by MILLER, R. C, SCHAAF, R, MAUGHAN, D. W, TANSEY, T. R

“…The tropomyosin I(TmI) gene of Drosophila melanogaster encodes two isoforms of tropomyosin. The Ifm-TmI isoform is expressed only in indirect flight and jump…”
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The Effect of Removing the N-Terminal Extension of the Drosophila Myosin Regulatory Light Chain upon Flight Ability and the Contractile Dynamics of Indirect Flight Muscle by Moore, Jeffrey R., Dickinson, Michael H., Vigoreaux, Jim O., Maughan, David W.

“…The Drosophila myosin regulatory light chain (DMLC2) is homologous to MLC2s of vertebrate organisms, except for the presence of a unique 46-amino acid…”
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Active force as a function of filament spacing in crayfish skinned muscle fibers by APRIL, E. W, MAUGHAN, D. W

“…Filament spacing is shown to have a pronounced effect on active force in skinned striated muscle fibers of crayfish. At constant filament overlap and constant…”
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Stretch and radial compression studies on relaxed skinned muscle fibers of the frog by Maughan, D.W., Godt, R.E.

“…The influence of stretch and radial compression on the width of mechanically skinned fibers from the semitendinosus muscle of the frog (R. pipiens) was…”
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Protein Osmotic Pressure and the State of Water in Frog Myoplasm by Maughan, David W., Godt, Robert E.

“…We measured the osmotic pressure of diffusible myoplasmic proteins in frog ( Rana temporaria) skeletal muscle fibers by using single Sephadex beads as…”
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Radial forces within muscle fibers in rigor by Maughan, D W, Godt, R E

“…Considering the widely accepted cross-bridge model of muscle contraction (Huxley. 1969. Science [Wash. D. C.]. 164:1356-1366), one would expect that attachment…”
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Force transient time course in heart muscle with high and low V1 to V3 myosin isoenzyme ratio by Berman, M R, Lord, C C, Maughan, D W

“…Values of mechanical and biochemical indicators of muscle performance measured in heart muscle having mostly the V1 isoenzyme of myosin are different than…”
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