Search Results - "Matveyenko, Aleksey V"

Bmal1 is required for beta cell compensatory expansion, survival and metabolic adaptation to diet-induced obesity in mice by Rakshit, Kuntol, Hsu, Tu Wen, Matveyenko, Aleksey V.

“…Aims/hypothesis Obesity and consequent insulin resistance are known risk factors for type 2 diabetes. A compensatory increase in beta cell function and mass in…”
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Consequences of Exposure to Light at Night on the Pancreatic Islet Circadian Clock and Function in Rats by JINGYI QIAN, BLOCK, Gene D, COLWELL, Christopher S, MATVEYENKO, Aleksey V

“…There is a correlation between circadian disruption, type 2 diabetes mellitus (T2DM), and islet failure. However, the mechanisms underlying this association…”
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Heterogeneous enhancer states orchestrate β cell responses to metabolic stress by Wang, Liu, Wu, Jie, Sramek, Madeline, Obayomi, S. M. Bukola, Gao, Peidong, Li, Yan, Matveyenko, Aleksey V., Wei, Zong

“…Obesity-induced β cell dysfunction contributes to the onset of type 2 diabetes. Nevertheless, elucidating epigenetic mechanisms underlying islet dysfunction at…”
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Pro-inflammatory β cell small extracellular vesicles induce β cell failure through activation of the CXCL10/CXCR3 axis in diabetes by Javeed, Naureen, Her, Tracy K., Brown, Matthew R., Vanderboom, Patrick, Rakshit, Kuntol, Egan, Aoife M., Vella, Adrian, Lanza, Ian, Matveyenko, Aleksey V.

“…Coordinated communication among pancreatic islet cells is necessary for maintenance of glucose homeostasis. In diabetes, chronic exposure to pro-inflammatory…”
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A method for the generation of human stem cell-derived alpha cells by Peterson, Quinn P., Veres, Adrian, Chen, Lihua, Slama, Michael Q., Kenty, Jennifer H. R., Hassoun, Shaimaa, Brown, Matthew R., Dou, Haiqiang, Duffy, Caden D., Zhou, Quan, Matveyenko, Aleksey V., Tyrberg, Björn, Sörhede-Winzell, Maria, Rorsman, Patrik, Melton, Douglas A.

“…The generation of pancreatic cell types from renewable cell sources holds promise for cell replacement therapies for diabetes. Although most effort has focused…”
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It's What and When You Eat: An Overview of Transcriptional and Epigenetic Responses to Dietary Perturbations in Pancreatic Islets by Brown, Matthew R, Matveyenko, Aleksey V

“…Our ever-changing modern environment is a significant contributor to the increased prevalence of many chronic diseases, and particularly, type 2 diabetes…”
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Disruption of Circadian Rhythms Accelerates Development of Diabetes through Pancreatic Beta-Cell Loss and Dysfunction by Gale, John E., Cox, Heather I., Qian, Jingyi, Block, Gene D., Colwell, Christopher S., Matveyenko, Aleksey V.

“…Type 2 diabetes mellitus (T2DM) is complex metabolic disease that arises as a consequence of interactions between genetic predisposition and environmental…”
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Pulsatile Portal Vein Insulin Delivery Enhances Hepatic Insulin Action and Signaling by MATVEYENKO, Aleksey V, LIUWANTARA, David, BUTLER, Peter C, GURLO, Tatyana, KIRAKOSSIAN, David, DALLA MAN, Chiara, COBELLI, Claudio, WHITE, Morris F, COPPS, Kyle D, VOLPI, Elena, FUJITA, Satoshi

“…Insulin is secreted as discrete insulin secretory bursts at ~5-min intervals into the hepatic portal vein, these pulses being attenuated early in the…”
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Transcription Factor 7-Like 2 Regulates β-Cell Survival and Function in Human Pancreatic Islets by LUAN SHU, SAUTER, Nadine S, SCHULTHESS, Fabienne T, MATVEYENKO, Aleksey V, OBERHOLZER, José, MAEDLER, Kathrin

“…Transcription Factor 7-Like 2 Regulates β-Cell Survival and Function in Human Pancreatic Islets Luan Shu 1 , Nadine S. Sauter 1 , Fabienne T. Schulthess 1 ,…”
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β-Cell Deficit Due to Increased Apoptosis in the Human Islet Amyloid Polypeptide Transgenic (HIP) Rat Recapitulates the Metabolic Defects Present in Type 2 Diabetes by Matveyenko, Aleksey V, Butler, Peter C

“…β-Cell Deficit Due to Increased Apoptosis in the Human Islet Amyloid Polypeptide Transgenic (HIP) Rat Recapitulates the Metabolic Defects Present in Type 2…”
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Inhibition of TBK1/IKKε Promotes Regeneration of Pancreatic β-cells by Xu, Jin, Jia, Yun-Fang, Tapadar, Subhasish, Weaver, Jessica D., Raji, Idris O., Pithadia, Deeti J., Javeed, Naureen, García, Andrés J., Choi, Doo-Sup, Matveyenko, Aleksey V., Oyelere, Adegboyega K., Shin, Chong Hyun

“…β-cell proliferation induction is a promising therapeutic strategy to restore β-cell mass. By screening small molecules in a transgenic zebrafish model of type…”
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The nuclear receptor REV-ERBα is implicated in the alteration of β-cell autophagy and survival under diabetogenic conditions by Brown, Matthew R., Laouteouet, Damien, Delobel, Morgane, Villard, Orianne, Broca, Christophe, Bertrand, Gyslaine, Wojtusciszyn, Anne, Dalle, Stéphane, Ravier, Magalie A., Matveyenko, Aleksey V., Costes, Safia

“…Pancreatic β-cell failure in type 2 diabetes mellitus (T2DM) is associated with impaired regulation of autophagy which controls β-cell development, function,…”
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Timing is everything: implications for metabolic consequences of sleep restriction by Colwell, Christopher S, Matveyenko, Aleksey V

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Circadian Etiology of Type 2 Diabetes Mellitus by Javeed, Naureen, Matveyenko, Aleksey V

“…The epidemic of Type 2 diabetes mellitus necessitates development of novel therapeutic and preventative strategies to attenuate expansion of this debilitating…”
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Induction of Core Circadian Clock Transcription Factor Bmal1 Enhances β-Cell Function and Protects Against Obesity-Induced Glucose Intolerance by Rakshit, Kuntol, Matveyenko, Aleksey V

“…Type 2 diabetes mellitus (T2DM) is characterized by β-cell dysfunction as a result of impaired glucose-stimulated insulin secretion (GSIS). Studies show that…”
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Live-cell imaging of glucose-induced metabolic coupling of β and α cell metabolism in health and type 2 diabetes by Wang, Zhongying, Gurlo, Tatyana, Matveyenko, Aleksey V., Elashoff, David, Wang, Peiyu, Rosenberger, Madeline, Junge, Jason A., Stevens, Raymond C., White, Kate L., Fraser, Scott E., Butler, Peter C.

“…Type 2 diabetes is characterized by β and α cell dysfunction. We used phasor-FLIM (Fluorescence Lifetime Imaging Microscopy) to monitor oxidative…”
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Impaired β-cell glucokinase as an underlying mechanism in diet-induced diabetes by Lu, Brian, Kurmi, Kiran, Munoz-Gomez, Miguel, Jacobus Ambuludi, Egon J, Tonne, Jason M, Rakshit, Kuntol, Hitosugi, Taro, Kudva, Yogish C, Matveyenko, Aleksey V, Ikeda, Yasuhiro

“…High-fat diet (HFD)-fed mouse models have been widely used to study early type 2 diabetes. Decreased β-cell glucokinase (GCK) expression has been observed in…”
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Glucose Intolerance and Lipid Metabolic Adaptations in Response to Intrauterine and Postnatal Calorie Restriction in Male Adult Rats by Garg, Meena, Thamotharan, Manikkavasagar, Dai, Yun, Lagishetty, Venu, Matveyenko, Aleksey V, Lee, W. N. Paul, Devaskar, Sherin U

“…Enhanced de novo lipogenesis (DNL), an adult hepatic adaption, is seen with high carbohydrate or low-fat diets. We hypothesized that ad libitum intake after…”
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Pancreatitis, Pancreatic, and Thyroid Cancer With Glucagon-Like Peptide-1–Based Therapies by Elashoff, Michael, Matveyenko, Aleksey V, Gier, Belinda, Elashoff, Robert, Butler, Peter C

“…Background & Aims Glucagon-like peptide-1−based therapy is gaining widespread use for type 2 diabetes, although there are concerns about risks for pancreatitis…”
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Mechanisms of Impaired Fasting Glucose and Glucose Intolerance Induced by a ∼50% Pancreatectomy by MATVEYENKO, Aleksey V, VELDHUIS, Johannes D, BUTLER, Peter C

“…Mechanisms of Impaired Fasting Glucose and Glucose Intolerance Induced by a ∼50% Pancreatectomy Aleksey V. Matveyenko 1 , Johannes D. Veldhuis 2 and Peter C…”
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