Search Results - "Matusevicius, Darius"

Defining Satisfactory Methods of Treatment in Rare Diseases When Evaluating Significant Benefit–The EU Regulator's Perspective by Sheean, Maria E., Naumann-Winter, Frauke, Capovilla, Giuseppe, Kalland, Maria Elisabeth, Malikova, Eva, Mariz, Segundo, Matusevicius, Darius, Nistico, Robert, Schwarzer-Daum, Brigitte, Tsigkos, Stelios, Tzogani, Kyriaki, Larsson, Kristina, Magrelli, Armando, Stoyanova-Beninska, Violeta

“…Since the implementation of the EU Orphan Regulation in 2000, the Committee for Orphan Medicinal Products at the European Medicines Agency has been evaluating…”
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Advancing rare disease treatment: EMA’s decade-long insights into engineered adoptive cell therapy for rare cancers and orphan designation by Kalland, Maria Elisabeth, Pose-Boirazian, Tomas, Palomo, Gloria Maria, Naumann-Winter, Frauke, Costa, Enrico, Matusevicius, Darius, Duarte, Dinah M., Malikova, Eva, Vitezic, Dinko, Larsson, Kristina, Magrelli, Armando, Stoyanova-Beninska, Violeta, Mariz, Segundo

“…Adoptive cell therapy (ACT), particularly chimeric antigen receptor (CAR)-T cell therapy, has emerged as a promising approach for targeting and treating rare…”
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Multiple sclerosis: Identification and clinical evaluation of novel CSF biomarkers by Ottervald, Jan, Franzén, Bo, Nilsson, Kerstin, Andersson, Lars I., Khademi, Mohsen, Eriksson, Bodil, Kjellström, Sven, Marko-Varga, György, Végvári, Ákos, Harris, Robert A., Laurell, Thomas, Miliotis, Tasso, Matusevicius, Darius, Salter, Hugh, Ferm, Mats, Olsson, Tomas

“…Multiple sclerosis (MS) is a neuro-inflammatory and neurodegenerative disease that results in damage to myelin sheaths and axons in the central nervous system…”
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Ischemic stroke is associated with a systemic increase of blood mononuclear cells expressing interleukin-8 mRNA by KOSTULAS, N, KIVISÄKK, P, YUMIN HUANG, MATUSEVICIUS, D, KOSTULAS, V, LINK, H

“…Ischemic brain injury secondary to an arterial occlusion is characterized by acute local inflammation. Blood polymorphonuclear leukocytes (PMNL), primarily…”
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Monocyte-derived IL12, CD86 (B7-2) and CD40L expression in relapsing and progressive multiple sclerosis by Filion, Lionel G, Matusevicius, Darius, Graziani-Bowering, Gina M, Kumar, Ashok, Freedman, Mark S

“…Multiple sclerosis has been postulated to be an autoimmune disease in which Th1 immune responses predominate. This response is associated with an increased…”
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High levels of IL-10 secreting cells are present in blood in cerebrovascular diseases by Pelidou, Sigliti-Henrietta, Kostulas, Nikolaos, Matusevicius, Darius, Kivisäkk, Pia, Kostulas, Vasilios, Link, Hans

“…Ischemic stroke is associated with altered systemic immune responses both early after the onset and in the recovery phase. Interleukin (IL)‐10, a Th2 related…”
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γ/δ T Cells in Multiple Sclerosis: Chemokine and Chemokine Receptor Expression by Murzenok, Piotr P., Matusevicius, Darius, Freedman, Mark S.

“…γ/δ T cells are enriched in multiple sclerosis (MS) brain lesions and have been postulated to contribute to the pathogenesis of the disease. Increased…”
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Metalloproteinases and their Tissue Inhibitors in Multiple Sclerosis by Özenci, Volkan, Rinaldi, Luciano, Teleshova, Natalia, Matusevicius, Darius, Kivisäkk, Pia, Kouwenhoven, Mathilde, Link, Hans

“…Matrix metalloproteinases (MMPs) comprise a family of proteolytic enzymes. MMPs are capable of disrupting the blood-brain barrier (BBB), mediating the…”
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Differential requirements for CD28 and CD40 ligand in the induction of experimental autoimmune myasthenia gravis by Shi, Fu‐Dong, He, Bing, Li, Hulun, Matusevicius, Darius, Link, Hans, Ljunggren, Hans‐Gustaf

“…The interactions of CD28‐B7 and CD40‐CD40 ligand (CD40L) pathways in T cell co‐stimulation and autoimmune disease are incompletely understood. We sought to…”
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Tumor necrosis factor-α, lymphotoxin, interleukin (IL)-6, IL-10, IL-12 and perforin mRNA expression in mononuclear cells in response to acetylcholine receptor is augmented in myasthenia gravis by Matusevicius, Darius, Navikas, Vaidrius, Palasik, Witold, Pirskanen, Ritva, Fredrikson, Sten, Link, Hans

“…Myasthenia gravis (MG) is a neuromuscular disorder mediated by autoantibodies against the nicotinic acetylcholine receptor (AChR) on the postsynaptic membrane…”
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Altered expression of costimulatory molecules in myasthenia gravis by Teleshova, Natalia, Matusevicius, Darius, Kivisäkk, Pia, Mustafa, Maha, Pirskanen, Ritva, Link, Hans

“…To characterize the involvement of costimulatory pathways in the pathogenesis of myasthenia gravis (MG), a multiparameter flow cytometry assay was adopted to…”
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The phosphodiesterase i.v. inhibitor rolipram in vitro reduces the numbers of MBP-reactive IFN-gamma and TNF-alpha mRNA expressing blood mononuclear cells in patients with multiple sclerosis by Navikas, V, Matusevicius, D, Söderström, M, Pirskanen, R, Fredrikson, S, Link, H

“…The inflammatory nature of multiple sclerosis (MS) implicates the participation of cytokines as immune response mediators. Targeting the cytokine balance by…”
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No evidence for elevated numbers of mononuclear cells expressing MCP-1 and RANTES mRNA in blood and CSF in multiple sclerosis by Kivisäkk, Pia, Teleshova, Natalia, Özenci, Volkan, Huang, Yumin, Matusevicius, Darius, Fredrikson, Sten, Söderström, Mats, Link, Hans

“…The perivascular accumulation of mononuclear cells (MNC) in brain white matter is critical in the development of active lesions in multiple sclerosis (MS)…”
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