Search Results - "Mauck, Christine K"

As the world grows: contraception in the 21st century by Aitken, R John, Baker, Mark A, Doncel, Gustavo F, Matzuk, Martin M, Mauck, Christine K, Harper, Michael J K

“…Contraceptives that are readily available and acceptable are required in many poorer countries to reduce population growth and in all countries to prevent…”
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Contraceptive efficacy should primarily be measured using life table pregnancy rates by Mauck, Christine K., Dart, Clint, Thurman, Andrea, Creinin, Mitchell D.

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The postcoital test in the development of new vaginal contraceptives by Mauck, Christine K, Vincent, Kathleen L

“…Postcoital tests (PCTs) have been used for over a century in the clinical evaluation of infertile couples, and for nearly 70 years in the evaluation of new…”
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A Phase 1 pharmacokinetic study of a single-dose bioadhesive clindamycin 2% gel for bacterial vaginosis by Mauck, Christine K, Atiee, George J, McCulloh, Jennifer, Reynolds, Laurie, Zack, Nadene, Friend, David R

“…Abstract Objectives To evaluate pharmacokinetics (PK) of a single dose of an investigational 2% clindamycin phosphate vaginal gel in healthy women by…”
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Use of contraceptive depot medroxyprogesterone acetate is associated with impaired cervicovaginal mucosal integrity by Zalenskaya, Irina A, Chandra, Neelima, Yousefieh, Nazita, Fang, Xi, Adedipe, Oluwatosin E, Jackson, Suzanne S, Anderson, Sharon M, Mauck, Christine K, Schwartz, Jill L, Thurman, Andrea R, Doncel, Gustavo F

“…Injectable depot medroxyprogesterone acetate (DMPA) is one of the most popular contraception methods in areas of high HIV seroprevalence. Evidence is…”
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Contraceptive Efficacy, Safety, Fit, and Acceptability of a Single-Size Diaphragm Developed With End-User Input by Schwartz, Jill L., Weiner, Debra H., Lai, Jaim Jou, Frezieres, Ron G., Creinin, Mitchell D., Archer, David F., Bradley, Lynn, Barnhart, Kurt T., Poindexter, Alfred, Kilbourne-Brook, Maggie, Callahan, Marianne M., Mauck, Christine K.

“…OBJECTIVE:To estimate contraceptive efficacy, safety, acceptability, and fit of a single-size diaphragm used with contraceptive gel. METHODS:We conducted a…”
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A Phase I Randomized Postcoital Testing and Safety Study of the Caya Diaphragm used with 3% Nonoxynol-9 gel, ContraGel, or No Gel by Mauck, Christine K, Brache, Vivian, Kimble, Thomas, Thurman, Andrea, Cochon, Leila, Littlefield, Sarah, Linton, Kim, Doncel, Gustavo F, Schwartz, Jill L

“…Abstract Objectives The Caya® Diaphragm is a newly approved single-size, non-latex diaphragm. Contragel® is a personal lubricant containing lactic acid…”
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Biomarkers of Semen Exposure by Mauck, Christine K.

“…Biomarkers of semen exposure have historically played their most important role in forensics, i.e., determining whether ejaculation took place in the course of…”
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The effect of one injection of Depo-Provera® on the human vaginal epithelium and cervical ectopy by Mauck, Christine K, Callahan, Marianne Morse, Baker, Jay, Arbogast, Kathleen, Veazey, Ron, Stock, Richard, Pan, Zhiying, Morrison, Charles S, Chen-Mok, Mario, Archer, David F, Gabelnick, Henry L

“…Two studies in rhesus monkeys have shown that progesterone implants, Depo-Provera® and Norplant®, were associated with vaginal thinning. Progesterone implants…”
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Comparison of self-reported female condom failure and biomarker-confirmed semen exposure by Walsh, Terri L., Snead, Margaret C., St. Claire, Breione J., Schwartz, Jill L., Mauck, Christine K., Frezieres, Ron G., Blithe, Diana L., Archer, David F., Barnhart, Kurt T., Jensen, Jeffrey T., Nelson, Anita L., Thomas, Michael A., Wan, Livia S., Weaver, Mark A.

“…To investigate whether rates of self-reported Woman's Condom (WC) clinical failure and semen exposure from a functionality study are comparable to results from…”
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Dyeing to Know: The Use of Vaginal Applicator Staining and Other Techniques to Assess Adherence to Product Use in Microbicide Trials by Mauck, Christine K., Schwartz, Jill L.

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Twice-Daily Application of HIV Microbicides Alters the Vaginal Microbiota by Ravel, Jacques, Gajer, Pawel, Fu, Li, Mauck, Christine K., Koenig, Sara S. K., Sakamoto, Joyce, Motsinger-Reif, Alison A., Doncel, Gustavo F., Zeichner, Steven L.

“…Vaginal HIV microbicides offer great promise in preventing HIV transmission, but failures of phase 3 clinical trials, in which microbicide-treated subjects had…”
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Biomarkers of semen in the vagina: applications in clinical trials of contraception and prevention of sexually transmitted pathogens including HIV by Mauck, Christine K, Doncel, Gustavo F

“…Abstract Biomarkers of vaginal exposure to semen, long used in forensic medicine, are now becoming important in the development of vaginal microbicides to…”
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Using Objective Markers to Assess Participant Behavior in HIV Prevention Trials of Vaginal Microbicides by MAUCK, Christine K, VAN DER STRATEN, Ariane

“…The need to verify participant behavior exists in any study in which behavior may affect outcomes. In vaginal microbicide trials, the act of having sex and the…”
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Baseline variation and associations between subject characteristics and five cytokine biomarkers of vaginal safety among healthy non-pregnant women in microbicide trials by Fichorova, Raina N., Lai, Jaim-Jou, Schwartz, Jill L., Weiner, Debra H., Mauck, Christine K., Callahan, Marianne M.

“…► The vaginal cytokine baseline varied by contraceptive method in healthy premenopausal women. ► No differences were found by race when controlled for method…”
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Toward early safety alert endpoints: exploring biomarkers suggestive of microbicide failure by Mauck, Christine K, Lai, Jaim Jou, Weiner, Debra H, Chandra, Neelima, Fichorova, Raina N, Dezzutti, Charlene S, Hillier, Sharon L, Archer, David F, Creinin, Mitchell D, Schwartz, Jill L, Callahan, Marianne M, Doncel, Gustavo F

“…Several microbicides, including nonoxynol-9 (N-9) and cellulose sulfate (CS), looked promising during early trials but failed in efficacy trials. We aimed to…”
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Does tenofovir gel or do other microbicide products affect detection of biomarkers of semen exposure in vitro? by Snead, Margaret C, Kourtis, Athena P, Melendez, Johan H, Black, Carolyn M, Mauck, Christine K, Penman-Aguilar, Ana, Chaney, Dorothy M, Gallo, Maria F, Jamieson, Denise J, Macaluso, Maurizio, Doncel, Gustavo F

“…Abstract Objectives There is currently no information on whether products evaluated in HIV microbicide trials affect the detection of the semen biomarkers…”
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Effect of topical vaginal products on the detection of prostate-specific antigen, a biomarker of semen exposure, using ABAcards by Snead, Margaret C, Kourtis, Athena P, Black, Carolyn M, Mauck, Christine K, Brown, Teresa M, Penman-Aguilar, Ana, Melendez, Johan H, Gallo, Maria F, Jamieson, Denise J, Macaluso, Maurizio

“…Abstract Background Prostate-specific antigen (PSA) is a biomarker of recent semen exposure. There is currently only limited information on whether topical…”
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SILCS diaphragm: postcoital testing of a new single-size contraceptive device by Schwartz, Jill L, Ballagh, Susan A, Creinin, Mitchell D, Rountree, Robert W, Kilbourne-Brook, Maggie, Mauck, Christine K, Callahan, Marianne M

“…Abstract Background This study was conducted to compare the effectiveness of a new, single-size silicone contraceptive diaphragm used with either spermicide…”
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Colposcopy: Still Useful in Microbicide Safety Trials? by Mauck, Christine K., Weiner, Debra H., Lai, Jaim Jou, Schwartz, Jill L.

“…Background: Colposcopy is used to evaluate vaginal microbicides, but its link to risk of HIV is unknown. This reanalysis of 9 safety studies determined the…”
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