Predictors of microsurgical varicocelectomy efficacy in male infertility treatment: critical assessment and systematization

Predictors of microsurgical varicocelectomy efficacy in male infertility treatment: critical assessment and systematization

In this review, we tried to systematize all the evidence (from PubMed [MEDLINE], Scopus, Cochrane Library, EBSCO, Embase, and Google Scholar) from 1993 to 2021 on the predictors of microsurgical varicocelectomy efficacy in male infertility treatment. Regarding the outcomes of varicocele repair, we c...

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Bibliographic Details
Published in:Asian journal of andrology Vol. 25; no. 1; pp. 21 - 28
Main Authors: Shomarufov, Azizbek, Bozhedomov, Vladimir, Sorokin, Nikolay, Matyukhov, Igor, Fozilov, Abdukodir, Abbosov, Shukhrat, Kamalov, Armais
Format: Journal Article
Language:English
Published: China Wolters Kluwer India Pvt. Ltd 01-01-2023
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt. Ltd
Wolters Kluwer - Medknow
Wolters Kluwer Medknow Publications
Subjects:
Analysis
Evidence-based medicine
Female
Humans
Infertility
Infertility, Male
Infertility, Male - etiology
Infertility, Male - surgery
Male
male infertility; microsurgical varicocelectomy; predictor; pregnancy; semen; varicocele
Microsurgery
Pregnancy
Review
Semen
Sperm
Sperm Count
Sperm Motility
Varicocele
Varicocele - complications
Varicocele - surgery
semen
predictor
microsurgical varicocelectomy
male infertility
pregnancy
varicocele
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Summary:In this review, we tried to systematize all the evidence (from PubMed [MEDLINE], Scopus, Cochrane Library, EBSCO, Embase, and Google Scholar) from 1993 to 2021 on the predictors of microsurgical varicocelectomy efficacy in male infertility treatment. Regarding the outcomes of varicocele repair, we considered semen improvement and pregnancy and analyzed them separately. Based on the 2011 Oxford CEBM Levels of Evidence, we assigned a score to each trial that studied the role of the predictor. We systematized the studied predictors based on the total points, which were, in turn, calculated based on the number and quality of studies that confirmed or rejected the studied predictor as significant, into three levels of significance: predictors of high, moderate, and low clinical significance. Preoperative total motile sperm count (TMSC) coupled with sperm concentration can be a significant predictor of semen improvement and pregnancy after varicocelectomy. In addition, for semen improvement alone, scrotal Doppler ultrasound (DUS) parameters, sperm DNA fragmentation index (DFI), and bilateral varicocelectomy are reliable predictors of microsurgical varicocelectomy efficacy.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ObjectType-Undefined-4
ISSN:1008-682X
1745-7262
1745-7262
1008-682X
DOI:10.4103/aja2021125