Search Results - "Maugeais, Cyrille"

Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease by Wright, Matthew B., Varona Santos, Javier, Kemmer, Christian, Maugeais, Cyrille, Carralot, Jean-Philippe, Roever, Stephan, Molina, Judith, Ducasa, G. Michelle, Mitrofanova, Alla, Sloan, Alexis, Ahmad, Anis, Pedigo, Christopher, Ge, Mengyuan, Pressly, Jeffrey, Barisoni, Laura, Mendez, Armando, Sgrignani, Jacopo, Cavalli, Andrea, Merscher, Sandra, Prunotto, Marco, Fornoni, Alessia

“…Impaired cellular cholesterol efflux is a key factor in the progression of renal, cardiovascular, and autoimmune diseases. Here we describe a class of…”
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ATP-binding cassette A1 deficiency causes cardiolipin-driven mitochondrial dysfunction in podocytes by Ducasa, G Michelle, Mitrofanova, Alla, Mallela, Shamroop K, Liu, Xiaochen, Molina, Judith, Sloan, Alexis, Pedigo, Christopher E, Ge, Mengyuan, Santos, Javier Varona, Hernandez, Yanio, Kim, Jin-Ju, Maugeais, Cyrille, Mendez, Armando J, Nair, Viji, Kretzler, Matthias, Burke, George W, Nelson, Robert G, Ishimoto, Yu, Inagi, Reiko, Banerjee, Santanu, Liu, Shaoyi, Szeto, Hazel H, Merscher, Sandra, Fontanesi, Flavia, Fornoni, Alessia

“…Fibroblasts from patients with Tangier disease carrying ATP-binding cassette A1 (ABCA1) loss-of-function mutations are characterized by cardiolipin…”
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Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration by Storti, Federica, Klee, Katrin, Todorova, Vyara, Steiner, Regula, Othman, Alaa, van der Velde-Visser, Saskia, Samardzija, Marijana, Meneau, Isabelle, Barben, Maya, Karademir, Duygu, Pauzuolyte, Valda, Boye, Sanford L, Blaser, Frank, Ullmer, Christoph, Dunaief, Joshua L, Hornemann, Thorsten, Rohrer, Lucia, den Hollander, Anneke, von Eckardstein, Arnold, Fingerle, Jürgen, Maugeais, Cyrille, Grimm, Christian

“…Age-related macular degeneration (AMD) is a progressive disease of the retinal pigment epithelium (RPE) and the retina leading to loss of central vision…”
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An in silico model of retinal cholesterol dynamics (RCD model): insights into the pathophysiology of dry AMD by Zekavat, Seyedeh Maryam, Lu, James, Maugeais, Cyrille, Mazer, Norman A.

“…We developed an in silico mathematical model of retinal cholesterol (Ch) dynamics (RCD) to quantify the physiological rate of Ch turnover in the rod outer…”
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A mega-analysis of expression quantitative trait loci (eQTL) provides insight into the regulatory architecture of gene expression variation in liver by Strunz, Tobias, Grassmann, Felix, Gayán, Javier, Nahkuri, Satu, Souza-Costa, Debora, Maugeais, Cyrille, Fauser, Sascha, Nogoceke, Everson, Weber, Bernhard H. F.

“…Genome-wide association studies (GWAS) have identified numerous genetic variants in the human genome associated with diseases and traits. Nevertheless, for…”
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Dalcetrapib and anacetrapib differently impact HDL structure and function in rabbits and monkeys by Brodeur, Mathieu R., Rhainds, David, Charpentier, Daniel, Mihalache-Avram, Teodora, Mecteau, Mélanie, Brand, Geneviève, Chaput, Evelyne, Perez, Anne, Niesor, Eric J., Rhéaume, Eric, Maugeais, Cyrille, Tardif, Jean-Claude

“…Inhibition of cholesteryl ester transfer protein (CETP) increases HDL cholesterol (HDL-C) levels. However, the circulating CETP level varies and the impact of…”
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Modulating cholesteryl ester transfer protein activity maintains efficient pre-β-HDL formation and increases reverse cholesterol transport[S] by Niesor, Eric J., Magg, Christine, Ogawa, Naoto, Okamoto, Hiroshi, von der Mark, Elisabeth, Matile, Hugues, Schmid, Georg, Clerc, Roger G., Chaput, Evelyne, Blum-Kaelin, Denise, Huber, Walter, Thoma, Ralf, Pflieger, Philippe, Kakutani, Makoto, Takahashi, Daisuke, Dernick, Gregor, Maugeais, Cyrille

“…The mechanism by which cholesteryl ester transfer protein (CETP) activity affects HDL metabolism was investigated using agents that selectively target CETP…”
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Dalcetrapib and anacetrapib increase apolipoprotein E-containing HDL in rabbits and humans by Brodeur, Mathieu R., Rhainds, David, Charpentier, Daniel, Boulé, Marie, Mihalache-Avram, Téodora, Mecteau, Mélanie, Brand, Geneviève, Pedneault-Gagnon, Valérie, Fortier, Annik, Niesor, Eric J., Rhéaume, Eric, Maugeais, Cyrille, Tardif, Jean-Claude

“…The large HDL particles generated by administration of cholesteryl ester transfer protein inhibitors (CETPi) remain poorly characterized, despite their…”
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Characterization of the lipolytic activity of endothelial lipase by McCoy, Mary G., Sun, Gwo-Shing, Marchadier, Dawn, Maugeais, Cyrille, Glick, Jane M., Rader, Daniel J.

“…Endothelial lipase (EL) is a new member of the triglyceride lipase gene family previously reported to have phospholipase activity. Using radiolabeled lipid…”
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Scavenger Receptor BI-mediated Selective Uptake Is Required for the Remodeling of High Density Lipoprotein by Endothelial Lipase by Nijstad, Niels, Wiersma, Harmen, Gautier, Thomas, van der Giet, Markus, Maugeais, Cyrille, Tietge, Uwe J.F.

“…Endothelial lipase (EL) is a negative regulator of high density lipoprotein (HDL) cholesterol plasma levels, and scavenger receptor BI (SR-BI) is involved in…”
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Lipoprotein [a] is cleared from the plasma primarily by the liver in a process mediated by apolipoprotein [a] by Cain, William J, Millar, John S, Himebauch, Adam S, Tietge, Uwe J. F, Maugeais, Cyrille, Usher, David, Rader, Daniel J

“…The cellular and molecular mechanisms responsible for lipoprotein [a] (Lp[a]) catabolism are unknown. We examined the plasma clearance of Lp[a] and LDL in mice…”
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Dose-dependent acceleration of high-density lipoprotein catabolism by endothelial lipase by MAUGEAIS, Cyrille, TIETGE, Uwe J. F, BROEDL, Uli C, MARCHADIER, Dawn, CAIN, William, MCCOY, Mary G, LUND-KATZ, Sissel, GLICK, Jane M, RADER, Daniel J

“…Factors that regulate the metabolism of HDL and apolipoprotein A-I (apoA-I) are incompletely understood. Overexpression of endothelial lipase (EL) markedly…”
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Discovery of tetrahydro-cyclopenta[b]indole as selective LXRs modulator by RATNI, Hassen, BLUM-KAELIN, Denise, DEHMLOW, Henrietta, HARTMAN, Peter, JABLONSKI, Philippe, MASCIADRI, Raffaello, MAUGEAIS, Cyrille, PATINY-ADAM, Angelique, PANDAY, Narendra, WRIGHT, Matthew

“…A series of tetrahydro-cyclopenta[b]indoles modulating the activity of the liver-X-receptor (LXR) were derived from a high throughput screening hit. The…”
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Multidimensional profiling of plasma lipoproteins by size exclusion chromatography followed by reverse-phase protein arrays by Dernick, Gregor, Obermüller, Stefan, Mangold, Cyrill, Magg, Christine, Matile, Hugues, Gutmann, Oliver, von der Mark, Elisabeth, Handschin, Corinne, Maugeais, Cyrille, Niesor, Eric J.

“…The composition of lipoproteins and the association of proteins with various particles are of much interest in the context of cardiovascular disease. Here, we…”
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Overexpression of Secretory Phospholipase A2 Causes Rapid Catabolism and Altered Tissue Uptake of High Density Lipoprotein Cholesteryl Ester and Apolipoprotein A-I by Tietge, Uwe J.F., Maugeais, Cyrille, Cain, William, Grass, David, Glick, Jane M., de Beer, Frederick C., Rader, Daniel J.

“…Plasma levels of high density lipoprotein (HDL) cholesterol and its major protein component apolipoprotein (apo) A-I are significantly reduced in both acute…”
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Endothelial Lipase Promotes the Catabolism of ApoB-Containing Lipoproteins by Broedl, Uli C, Maugeais, Cyrille, Millar, John S, Jin, Weijun, Moore, Ryan E, Fuki, Ilia V, Marchadier, Dawn, Glick, Jane M, Rader, Daniel J

“…Endothelial lipase (EL) has been found to be a key enzyme in high-density lipoprotein (HDL) metabolism in mice, leading to the concept that inhibition of EL…”
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Hepatic overexpression of microsomal triglyceride transfer protein (MTP) results in increased in vivo secretion of VLDL triglycerides and apolipoprotein B by Tietge, U J, Bakillah, A, Maugeais, C, Tsukamoto, K, Hussain, M, Rader, D J

“…The microsomal triglyceride transfer protein (MTP) is essential for the hepatic secretion of apolipoprotein (apo) B-containing lipoproteins. Previous studies…”
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Effects of Nonlipolytic Ligand Function of Endothelial Lipase on High Density Lipoprotein Metabolism in Vivo by Broedl, Uli C., Maugeais, Cyrille, Marchadier, Dawn, Glick, Jane M., Rader, Daniel J.

“…Endothelial lipase (EL) influences high density lipoprotein (HDL) metabolism in vivo and mediates bridging and uptake of HDL particles independent of its…”
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Reduction of Isoprostanes and Regression of Advanced Atherosclerosis by Apolipoprotein E by Tangirala, Rajendra K., Praticó, Domenico, FitzGerald, Garret A., Chun, Sam, Tsukamoto, Kazuhisa, Maugeais, Cyrille, Usher, David C., Puré, Ellen, Rader, Daniel J.

“…Apolipoprotein E is a multifunctional protein synthesized by hepatocytes and macrophages. Plasma apoE is largely liver-derived and known to regulate…”
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Dalcetrapib Does Not Prevent CETP-Induced Pre-β1-HDL Formation, a Potential Marker of HDL Functionality, in Human Plasma In Vitro and in Treated Patients by Niesor, Eric J., PhD, Maugeais, Cyrille, PhD, Dernick, Gregor, PhD, von der Mark, Elisabeth, MSc, Kallend, David, MB, BS

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