Search Results - "Maubach, KA"

BGC20‐1531, a novel, potent and selective prostanoid EP4 receptor antagonist: a putative new treatment for migraine headache by Maubach, KA, Davis, RJ, Clark, DE, Fenton, G, Lockey, PM, Clark, KL, Oxford, AW, Hagan, RM, Routledge, C, Coleman, RA

“…Background and purpose:  Prostanoid EP4 receptor antagonists may have therapeutic utility in the treatment of migraine since EP4 receptors have been shown to…”
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BGC20‐1531, a novel, potent and selective prostanoid EP 4 receptor antagonist: a putative new treatment for migraine headache by Maubach, KA, Davis, RJ, Clark, DE, Fenton, G, Lockey, PM, Clark, KL, Oxford, AW, Hagan, RM, Routledge, C, Coleman, RA

“…Background and purpose:  Prostanoid EP 4 receptor antagonists may have therapeutic utility in the treatment of migraine since EP 4 receptors have been shown to…”
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The role of prostaglandins in the bradykinin-induced activation of serosal afferents of the rat jejunum in vitro by Maubach, Karen A., Grundy, David

“…This study was performed to elucidate the role of prostaglandins in the action of bradykinin on serosal afferent neurones supplying the rat jejunum…”
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Neurokinin-1 receptors in the rat nucleus tractus solitarius: pre- and postsynaptic modulation of glutamate and GABA release by Bailey, C.P, Maubach, K.A, Jones, R.S.G

“…Neurokinins such as substance P and neurokinin A have long been thought to act as neurotransmitters or modulators in the nucleus tractus solitarius. However,…”
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Chronic substance P (NK 1) receptor antagonist and conventional antidepressant treatment increases burst firing of monoamine neurones in the locus coeruleus by Maubach, K.A, Martin, K, Chicchi, G, Harrison, T, Wheeldon, A, Swain, C.J, Cumberbatch, M.J, Rupniak, N.M.J, Seabrook, G.R

“…The mechanism of action of conventional antidepressants (e.g. imipramine) has been linked to modulation of central monoamine systems. Substance P (NK 1)…”
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BGC20-1531, a novel, potent and selective prostanoid EP receptor antagonist: a putative new treatment for migraine headache by Maubach, K A, Davis, R J, Clark, D E, Fenton, G, Lockey, P M, Clark, K L, Oxford, A W, Hagan, R M, Routledge, C, Coleman, R A

“…Prostanoid EP(4) receptor antagonists may have therapeutic utility in the treatment of migraine since EP(4) receptors have been shown to be involved in…”
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Role of the histidine residue at position 105 in the human alpha 5 containing GABA(A) receptor on the affinity and efficacy of benzodiazepine site ligands by Kelly, M D, Smith, A, Banks, G, Wingrove, P, Whiting, P W, Atack, J, Seabrook, G R, Maubach, K A

“…1. A histidine residue in the N-terminal extracellular region of alpha 1,2,3,5 subunits of the human GABA(A) receptor, which is replaced by an arginine in…”
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Triazolam suppresses the induction of hippocampal long-term potentiation by Maubach, Karen A, Martin, Karine, Choudhury, Hedaythul I, Seabrook, Guy R

“…Benzodiazepines are sedative hypnotics that produce marked anterograde amnesia in humans. These pharmacological properties are thought to result from the…”
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Novel strategies for pharmacotherapy of depression by Maubach, Karen A, Rupniak, Nadia MJ, Kramer, Mark S, Hill, Raymond G

“…Modulating monoamine activity as a therapeutic strategy continues to dominate antidepressant research, with a recent emphasis on agents with multiple targets,…”
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Design and application of a novel brain slice system that permits independent electrophysiological recordings from multiple slices by Stopps, M., Allen, N., Barrett, R., Choudhury, H.I., Jarolimek, W., Johnson, M., Kuenzi, F.M., Maubach, K.A., Nagano, N., Seabrook, G.R.

“…We describe a novel brain slice system ‘SliceMaster’ that allows electrophysiological recordings from eight brain slices independently. The system consists of…”
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Substance P stimulates inhibitory synaptic transmission in the guinea pig basolateral amygdala in vitro by Maubach, Karen A, Martin, Karine, Smith, David W, Hewson, Louise, Frankshun, Robert A, Harrison, Timothy, Seabrook, Guy R

“…To determine the physiological role of tachykinin NK1 receptors in the basolateral nucleus of the amygdala (BLN) we have studied the electrophysiological…”
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Electrophysiological characterisation of tachykinin receptors in the rat nucleus of the solitary tract and dorsal motor nucleus of the vagus in vitro by Maubach, Karen A., Jones, Roland S. G.

“…1 Recent studies have shown antagonists at the NK1 subtype of receptor for tachykinins are anti‐emetics and suggested that this may result from blockade of…”
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Tachykinins may Modify Spontaneous Epileptiform Activity in the Rat Entorhinal Cortex In Vitro by Activating Gabaergic Inhibition by Maubach, K.A., Cody, C., Cody, C.

“…The effects of substance P and related tachykinins on intrinsic membrane properties and synaptic responses of neurons in cortical slices were determined…”
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Enhanced Learning and Memory and Altered GABAergic Synaptic Transmission in Mice Lacking the alpha 5 Subunit of the GABA sub(A) Receptor by Collinson, N, Kuenzi, F M, Jarolimek, W, Maubach, KA, Cothliff, R, Sur, C, Smith, A, Otu, F M, Howell, O, Atack, J R, McKernan, R M, Seabrook, G R, Dawson, G R, Whiting, P J, Rosahl, T W

“…The alpha 5 subunit of the GABA sub(A) receptor is localized mainly to the hippocampus of the mammalian brain. The significance of this rather distinct…”
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The GABA A receptor as a potential target for the treatment of cognitive dysfunction by Maubach, K.A.

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Pharmacology of recombinant human GABA A receptor subtypes measured using a novel pH-based high-throughput functional efficacy assay by Simpson, Peter B, Woollacott, Anthony J, Pillai, Gopalan V, Maubach, Karen A, Hadingham, Karen L, Martin, Karine, Choudhury, Hedaythul I, Seabrook, Guy R

“…To facilitate the discovery of novel compounds that modulate human GABA A receptor function, we have developed a high throughput functional assay using a…”
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