Search Results - "Maubach, Karen A."

The role of prostaglandins in the bradykinin-induced activation of serosal afferents of the rat jejunum in vitro by Maubach, Karen A., Grundy, David

“…This study was performed to elucidate the role of prostaglandins in the action of bradykinin on serosal afferent neurones supplying the rat jejunum…”
Get full text

Substance P stimulates inhibitory synaptic transmission in the guinea pig basolateral amygdala in vitro by Maubach, Karen A, Martin, Karine, Smith, David W, Hewson, Louise, Frankshun, Robert A, Harrison, Timothy, Seabrook, Guy R

“…To determine the physiological role of tachykinin NK1 receptors in the basolateral nucleus of the amygdala (BLN) we have studied the electrophysiological…”
Get full text

Identification of a Novel, Selective GABAA α5 Receptor Inverse Agonist Which Enhances Cognition by Chambers, Mark S, Atack, John R, Broughton, Howard B, Collinson, Neil, Cook, Susan, Dawson, Gerard R, Hobbs, Sarah C, Marshall, George, Maubach, Karen A, Pillai, Goplan V, Reeve, Austin J, MacLeod, Angus M

“…In pursuit of a GABAA α5-subtype-selective inverse agonist to enhance cognition, a series of 6,7-dihydro-2-benzothiophen-4(5H)-ones has been identified as a…”
Get full text

6,7-Dihydro-2-benzothiophen-4(5H)-ones:  A Novel Class of GABA-A α5 Receptor Inverse Agonists by Chambers, Mark S, Atack, John R, Bromidge, Frances A, Broughton, Howard B, Cook, Susan, Dawson, Gerard R, Hobbs, Sarah C, Maubach, Karen A, Reeve, Austin J, Seabrook, Guy R, Wafford, Keith, MacLeod, Angus M

“…Nonselective inverse agonists at the benzodiazepine binding site on the GABA-A chloride ion channel enhance cognitive performance in animals but cannot be used…”
Get full text

Triazolam suppresses the induction of hippocampal long-term potentiation by Maubach, Karen A, Martin, Karine, Choudhury, Hedaythul I, Seabrook, Guy R

“…Benzodiazepines are sedative hypnotics that produce marked anterograde amnesia in humans. These pharmacological properties are thought to result from the…”
Get full text

Novel strategies for pharmacotherapy of depression by Maubach, Karen A, Rupniak, Nadia MJ, Kramer, Mark S, Hill, Raymond G

“…Modulating monoamine activity as a therapeutic strategy continues to dominate antidepressant research, with a recent emphasis on agents with multiple targets,…”
Get full text

Electrophysiological characterisation of tachykinin receptors in the rat nucleus of the solitary tract and dorsal motor nucleus of the vagus in vitro by Maubach, Karen A., Jones, Roland S. G.

“…1 Recent studies have shown antagonists at the NK1 subtype of receptor for tachykinins are anti‐emetics and suggested that this may result from blockade of…”
Get full text

Enhanced Learning and Memory and Altered GABAergic Synaptic Transmission in Mice Lacking the α5 Subunit of the GABAAReceptor by Collinson, Neil, Kuenzi, Frederick M., Jarolimek, Wolfgang, Maubach, Karen A., Cothliff, Rosa, Sur, Cyrille, Smith, Alison, Otu, Franklin M., Howell, Owain, Atack, John R., McKernan, Ruth M., Seabrook, Guy R., Dawson, Gerry R., Whiting, Paul J., Rosahl, Thomas W.

“…The α5 subunit of the GABA A receptor is localized mainly to the hippocampus of the mammalian brain. The significance of this rather distinct localization and…”
Get full text

Pharmacology of recombinant human GABA A receptor subtypes measured using a novel pH-based high-throughput functional efficacy assay by Simpson, Peter B, Woollacott, Anthony J, Pillai, Gopalan V, Maubach, Karen A, Hadingham, Karen L, Martin, Karine, Choudhury, Hedaythul I, Seabrook, Guy R

“…To facilitate the discovery of novel compounds that modulate human GABA A receptor function, we have developed a high throughput functional assay using a…”
Get full text

Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition by Chambers, Mark S, Atack, John R, Broughton, Howard B, Collinson, Neil, Cook, Susan, Dawson, Gerard R, Hobbs, Sarah C, Marshall, George, Maubach, Karen A, Pillai, Goplan V, Reeve, Austin J, MacLeod, Angus M

“…In pursuit of a GABA(A) alpha5-subtype-selective inverse agonist to enhance cognition, a series of 6,7-dihydro-2-benzothiophen-4(5H)-ones has been identified…”
Get full text

Identification of a Novel, Selective GABA A α5 Receptor Inverse Agonist Which Enhances Cognition by Chambers, Mark S., Atack, John R., Broughton, Howard B., Collinson, Neil, Cook, Susan, Dawson, Gerard R., Hobbs, Sarah C., Marshall, George, Maubach, Karen A., Pillai, Goplan V., Reeve, Austin J., MacLeod, Angus M.

Get full text

Identification of a novel, selective GABAA a5 receptor inverse agonist which enhances cognition by CHAMBERS, Mark S, ATACK, John R, REEVE, Austin J, MACLEOD, Angus M, BROUGHTON, Howard B, COLLINSON, Neil, COOK, Susan, DAWSON, Gerard R, HOBBS, Sarah C, MARSHALL, George, MAUBACH, Karen A, PILLAI, Goplan V

Get full text

Enhanced Learning and Memory and Altered GABAergic Synaptic Transmission in Mice Lacking the alpha 5 Subunit of the GABAA Receptor by Collinson, Neil, Kuenzi, Frederick M, Jarolimek, Wolfgang, Maubach, Karen A, Cothliff, Rosa, Sur, Cyrille, Smith, Alison, Otu, Franklin M, Howell, Owain, Atack, John R, McKernan, Ruth M, Seabrook, Guy R, Dawson, Gerry R, Whiting, Paul J, Rosahl, Thomas W

“…The alpha5 subunit of the GABA(A) receptor is localized mainly to the hippocampus of the mammalian brain. The significance of this rather distinct localization…”
Get full text

Enhanced Learning and Memory and Altered GABAergic Synaptic Transmission in Mice Lacking the α5 Subunit of the GABA A Receptor by Collinson, Neil, Kuenzi, Frederick M., Jarolimek, Wolfgang, Maubach, Karen A., Cothliff, Rosa, Sur, Cyrille, Smith, Alison, Otu, Franklin M., Howell, Owain, Atack, John R., McKernan, Ruth M., Seabrook, Guy R., Dawson, Gerry R., Whiting, Paul J., Rosahl, Thomas W.

Get full text

In vitro and in vivo properties of 3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA receptor alpha5 subtype-selective inverse agonist by Atack, John R, Maubach, Karen A, Wafford, Keith A, O'Connor, Desmond, Rodrigues, A David, Evans, David C, Tattersall, F David, Chambers, Mark S, MacLeod, Angus M, Eng, Wai-Si, Ryan, Christine, Hostetler, Eric, Sanabria, Sandra M, Gibson, Raymond E, Krause, Stephen, Burns, H Donald, Hargreaves, Richard J, Agrawal, Nancy G B, McKernan, Ruth M, Murphy, M Gail, Gingrich, Kevin, Dawson, Gerard R, Musson, Donald G, Petty, Kevin J

“…3-tert-Butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d][1,2,4]triazine (MRK-016) is a pyrazolotriazine with an…”
Get more information

6,7-Dihydro-2-benzothiophen-4(5H)-ones: a novel class of GABA-A alpha5 receptor inverse agonists by Chambers, Mark S, Atack, John R, Bromidge, Frances A, Broughton, Howard B, Cook, Susan, Dawson, Gerard R, Hobbs, Sarah C, Maubach, Karen A, Reeve, Austin J, Seabrook, Guy R, Wafford, Keith, MacLeod, Angus M

“…Nonselective inverse agonists at the benzodiazepine binding site on the GABA-A chloride ion channel enhance cognitive performance in animals but cannot be used…”
Get full text

Pharmacology of recombinant human GABAA receptor subtypes measured using a novel pH-based high-throughput functional efficacy assay by SIMPSON, P. B, WOOLLACOTT, A. J, PILLAI, G. V, MAUBACH, K. A, HADINGHAM, K. L, MARTIN, K, CHOUDHURY, H. I, SEABROOK, G. R

Get full text