Search Results - "Matuszewski, B. K."

Standard line slopes as a measure of a relative matrix effect in quantitative HPLC–MS bioanalysis by Matuszewski, B.K.

“…A simple experimental approach for studying and identifying the relative matrix effect (for example “plasma-to-plasma” and/or “urine-to-urine”) in quantitative…”
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Strategies for the Assessment of Matrix Effect in Quantitative Bioanalytical Methods Based on HPLC−MS/MS by Matuszewski, B. K, Constanzer, M. L, Chavez-Eng, C. M

“…In recent years, high-performance liquid chromatography (HPLC) with tandem mass spectrometric (MS/MS) detection has been demonstrated to be a powerful…”
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Matrix Effect in Quantitative LC/MS/MS Analyses of Biological Fluids:  A Method for Determination of Finasteride in Human Plasma at Picogram Per Milliliter Concentrations by Matuszewski, B. K, Constanzer, M. L, Chavez-Eng, C. M

“…Contrary to common perceptions, the reliability of quantitative assays for the determination of drugs in biological fluids using high-performance liquid…”
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Determination of the HIV integrase inhibitor, MK-0518 (raltegravir), in human plasma using 96-well liquid–liquid extraction and HPLC-MS/MS by Merschman, S.A., Vallano, P.T., Wenning, L.A., Matuszewski, B.K., Woolf, E.J.

“…An HPLC-MS/MS method was developed for the determination of MK-0518 (raltegravir), an HIV integrase inhibitor, in human plasma over the concentration range of…”
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Effect of the sample matrix on the determination of indinavir in human urine by HPLC with turbo ion spray tandem mass spectrometric detection by Fu, I, Woolf, E.J, Matuszewski, B.K

“…The HPLC/tandem mass spectrometric (LC/MS/MS) behavior of indinavir, an HIV protease inhibitor, in human urine is presented as an example of a case where…”
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Elimination and Biochemical Responses to Intravenous Alendronate in Postmenopausal Osteoporosis by Khan, Sohail A., Kanis, John A., Vasikaran, Samuel, Kline, W. F., Matuszewski, B. K., McCloskey, Eugene V., Beneton, Monique N. C., Gertz, Barry J., Sciberras, David G., Holland, S. D., Orgee, Jane, Coombes, Gillian M., Rogers, Suzanne R., Porras, A. G.

“…Postmenopausal women with established vertebral osteoporosis were studied for 2 years to determine the terminal elimination half‐life and the duration of…”
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Comparison of solid-phase microextraction and liquid–liquid extraction in 96-well format for the determination of a drug compound in human plasma by liquid chromatography with tandem mass spectrometric detection by Xie, W., Pawliszyn, J., Mullett, W.M., Matuszewski, B.K.

“…Two sensitive and selective methods based on solid phase microextraction (SPME) and liquid–liquid extraction (LLE) in 96-well format, in combination with high…”
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Determination of fexofenadine in human plasma using 96-well solid phase extraction and HPLC with tandem mass spectrometric detection by Fu, I., Woolf, E.J., Matuszewski, B.K.

“…A fast and sensitive HPLC–MS/MS method, utilizing atmospheric pressure chemical ionization, for the determination of fexofenadine in human plasma is described…”
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Determination of risedronate in human urine by column-switching ion-pair high-performance liquid chromatography with ultraviolet detection by Vallano, P.T, Shugarts, S.B, Kline, W.F, Woolf, E.J, Matuszewski, B.K

“…An HPLC assay for the determination of risedronate in human urine was developed and validated. Risedronate and the internal standard were isolated from 5-ml…”
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Simultaneous determination of Aprepitant and two metabolites in human plasma by high-performance liquid chromatography with tandem mass spectrometric detection by Chavez-Eng, C.M., Constanzer, M.L., Matuszewski, B.K.

“…A method for the simultaneous determination of Aprepitant, I (5-[[2( R)-[1( R)-(3,5-bistrifluoromethylphenyl)ethoxy]-3( S)-(4-fluorophenyl)…”
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Determination of dextromethorphan and its metabolite dextrorphan in human urine using high performance liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry: a study of selectivity of a tandem mass spectrometric assay by Constanzer, M.L., Chavez-Eng, C.M., Fu, I., Woolf, E.J., Matuszewski, B.K.

“…Analytical method for the simultaneous determination of dextromethorphan ( 1) and dextrorphan ( 2) in urine, based on solid-phase extraction of drug from…”
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Determination of a novel substance P inhibitor in human plasma by high-performance liquid chromatography with atmospheric pressure chemical ionization mass spectrometric detection using single and triple quadrupole detectors by Constanzer, M.L, Chavez-Eng, C.M, Dru, J, Kline, W.F, Matuszewski, B.K

“…Methods based on high-performance liquid chromatography (HPLC) with atmospheric-pressure chemical ionization (APCI) mass spectrometric (MS) detection using…”
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Elimination of autosampler carryover in a bioanalytical HPLC-MS/MS method: a case study by Vallano, P.T., Shugarts, S.B., Woolf, E.J., Matuszewski, B.K.

“…A case study in identifying and eliminating the source of autosampler carryover in a bioanalytical HPLC-MS/MS assay is described. Through a series of…”
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Improved procedure for the the determination of rofecoxib in human plasma involving 96-well solid-phase extraction and fluorescence detection by Matthews, C.Z, Woolf, E.J, Matuszewski, B.K

“…An improved assay for the determination of rofecoxib in human plasma samples is described. The analyte and an internal standard were extracted from the plasma…”
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Simultaneous determination of unlabeled and carbon-13-labeled etoricoxib, a new cyclooxygenase-2 inhibitor, in human plasma using HPLC-MS/MS by Rose, M J, Agrawal, N, Woolf, E J, Matuszewski, B K

“…A method for the simultaneous determination of etoricoxib and its carbon-13 analog ((13)C(6)-etoricoxib) from human plasma has been developed and used to…”
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Determination of an investigational HIV integrase inhibitor in human plasma using high performance liquid chromatography with tandem mass spectrometric detection by VALLANO, P. T, WOOLF, E. J, MATUSZEWSKI, B. K

“…An HPLC-MS/MS assay for the determination of an HIV integrase inhibitor,…”
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Simultaneous determination of omeprazole and 5′-hydroxyomeprazole in human plasma by liquid chromatography–tandem mass spectrometry by Woolf, E.J, Matuszewski, B.K

“…A method for the simultaneous determination of omeprazole and 5′-hydroxyomeprazole in human plasma is described. Isolation of the analytes from plasma was…”
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Determination of efavirenz, a selective non-nucleoside reverse transcriptase inhibitor, in human plasma using HPLC with post-column photochemical derivatization and fluorescence detection by Matthews, C.Z., Woolf, E.J., Mazenko, R.S., Haddix-Wiener, H., Chavez-Eng, C.M., Constanzer, M.L., Doss, G.A., Matuszewski, B.K.

“…Methods for the quantitative determination of efavirenz in human plasma and the qualitative assessment of the stereochemical integrity of efavirenz in…”
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High-performance liquid chromatographic–tandem mass spectrometric evaluation and determination of stable isotope labeled analogs of rofecoxib in human plasma samples from oral bioavailability studies by Chavez-Eng, C.M, Constanzer, M.L, Matuszewski, B.K

“…A method for the simultaneous determination of a cyclooxygenase-2 inhibitor, 4-(4-methanesulfonylphenyl)-3-phenyl-5H-furan-2-one (rofecoxib, I) and [ 13C…”
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Studies of the oral bioavailability of alendronate by Gertz, B J, Holland, S D, Kline, W F, Matuszewski, B K, Freeman, A, Quan, H, Lasseter, K C, Mucklow, J C, Porras, A G

“…Clinical studies were performed to examine the oral bioavailability of alendronate (4-amino-1-hydroxy-butylidene-1,1-bisphosphonate monosodium). All studies,…”
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