Search Results - "Matzuk, Martin M"

The biology of infertility: research advances and clinical challenges by Lamb, Dolores J, Matzuk, Martin M

“…Reproduction is required for the survival of all mammalian species, and thousands of essential 'sex' genes are conserved through evolution. Basic research…”
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The Mammalian Ovary from Genesis to Revelation by Edson, Mark A, Nagaraja, Ankur K, Matzuk, Martin M

“…Two major functions of the mammalian ovary are the production of germ cells (oocytes), which allow continuation of the species, and the generation of bioactive…”
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Small-Molecule Inhibition of BRDT for Male Contraception by Matzuk, Martin M., McKeown, Michael R., Filippakopoulos, Panagis, Li, Qinglei, Ma, Lang, Agno, Julio E., Lemieux, Madeleine E., Picaud, Sarah, Yu, Richard N., Qi, Jun, Knapp, Stefan, Bradner, James E.

“…A pharmacologic approach to male contraception remains a longstanding challenge in medicine. Toward this objective, we explored the spermatogenic effects of a…”
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Lineage specification of ovarian theca cells requires multicellular interactions via oocyte and granulosa cells by Liu, Chang, Peng, Jia, Matzuk, Martin M., Yao, Humphrey H.-C.

“…Organogenesis of the ovary is a highly orchestrated process involving multiple lineage determination of ovarian surface epithelium, granulosa cells and theca…”
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ARMC12 regulates spatiotemporal mitochondrial dynamics during spermiogenesis and is required for male fertility by Shimada, Keisuke, Park, Soojin, Miyata, Haruhiko, Yu, Zhifeng, Morohoshi, Akane, Oura, Seiya, Matzuk, Martin M., Ikawa, Masahito

“…The mammalian sperm midpiece has a unique double-helical structure called the mitochondrial sheath that wraps tightly around the axoneme. Despite the…”
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Activin-like kinase 5 (ALK5) inactivation in the mouse uterus results in metastatic endometrial carcinoma by Monsivais, Diana, Peng, Jia, Kang, Yibin, Matzuk, Martin M.

“…The endometrial lining of the uterine cavity is a highly dynamic tissue that is under the continuous control of the ovarian steroid hormones, estrogen and…”
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NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility by Kiyozumi, Daiji, Noda, Taichi, Yamaguchi, Ryo, Tobita, Tomohiro, Matsumura, Takafumi, Shimada, Kentaro, Kodani, Mayo, Kohda, Takashi, Fujihara, Yoshitaka, Ozawa, Manabu, Yu, Zhifeng, Miklossy, Gabriella, Bohren, Kurt M, Horie, Masato, Okabe, Masaru, Matzuk, Martin M, Ikawa, Masahito

“…The lumicrine system is a postulated signaling system in which testis-derived (upstream) secreted factors enter the male reproductive tract to regulate…”
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Growth differentiation factor 9:bone morphogenetic protein 15 heterodimers are potent regulators of ovarian functions by Peng, Jia, Li, Qinglei, Wigglesworth, Karen, Rangarajan, Adithya, Kattamuri, Chandramohan, Peterson, Randall T, Eppig, John J, Thompson, Thomas B, Matzuk, Martin M

“…The TGF-β superfamily is the largest family of secreted proteins in mammals, and members of the TGF-β family are involved in most developmental and…”
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High-grade serous ovarian cancer arises from fallopian tube in a mouse model by Kim, Jaeyeon, Coffey, Donna M, Creighton, Chad J, Yu, Zhifeng, Hawkins, Shannon M, Matzuk, Martin M

“…Although ovarian cancer is the most lethal gynecologic malignancy in women, little is known about how the cancer initiates and metastasizes. In the last…”
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In vitro differentiation of human embryonic stem cells into ovarian follicle-like cells by Jung, Dajung, Xiong, Jie, Ye, Min, Qin, Xunsi, Li, Lin, Cheng, Shunfeng, Luo, Mengyuan, Peng, Jia, Dong, Ji, Tang, Fuchou, Shen, Wei, Matzuk, Martin M., Kee, Kehkooi

“…Understanding the unique mechanisms of human oogenesis necessitates the development of an in vitro system of stem cell differentiation into oocytes…”
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Follistatin is critical for mouse uterine receptivity and decidualization by Fullerton, Paul T., Monsivais, Diana, Kommagani, Ramakrishna, Matzuk, Martin M.

“…Embryo implantation remains a significant challenge for assisted reproductive technology, with implantation failure occurring in ∼50% of in vitro fertilization…”
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Proximity-dependent biotin labeling in testicular germ cells identified TESMIN-associated proteins by Oura, Seiya, Ninomiya, Akinori, Sugihara, Fuminori, Matzuk, Martin M., Ikawa, Masahito

“…Characterization of protein–protein interactions (PPI) is a key to understanding the functions of proteins of interest. Recently developed proximity-dependent…”
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Bidirectional communication between oocytes and ovarian follicular somatic cells is required for meiotic arrest of mammalian oocytes by Wigglesworth, Karen, Lee, Kyung-Bon, O’Brien, Marilyn J., Peng, Jia, Matzuk, Martin M., Eppig, John J.

“…Coordinated regulation of oocyte and ovarian follicular development is essential for fertility. In particular, the progression of meiosis, a germ cell-specific…”
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TSKS localizes to nuage in spermatids and regulates cytoplasmic elimination during spermiation by Shimada, Keisuke, Park, Soojin, Oura, Seiya, Noda, Taichi, Morohoshi, Akane, Matzuk, Martin M, Ikawa, Masahito

“…Spermatozoa have a streamlined shape to swim through the oviduct to fertilize oocytes. To become svelte spermatozoa, spermatid cytoplasm must be eliminated in…”
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MRG15 is required for pre-mRNA splicing and spermatogenesis by Iwamori, Naoki, Tominaga, Kaoru, Sato, Tetsuya, Riehle, Kevin, Iwamori, Tokuko, Ohkawa, Yasuyuki, Coarfa, Cristian, Ono, Etsuro, Matzuk, Martin M.

“…Splicing can be epigenetically regulated and involved in cellular differentiation in somatic cells, but the interplay of epigenetic factors and the splicing…”
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MLL2 is required in oocytes for bulk histone 3 lysine 4 trimethylation and transcriptional silencing by Andreu-Vieyra, Claudia V, Chen, Ruihong, Agno, Julio E, Glaser, Stefan, Anastassiadis, Konstantinos, Stewart, A Francis, Matzuk, Martin M

“…During gametogenesis and pre-implantation development, the mammalian epigenome is reprogrammed to establish pluripotency in the epiblast. Here we show that the…”
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Tmprss12 is required for sperm motility and uterotubal junction migration in mice by Larasati, Tamara, Noda, Taichi, Fujihara, Yoshitaka, Shimada, Keisuke, Tobita, Tomohiro, Yu, Zhifeng, Matzuk, Martin M, Ikawa, Masahito

“…Spermatozoa are produced in the testis but gain their fertilizing ability during epididymal migration. This necessary step in sperm maturation includes…”
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A small secreted protein NICOL regulates lumicrine-mediated sperm maturation and male fertility by Kiyozumi, Daiji, Shimada, Kentaro, Chalick, Michael, Emori, Chihiro, Kodani, Mayo, Oura, Seiya, Noda, Taichi, Endo, Tsutomu, Matzuk, Martin M., Wreschner, Daniel H., Ikawa, Masahito

“…The mammalian spermatozoa produced in the testis require functional maturation in the epididymis for their full competence. Epididymal sperm maturation is…”
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Oocyte-specific Wee1-like protein kinase 2 is dispensable for fertility in mice by Nozawa, Kaori, Liao, Zian, Satouh, Yuhkoh, Geng, Ting, Ikawa, Masahito, Monsivais, Diana, Matzuk, Martin M

“…Wee1-like protein kinase 2 (WEE2) is an oocyte-specific protein tyrosine kinase involved in the regulation of oocyte meiotic arrest in humans. As such, it has…”
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CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice by Lu, Yonggang, Oura, Seiya, Matsumura, Takafumi, Oji, Asami, Sakurai, Nobuyuki, Fujihara, Yoshitaka, Shimada, Keisuke, Miyata, Haruhiko, Tobita, Tomohiro, Noda, Taichi, Castaneda, Julio M, Kiyozumi, Daiji, Zhang, Qian, Larasati, Tamara, Young, Samantha A.M, Kodani, Mayo, Huddleston, Caitlin A, Robertson, Matthew J, Coarfa, Cristian, Isotani, Ayako, Aitken, R. John, Okabe, Masaru, Matzuk, Martin M, Garcia, Thomas X, Ikawa, Masahito

“…More than 1000 genes are predicted to be predominantly expressed in mouse testis, yet many of them remain unstudied in terms of their roles in spermatogenesis…”
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